Post-sepsis psychiatric disorder: Pathophysiology, prevention, and treatment

Rudd KE, Johnson SC, Agesa KM et al (2020) Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the global burden of disease study. Lancet 395:200–211. https://doi.org/10.1016/S0140-6736(19)32989-7

Article  PubMed  PubMed Central  Google Scholar 

Fleischmann C, Scherag A, Adhikari NK et al (2016) Assessment of global incidence and mortality of hospital-treated sepsis. current estimates and limitations. Am J Respir Crit Care Med 193:259–272. https://doi.org/10.1164/rccm.201504-0781OC

Article  CAS  PubMed  Google Scholar 

Mostel Z, Perl A, Marck M et al (2019) Post-sepsis syndrome - an evolving entity that afflicts survivors of sepsis. Mol Med 26:6. https://doi.org/10.1186/s10020-019-0132-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angus DC (2010) The lingering consequences of sepsis: a hidden public health disaster? JAMA 304:1833–1834. https://doi.org/10.1001/jama.2010.1546

Article  CAS  PubMed  Google Scholar 

Jones C, Griffiths RD (2013) Mental and physical disability after sepsis. Minerva Anestesiol 79:1306–1312

CAS  PubMed  Google Scholar 

Prescott HC, Angus DC (2018) Enhancing recovery from sepsis: a review. JAMA 319:62–75. https://doi.org/10.1001/jama.2017.17687

Article  PubMed  PubMed Central  Google Scholar 

Maldonado JR (2018) Delirium pathophysiology: an updated hypothesis of the etiology of acute brain failure. Int J Geriatr Psychiatry 33:1428–1457. https://doi.org/10.1002/gps.4823

Article  PubMed  Google Scholar 

Iwashyna TJ, Ely EW, Smith DM, Langa KM (2010) Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 304:1787–1794. https://doi.org/10.1001/jama.2010.1553

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fleischmann-Struzek C, Rose N, Freytag A et al (2021) Epidemiology and costs of postsepsis morbidity, nursing care dependency, and mortality in Germany, 2013 to 2017. JAMA Netw Open 4:e2134290. https://doi.org/10.1001/jamanetworkopen.2021.34290

Article  PubMed  PubMed Central  Google Scholar 

Kim Y, Jin Y, Jin T, Lee SM (2020) Risk factors and outcomes of sepsis-associated delirium in intensive care unit patients: a secondary data analysis. Intensive Crit Care Nurs 59:102844. https://doi.org/10.1016/j.iccn.2020.102844

Article  PubMed  Google Scholar 

Yamamoto T, Mizobata Y, Kawazoe Y et al (2020) Incidence, risk factors, and outcomes for sepsis-associated delirium in patients with mechanical ventilation: a sub-analysis of a multicenter randomized controlled trial. J Crit Care 56:140–144. https://doi.org/10.1016/j.jcrc.2019.12.018

Article  CAS  PubMed  Google Scholar 

Zhang Y, Hu J, Hua T et al (2023) Development of a machine learning-based prediction model for sepsis-associated delirium in the intensive care unit. Sci Rep 13:12697. https://doi.org/10.1038/s41598-023-38650-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatch R, Young D, Barber V et al (2018) Anxiety, depression and post traumatic stress disorder after critical illness: a UK-wide prospective cohort study. Crit Care 22:310. https://doi.org/10.1186/s13054-018-2223-6

Article  PubMed  PubMed Central  Google Scholar 

Calsavara AJ, Costa PA, Nobre V, Teixeira AL (2021) Prevalence and risk factors for post-traumatic stress, anxiety, and depression in sepsis survivors after ICU discharge. Braz J Psychiatry 43:269–276. https://doi.org/10.1590/1516-4446-2020-0986

Article  PubMed  Google Scholar 

Oh TK, Park HY, Song IA (2021) Depression and long-term survival among south korean sepsis survivors: a Nationwide cohort study from 2011 to 2014. Crit Care Med 49:1470–1480. https://doi.org/10.1097/CCM.0000000000005030

Article  PubMed  Google Scholar 

Boede M, Gensichen JS, Jackson JC et al (2021) Trajectories of depression in sepsis survivors: an observational cohort study. Crit Care 25:161. https://doi.org/10.1186/s13054-021-03577-7

Article  PubMed  PubMed Central  Google Scholar 

Cash A, Theus MH (2020) Mechanisms of blood-brain barrier dysfunction in traumatic brain injury. Int J Mol Sci 21:3344. https://doi.org/10.3390/ijms21093344

Article  CAS  PubMed  PubMed Central  Google Scholar 

Galea I (2021) The blood-brain barrier in systemic infection and inflammation. Cell Mol Immunol 18:2489–2501. https://doi.org/10.1038/s41423-021-00757-x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu XE, Liu L, Wang YC et al (2019) Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis. Brain Behav Immun 80:859–870. https://doi.org/10.1016/j.bbi.2019.05.038

Article  CAS  PubMed  Google Scholar 

Silva AYO, Amorim ÉA, Barbosa-Silva MC et al (2020) Mesenchymal stromal cells protect the blood-brain barrier, reduce astrogliosis, and prevent cognitive and behavioral alterations in surviving septic mice. Crit Care Med 48:e290–e298. https://doi.org/10.1097/ccm.0000000000004219

Article  CAS  PubMed  Google Scholar 

Shulyatnikova T, Verkhratsky A (2020) Astroglia in sepsis associated encephalopathy. Neurochem Res 45:83–99. https://doi.org/10.1007/s11064-019-02743-2

Article  CAS  PubMed  Google Scholar 

Skelly DT, Hennessy E, Dansereau MA, Cunningham C (2013) A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1β, [corrected] TNF-α and IL-6 challenges in C57BL/6 mice. PLoS ONE 8:e69123. https://doi.org/10.1371/journal.pone.0069123

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sekino N, Selim M, Shehadah A (2022) Sepsis-associated brain injury: underlying mechanisms and potential therapeutic strategies for acute and long-term cognitive impairments. J Neuroinflammation 19:101. https://doi.org/10.1186/s12974-022-02464-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu M, Mei XL, Zhao YN (2021) Sepsis and cerebral dysfunction: BBB damage, neuroinflammation, oxidative stress, apoptosis and autophagy as key mediators and the potential therapeutic approaches. Neurotox Res 39:489–503. https://doi.org/10.1007/s12640-020-00270-5

Article  CAS  PubMed  Google Scholar 

Calsavara AC, Rodrigues DH, Miranda AS et al (2013) Late anxiety-like behavior and neuroinflammation in mice subjected to sublethal polymicrobial sepsis. Neurotox Res 24:103–108. https://doi.org/10.1007/s12640-012-9364-1

Article  CAS  PubMed  Google Scholar 

Anderson ST, Commins S, Moynagh PN, Coogan AN (2015) Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse. Brain Behav Immun 43:98–109. https://doi.org/10.1016/j.bbi.2014.07.007

Article  CAS  PubMed  Google Scholar 

Zhu W, Cao FS, Feng J et al (2017) NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide. Neuroscience 343:77–84. https://doi.org/10.1016/j.neuroscience.2016.11.037

Article  CAS  PubMed  Google Scholar 

Fang H, Wang Y, Deng J et al (2022) Sepsis-Induced Gut Dysbiosis Mediates the Susceptibility to Sepsis-Associated Encephalopathy in Mice. mSystems 7:e0139921. https://doi.org/10.1128/msystems.01399-21

留言 (0)

沒有登入
gif