Thomas R, Wang W, Su D-M. Contributions of age-related thymic involution to immunosenescence and inflammaging. Immun Ageing. 2020;17:2.
Article PubMed PubMed Central Google Scholar
Mittelbrunn M, Kroemer G. Hallmarks of T cell aging. Nat Immunol. 2021;22:687–98.
Article CAS PubMed Google Scholar
Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF, et al. Changes in thymic function with age and during the treatment of HIV infection. Nature. 1998;396:690.
Article CAS PubMed Google Scholar
Geenen V, Poulin JF, Dion ML, Martens H, Castermans E, Hansenne I, et al. Quantification of T cell receptor rearrangement excision circles to estimate thymic function: an important new tool for endocrine-immune physiology. J Endocrinol. 2003;176:305–11.
Article CAS PubMed Google Scholar
Ringhoffer S, Rojewski M, Dohner H, Bunjes D, Ringhoffer M. T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/betaTREC ratio and thymic naive T cells. Haematologica. 2013;98:1600–8.
Article CAS PubMed PubMed Central Google Scholar
Clave E, Araujo IL, Alanio C, Patin E, Bergstedt J, Urrutia A, et al. Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus. Sci Transl Med. 2018;10:eaao2966.
Cho S, Jung S-E, Hong SR, Lee EH, Lee JH, Lee SD, et al. Independent validation of DNA-based approaches for age prediction in blood. Forensic Sci Int: Genet. 2017;29:250–6.
Article CAS PubMed Google Scholar
Richardson MW, Sverstiuk A, Hendel H, Cheung TW, Zagury JF, Rappaport J. Analysis of telomere length and thymic output in fast and slow/non-progressors with HIV infection. Biomedicine Pharmacother. 2000;54:21–31.
McCullough KM, Katrinli S, Hartmann J, Lori A, Klengel C, Missig G, et al. Blood levels of T-cell receptor excision circles (TRECs) provide an index of exposure to traumatic stress in mice and humans. Transl Psychiatry. 2022;12:423.
Article CAS PubMed PubMed Central Google Scholar
Kooshesh KA, Foy BH, Sykes DB, Gustafsson K, Scadden DT. Health consequences of thymus removal in adults. N Engl J Med. 2023;389:406–17.
Article PubMed PubMed Central Google Scholar
Ellison LF, Xie L, Sung L. Trends in paediatric cancer survival in Canada, 1992 to 2017. Health Rep. 2021;32:3–16.
Fulbright JM, Raman S, McClellan WS, August KJ. Late effects of childhood leukemia therapy. Curr Hematologic Malignancy Rep. 2011;6:195–205.
Marcoux S, Drouin S, Laverdiere C, Alos N, Andelfinger GU, Bertout L, et al. The PETALE study: Late adverse effects and biomarkers in childhood acute lymphoblastic leukemia survivors. Pediatr Blood Cancer. 2017;64:e26361.
Ariffin H, Azanan MS, Ghafar SSA, Oh L, Lau KH, Thirunavakarasu T, et al. Young adult survivors of childhood acute lymphoblastic leukemia show evidence of chronic inflammation and cellular aging. Cancer. 2017;123:4207–14.
Article CAS PubMed Google Scholar
Ness KK, Kirkland JL, Gramatges MM, Wang Z, Kundu M, McCastlain K, et al. Premature physiologic aging as a paradigm for understanding increased risk of adverse health across the lifespan of survivors of childhood cancer. J Clin Oncol. 2018;36:2206–15.
Article CAS PubMed PubMed Central Google Scholar
Ness KK, Krull KR, Jones KE, Mulrooney DA, Armstrong GT, Green DM, et al. Physiologic frailty as a sign of accelerated aging among adult survivors of childhood cancer: a report from the St Jude Lifetime cohort study. J Clin Oncol. 2013;31:4496.
