Jack CR Jr, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement. 2018;14(4):535–62.

Article  PubMed  Google Scholar 

Lane CA, Hardy J, Schott JM. Alzheimer’s disease. Eur J Neurol. 2018;25(1):59–70.

Article  CAS  PubMed  Google Scholar 

Braak H, Thal DR, Ghebremedhin E, Del Tredici K. Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years. J Neuropathol Exp Neurol. 2011;70(11):960–9.

Article  CAS  PubMed  Google Scholar 

Samuels ER, Szabadi E. Functional neuroanatomy of the noradrenergic locus coeruleus: its roles in the regulation of arousal and autonomic function part I: principles of functional organisation. Curr Neuropharmacol. 2008;6(3):235–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pooler AM, Polydoro M, Maury EA, Nicholls SB, Reddy SM, Wegmann S, et al. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease. Acta Neuropathol Commun. 2015;3:14.

Article  PubMed  PubMed Central  Google Scholar 

Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, et al. The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes. Brain. 2019;142(10):3230–42.

Article  PubMed  PubMed Central  Google Scholar 

Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, et al. Locus coeruleus volume and cell population changes during Alzheimer’s disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2017;13(3):236–46.

Article  PubMed  Google Scholar 

Gilvesy A, Husen E, Magloczky Z, Mihaly O, Hortobágyi T, Kanatani S, et al. Spatiotemporal characterization of cellular tau pathology in the human locus coeruleus-pericoerulear complex by three-dimensional imaging. Acta Neuropathol. 2022;144(4):651–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rorabaugh JM, Chalermpalanupap T, Botz-Zapp CA, Fu VM, Lembeck NA, Cohen RM, et al. Chemogenetic locus coeruleus activation restores reversal learning in a rat model of Alzheimer’s disease. Brain. 2017;140(11):3023–38.

Article  PubMed  PubMed Central  Google Scholar 

La Joie R, Visani AV, Baker SL, Brown JA, Bourakova V, Cha J, et al. Prospective longitudinal atrophy in Alzheimer's disease correlates with the intensity and topography of baseline tau-PET. Sci Transl Med. 2020;12(524):eaau5732.

Robertson IH. A noradrenergic theory of cognitive reserve: implications for Alzheimer’s disease. Neurobiol Aging. 2013;34(1):298–308.

Article  CAS  PubMed  Google Scholar 

Mather M, Harley CW. The Locus Coeruleus: Essential for Maintaining Cognitive Function and the Aging Brain. Trends Cogn Sci. 2016;20(3):214–26.

Article  PubMed  PubMed Central  Google Scholar 

Bachman SL, Dahl MJ, Werkle-Bergner M, Duzel S, Forlim CG, Lindenberger U, et al. Locus coeruleus MRI contrast is associated with cortical thickness in older adults. Neurobiol Aging. 2021;100:72–82.

Article  CAS  PubMed  Google Scholar 

Elman JA, Puckett OK, Hagler DJ, Pearce RC, Fennema-Notestine C, Hatton SN, Lyons MJ, McEvoy LK, Panizzon MS, Reas ET, Dale AM, Franz CE, Kremen WS. Associations Between MRI-Assessed Locus Coeruleus Integrity and Cortical Gray Matter Microstructure. Cereb Cortex. 2022;32(19):4191–203.

Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, et al. Harvard Aging Brain Study: Dataset and accessibility. Neuroimage. 2017;144(Pt B):255–8.

Article  PubMed  Google Scholar 

Morris J. The clinical dementia rating (CDR): current version and scoring rules. Neurology. 1993;43:2412–4.

Article  CAS  PubMed  Google Scholar 

Yesavage JA, Sheikh JI. 9/Geriatric depression scale (GDS) recent evidence and development of a shorter version. Clin Gerontol. 1986;5(1-2):165–73.

Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12(3):189–98.

Article  CAS  PubMed  Google Scholar 

Powel J. Wechsler memory scale-revised: David A. Wechsler. New York: The Psychological Corporation. Harcourt Brace Jovanovich, Inc, 1987. 150 pp. Arch Clin Neuropsychol. 1988;3(4):397–403.

The Belmont Report. Ethical principles and guidelines for the protection of human subjects of research. J Am Coll Dent. 2014;81(3):4–13.

Google Scholar 

Dale AM, Fischl B, Sereno MI. Cortical Surface-Based Analysis: I. Segmentation and Surface Reconstruction NeuroImage (Orlando, Fla). 1999;9(2):179–94.

CAS  Google Scholar 

Jacobs HIL, Becker JA, Kwong K, Engels-Dominguez E, Prokopiou PC, Papp KV, et al. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline. Science Translational Medicine. 2021;13(612):eabj2511.

Article  PubMed  PubMed Central  Google Scholar 

Keren NI, Taheri S, Vazey EM, Morgan PS, Granholm AC, Aston-Jones GS, et al. Histologic validation of locus coeruleus MRI contrast in post-mortem tissue. Neuroimage. 2015;113:235–45.

Article  PubMed  Google Scholar 

Ohm TG, Busch C, Bohl J. Unbiased estimation of neuronal numbers in the human nucleus coeruleus during aging. Neurobiol Aging. 1997;18(4):393–9.

Article  CAS  PubMed  Google Scholar 

German DC, Walker BS, Manaye K, Smith WK, Woodward DJ, North AJ. The human locus coeruleus: computer reconstruction of cellular distribution. J Neurosci. 1988;8(5):1776–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernandes P, Regala J, Correia F, Goncalves-Ferreira AJ. The human locus coeruleus 3-D stereotactic anatomy. Surg Radiol Anat. 2012;34(10):879–85.

Article  CAS  PubMed  Google Scholar 

Braak H, Del Tredici K. Neuroanatomy and pathology of sporadic Alzheimer's disease. Adv Anat Embryol Cell Biol. 2015;215:1–162.

Desikan RS, Ségonne F, Fischl B, Quinn BT, Dickerson BC, Blacker D, et al. An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest. NeuroImage (Orlando, Fla). 2006;31(3):968–80.

Article  Google Scholar 

Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, et al. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016;79(1):110–9.

Article  PubMed  Google Scholar 

Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, et al. Amyloid- Delta b associated cortical thinning in clinically normal elderly. Ann Neurol. 2011;69(6):1032–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greve DN, Svarer C, Fisher PM, Feng L, Hansen AE, Baare W, et al. Cortical surface-based analysis reduces bias and variance in kinetic modeling of brain PET data. NeuroImage (Orlando, Fla). 2014;92:225–36.

Article  Google Scholar 

Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, et al. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. 2020;94(18):e1916–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maass A, Landau S, Baker SL, Horng A, Lockhart SN, La Joie R, et al. Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer’s disease. Neuroimage. 2017;157:448–63.

Article  CAS  PubMed  Google Scholar 

Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, et al. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Mol Psychiatry. 2021;26(12):7813–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, et al. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. JAMA Neurol. 2017;74(12):1455–63.

Article  PubMed  PubMed Central