Wolf-Maier K, Cooper RS, Banegas JR, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363–9. https://doi.org/10.1001/jama.289.18.2363.
Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension. 2005;46:454–62. https://doi.org/10.1161/01.HYP.0000177474.06749.98.
Article CAS PubMed Google Scholar
Benjamin EJ, Virani SS, Callaway CW, et al. Heart disease and stroke statistics-2018 update: a report from the American Heart Association. Circulation. 2018;137:e67–492. https://doi.org/10.1161/CIR.0000000000000558.
Hata T, Soga J, Hidaka T, et al. Calcium channel blocker and Rho-associated kinase activity in patients with hypertension. J Hypertens. 2011;29:373–9. https://doi.org/10.1097/HJH.0b013e328340902d.
Article CAS PubMed PubMed Central Google Scholar
Soga J, Noma K, Hata T, et al. Rho-associated kinase activity, endothelial function, and cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2011;31:2353–9. https://doi.org/10.1161/ATVBAHA.111.227892.
Article CAS PubMed Google Scholar
Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature. 1997;389:990–4. https://doi.org/10.1038/40187.
Article CAS PubMed Google Scholar
Masumoto A, Hirooka Y, Shimokawa H, Hironaga K, Setoguchi S, Takeshita A. Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. Hypertension. 2001;38:1307–10. https://doi.org/10.1161/hy1201.096541.
Article CAS PubMed Google Scholar
Shimokawa H, Sunamura S, Satoh K. RhoA/Rho-kinase in the cardiovascular system. Circ Res. 2016;118:352–66. https://doi.org/10.1161/CIRCRESAHA.115.306532.
Article CAS PubMed Google Scholar
Nohria A, Grunert ME, Rikitake Y, Noma K, Prsic A, Ganz P, Liao JK, Creager MA. Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. Circ Res. 2006;99:1426–32. https://doi.org/10.1161/01.RES.0000251668.39526.c7.
Article CAS PubMed PubMed Central Google Scholar
Kureishi Y, Kobayashi S, Amano M, Kimura K, Kanaide H, Nakano T, Kaibuchi K, Ito M. Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem. 1997;272:12257–60. https://doi.org/10.1074/jbc.272.19.12257.
Article CAS PubMed Google Scholar
Kimura K, Ito M, Amano M, et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science. 1996;273:245–8. https://doi.org/10.1126/science.273.5272.245.
Article CAS PubMed Google Scholar
Bussemaker E, Pistrosch F, Forster S, Herbrig K, Gross P, Passauer J, Brandes RP. Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide. Am J Physiol Heart Circ Physiol. 2007;293:H541–7. https://doi.org/10.1152/ajpheart.00770.2006.
Article CAS PubMed Google Scholar
Lang JA, Jennings JD, Holowatz LA, Kenney WL. Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling. Am J Physiol Heart Circ Physiol. 2009;297:H1792–7. https://doi.org/10.1152/ajpheart.00509.2009.
Article CAS PubMed PubMed Central Google Scholar
Noma K, Goto C, Nishioka K, et al. Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. J Am Coll Cardiol. 2007;49:698–705. https://doi.org/10.1016/j.jacc.2006.06.082.
Article CAS PubMed PubMed Central Google Scholar
Boutouyrie P, Chowienczyk P, Humphrey JD, Mitchell GF. Arterial stiffness and cardiovascular risk in hypertension. Circ Res. 2021;128:864–86. https://doi.org/10.1161/CIRCRESAHA.121.318061.
Article CAS PubMed Google Scholar
Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part III: cellular and molecular clues to heart and arterial aging. Circulation. 2003;107:490–7. https://doi.org/10.1161/01.cir.0000048894.99865.02.
Ming XF, Viswambharan H, Barandier C, Ruffieux J, Kaibuchi K, Rusconi S, Yang Z. Rho GTPase/Rho kinase negatively regulates endothelial nitric oxide synthase phosphorylation through the inhibition of protein kinase B/Akt in human endothelial cells. Mol Cell Biol. 2002;22:8467–77. https://doi.org/10.1128/MCB.22.24.8467-8477.2002.
Article CAS PubMed PubMed Central Google Scholar
Racine ML, Terwoord JD, Ketelhut NB, Bachman NP, Richards JC, Luckasen GJ, Dinenno FA. Rho-kinase inhibition improves haemodynamic responses and circulating ATP during hypoxia and moderate intensity handgrip exercise in healthy older adults. J Physiol. 2022;600:3265–85. https://doi.org/10.1113/JP282730.
Article CAS PubMed Google Scholar
Shibuya M, Hirai S, Seto M, Satoh S, Ohtomo E, Fasudil Ischemic Stroke Study G. Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. J Neurol Sci. 2005;238:31–9. https://doi.org/10.1016/j.jns.2005.06.003.
Article CAS PubMed Google Scholar
Limberg JK, Casey DP, Trinity JD, Nicholson WT, Wray DW, Tschakovsky ME, Green DJ, Hellsten Y, Fadel PJ, Joyner MJ, Padilla J. Assessment of resistance vessel function in human skeletal muscle: guidelines for experimental design, Doppler ultrasound, and pharmacology. Am J Physiol Heart Circ Physiol. 2020;318:H301–25. https://doi.org/10.1152/ajpheart.00649.2019.
Article CAS PubMed Google Scholar
Shoji T, Nakagomi A, Okada S, Ohno Y, Kobayashi Y. Invasive validation of a novel brachial cuff-based oscillometric device (SphygmoCor XCEL) for measuring central blood pressure. J Hypertens. 2017;35:69–75. https://doi.org/10.1097/HJH.0000000000001135.
Article CAS PubMed Google Scholar
Bachman NP, Terwoord JD, Richards JC, Braun B, Green CP, Luckasen GJ, Dinenno FA. Comprehensive assessment of cardiovascular structure and function and disease risk in middle-aged ultra-endurance athletes. Atherosclerosis. 2021;320:105–11. https://doi.org/10.1016/j.atherosclerosis.2020.11.030.
Article CAS PubMed Google Scholar
Woolf EK, Terwoord JD, Litwin NS, et al. Daily blueberry consumption for 12 weeks improves endothelial function in postmenopausal women with above-normal blood pressure through reductions in oxidative stress: a randomized controlled trial. Food Funct. 2023;14:2621–41. https://doi.org/10.1039/d3fo00157a.
Article CAS PubMed Google Scholar
Hwang MH, Yoo JK, Kim HK, Hwang CL, Mackay K, Hemstreet O, Nichols WW, Christou DD. Validity and reliability of aortic pulse wave velocity and augmentation index determined by the new cuff-based SphygmoCor Xcel. J Hum Hypertens. 2014;28:475–81. https://doi.org/10.1038/jhh.2013.144.
Article CAS PubMed Google Scholar
Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H, European Network for Non-invasive Investigation of Large A. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J. 2006;27:2588–605. https://doi.org/10.1093/eurheartj/ehl254.
Millasseau SC, Stewart AD, Patel SJ, Redwood SR, Chowienczyk PJ. Evaluation of carotid-femoral pulse wave velocity: influence of timing algorithm and heart rate. Hypertension. 2005;45:222–6. https://doi.org/10.1161/01.HYP.0000154229.97341.d2.
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