Article PubMed PubMed Central Google Scholar
Morel S, Leveille P, Samoilenko M, Franco A, England J, Malaquin N, et al. Biomarkers of cardiometabolic complications in survivors of childhood acute lymphoblastic leukemia. Sci Rep. 2020;10:21507.
Article CAS PubMed PubMed Central Google Scholar
Kudlow BA, Kennedy BK, Monnat RJ. Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases. Nat Rev Mol Cell Biol. 2007;8:394–404.
Article CAS PubMed Google Scholar
Fagnoni FF, Lozza L, Zibera C, Zambelli A, Ponchio L, Gibelli N, et al. T-cell dynamics after high-dose chemotherapy in adults: elucidation of the elusive CD8+ subset reveals multiple homeostatic T-cell compartments with distinct implications for immune competence. Immunology. 2002;106:27–37.
Article CAS PubMed PubMed Central Google Scholar
Marcoux S, Le ON, Langlois-Pelletier C, Laverdiere C, Hatami A, Robaey P, et al. Expression of the senescence marker p16INK4a in skin biopsies of acute lymphoblastic leukemia survivors: a pilot study. Radiat Oncol. 2013;8:252.
Article PubMed PubMed Central Google Scholar
Velardi E, Tsai JJ, van den Brink MRM. T cell regeneration after immunological injury. Nat Rev Immunol. 2021;21:277–91.
Article CAS PubMed Google Scholar
Verma R, Foster RE, Horgan K, Mounsey K, Nixon H, Smalle N, et al. Lymphocyte depletion and repopulation after chemotherapy for primary breast cancer. Breast Cancer Res. 2016;18:10.
Article PubMed PubMed Central Google Scholar
Wilson CL, Chemaitilly W, Jones KE, Kaste SC, Srivastava DK, Ojha RP, et al. Modifiable factors associated with aging phenotypes among adult survivors of childhood acute lymphoblastic leukemia. J Clin Oncol. 2016;34:2509–15.
Article CAS PubMed PubMed Central Google Scholar
Carleton N, McAuliffe PF. Are the chronological age cutoffs used in clinical oncology guidelines biologically meaningful? Nat Rev Clin Oncol. 2022;19:745–6.
Article PubMed PubMed Central Google Scholar
Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, et al. Measuring aging and identifying aging phenotypes in cancer survivors. JNCI: J Natl Cancer Inst. 2019;111:1245–54.
Article CAS PubMed PubMed Central Google Scholar
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, et al. Ink4a/Arf expression is a biomarker of aging. J Clin Investig. 2004;114:1299–307.
Article CAS PubMed PubMed Central Google Scholar
Smitherman AB, Wood WA, Mitin N, Miller VLA, Deal AM, Davis IJ, et al. Accelerated aging among childhood, adolescent, and young adult cancer survivors is evidenced by increased expression of p16INK4a and frailty. Cancer. 2020;126:4975–83.
Article CAS PubMed Google Scholar
Song N, Li Z, Qin N, Howell CR, Wilson CL, Easton J, et al. Shortened leukocyte telomere length associates with an increased prevalence of chronic health conditions among survivors of childhood cancer: a report from the St. Jude Lifetime Cohort. Clin Cancer Res. 2020;26:2362–71.
Article CAS PubMed PubMed Central Google Scholar
Yousefzadeh MJ, Schafer MJ, Noren Hooten N, Atkinson EJ, Evans MK, Baker DJ, et al. Circulating levels of monocyte chemoattractant protein‐1 as a potential measure of biological age in mice and frailty in humans. Aging cell. 2018;17:e12706.
Qin N, Li Z, Song N, Wilson CL, Easton J, Mulder H, et al. Epigenetic age acceleration and chronic health conditions among adult survivors of childhood cancer. JNCI: J Natl Cancer Inst. 2021;113:597–605.
Silverman LB, Stevenson KE, O’Brien JE, Asselin BL, Barr RD, Clavell L, et al. Long-term results of Dana-Farber Cancer Institute ALL Consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985–2000). Leukemia. 2010;24:320–34.
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