Yang Q, et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr Rev. 2022;43(4):678–719.
Bulun SE. Uterine fibroids. N Engl J Med. 2013;369(14):1344–55.
Article CAS PubMed Google Scholar
Stewart EA, et al. Uterine fibroids. Nat Rev Dis Primers. 2016;2:16043.
Whynott RM, Vaught KCC, Segars JH. The effect of uterine fibroids on infertility: a systematic review. Semin Reprod Med. 2017;35(6):523–32.
Cheng Y, et al. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther. 2019;4:62.
Article PubMed PubMed Central Google Scholar
Jain AK, Barton MC. Bromodomain histone readers and cancer. J Mol Biol. 2017;429(13):2003–10.
Article CAS PubMed Google Scholar
Rodriguez RM, et al. Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer. J Mol Med (Berl). 2012;90(5):587–95.
Article CAS PubMed Google Scholar
Sahni JM, Keri RA. Targeting bromodomain and extraterminal proteins in breast cancer. Pharmacol Res. 2018;129:156–76.
Article CAS PubMed Google Scholar
Yang Q, Al-Hendy A. Non-coding RNAs: an important regulatory mechanism in pathogenesis of uterine fibroids. Fertil Steril. 2018;109(5):802–3.
Article PubMed PubMed Central Google Scholar
Chuang TD, Rehan A, Khorram O. Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis. Fertil Steril. 2021;115(1):238–47.
Article CAS PubMed Google Scholar
George JW, et al. Integrated epigenome, exome, and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids. Cell Rep. 2019;29(12):4069-4085 e6.
Article CAS PubMed PubMed Central Google Scholar
Moyo MB, Parker JB, Chakravarti D. Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas. Nat Commun. 2020;11(1):1019.
Article CAS PubMed PubMed Central Google Scholar
Yang Q, et al. Targeting class I histone deacetylases in human uterine leiomyosarcoma. Cells. 2022;11(23):3801.
Article CAS PubMed PubMed Central Google Scholar
Zhao S, et al. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010;327(5968):1000–4.
Article CAS PubMed PubMed Central Google Scholar
Fujisawa T, Filippakopoulos P. Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. 2017;18(4):246–62.
Article CAS PubMed Google Scholar
Ferri E, Petosa C, McKenna CE. Bromodomains: structure, function and pharmacology of inhibition. Biochem Pharmacol. 2016;106:1–18.
Article CAS PubMed Google Scholar
Hugle M, et al. Beyond the BET family: targeting CBP/p300 with 4-Acyl pyrroles. Angew Chem Int Ed Engl. 2017;56(41):12476–80.
Clegg MA, et al. Advancements in the development of non-BET bromodomain chemical probes. ChemMedChem. 2019;14(4):362–85.
Article CAS PubMed Google Scholar
Vichaikul S, et al. Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma. JCI Insight. 2022;7(9):e150871.
Wang Q, et al. Selectively targeting individual bromodomain: drug discovery and molecular mechanisms. Pharmacol Res. 2021;172:105804.
Article CAS PubMed Google Scholar
Zaware N, Zhou MM. Bromodomain biology and drug discovery. Nat Struct Mol Biol. 2019;26(10):870–9.
Article CAS PubMed PubMed Central Google Scholar
Kadoch C, et al. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013;45(6):592–601.
Article CAS PubMed PubMed Central Google Scholar
Ali MM, et al. Epigenetic modulation by targeting bromodomain containing protein 9 (BRD9): its therapeutic potential and selective inhibition. Int J Biol Macromol. 2023;230:123428.
Article CAS PubMed Google Scholar
Ali MM, et al. Identification of selective BRD9 inhibitor via integrated computational approach. Int J Mol Sci. 2022;23(21):13513.
Article CAS PubMed PubMed Central Google Scholar
Park SG, et al. Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells. Sci Rep. 2020;10(1):16330.
Article CAS PubMed PubMed Central Google Scholar
Bevill SM, et al. GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer. Mol Cancer Res. 2019;17(7):1503–18.
Article CAS PubMed PubMed Central Google Scholar
Martin LJ, et al. Structure-based design of an in vivo active selective BRD9 inhibitor. J Med Chem. 2016;59(10):4462–75.
Article CAS PubMed PubMed Central Google Scholar
Mason LD, et al. The BRD9/7 inhibitor TP-472 blocks melanoma tumor growth by suppressing ECM-mediated oncogenic signaling and inducing apoptosis. Cancers (Basel). 2021;13(21):5516.
Yang Q, et al. Bromodomain-containing protein 9 regulates signaling pathways and reprograms the epigenome in immortalized human uterine fibroid cells. Int J Mol Sci. 2024;25(2):905.
Article CAS PubMed PubMed Central Google Scholar
Carney SA, et al. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. Lab Invest. 2002;82(6):719–28.
Article CAS PubMed Google Scholar
Yang Q, et al. Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells. Cell Prolif. 2013;46(6):654–64.
Article CAS PubMed PubMed Central Google Scholar
Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.
Article PubMed PubMed Central Google Scholar
Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139–40.
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