Targeting Bromodomain-Containing Protein 9 in Human Uterine Fibroid Cells

Yang Q, et al. Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment. Endocr Rev. 2022;43(4):678–719.

Article  PubMed  Google Scholar 

Bulun SE. Uterine fibroids. N Engl J Med. 2013;369(14):1344–55.

Article  CAS  PubMed  Google Scholar 

Stewart EA, et al. Uterine fibroids. Nat Rev Dis Primers. 2016;2:16043.

Article  PubMed  Google Scholar 

Whynott RM, Vaught KCC, Segars JH. The effect of uterine fibroids on infertility: a systematic review. Semin Reprod Med. 2017;35(6):523–32.

Article  PubMed  Google Scholar 

Cheng Y, et al. Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials. Signal Transduct Target Ther. 2019;4:62.

Article  PubMed  PubMed Central  Google Scholar 

Jain AK, Barton MC. Bromodomain histone readers and cancer. J Mol Biol. 2017;429(13):2003–10.

Article  CAS  PubMed  Google Scholar 

Rodriguez RM, et al. Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer. J Mol Med (Berl). 2012;90(5):587–95.

Article  CAS  PubMed  Google Scholar 

Sahni JM, Keri RA. Targeting bromodomain and extraterminal proteins in breast cancer. Pharmacol Res. 2018;129:156–76.

Article  CAS  PubMed  Google Scholar 

Yang Q, Al-Hendy A. Non-coding RNAs: an important regulatory mechanism in pathogenesis of uterine fibroids. Fertil Steril. 2018;109(5):802–3.

Article  PubMed  PubMed Central  Google Scholar 

Chuang TD, Rehan A, Khorram O. Functional role of the long noncoding RNA X-inactive specific transcript in leiomyoma pathogenesis. Fertil Steril. 2021;115(1):238–47.

Article  CAS  PubMed  Google Scholar 

George JW, et al. Integrated epigenome, exome, and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids. Cell Rep. 2019;29(12):4069-4085 e6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moyo MB, Parker JB, Chakravarti D. Altered chromatin landscape and enhancer engagement underlie transcriptional dysregulation in MED12 mutant uterine leiomyomas. Nat Commun. 2020;11(1):1019.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Q, et al. Targeting class I histone deacetylases in human uterine leiomyosarcoma. Cells. 2022;11(23):3801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao S, et al. Regulation of cellular metabolism by protein lysine acetylation. Science. 2010;327(5968):1000–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujisawa T, Filippakopoulos P. Functions of bromodomain-containing proteins and their roles in homeostasis and cancer. Nat Rev Mol Cell Biol. 2017;18(4):246–62.

Article  CAS  PubMed  Google Scholar 

Ferri E, Petosa C, McKenna CE. Bromodomains: structure, function and pharmacology of inhibition. Biochem Pharmacol. 2016;106:1–18.

Article  CAS  PubMed  Google Scholar 

Hugle M, et al. Beyond the BET family: targeting CBP/p300 with 4-Acyl pyrroles. Angew Chem Int Ed Engl. 2017;56(41):12476–80.

Article  PubMed  Google Scholar 

Clegg MA, et al. Advancements in the development of non-BET bromodomain chemical probes. ChemMedChem. 2019;14(4):362–85.

Article  CAS  PubMed  Google Scholar 

Vichaikul S, et al. Inhibition of bromodomain extraterminal histone readers alleviates skin fibrosis in experimental models of scleroderma. JCI Insight. 2022;7(9):e150871.

Wang Q, et al. Selectively targeting individual bromodomain: drug discovery and molecular mechanisms. Pharmacol Res. 2021;172:105804.

Article  CAS  PubMed  Google Scholar 

Zaware N, Zhou MM. Bromodomain biology and drug discovery. Nat Struct Mol Biol. 2019;26(10):870–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kadoch C, et al. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Nat Genet. 2013;45(6):592–601.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ali MM, et al. Epigenetic modulation by targeting bromodomain containing protein 9 (BRD9): its therapeutic potential and selective inhibition. Int J Biol Macromol. 2023;230:123428.

Article  CAS  PubMed  Google Scholar 

Ali MM, et al. Identification of selective BRD9 inhibitor via integrated computational approach. Int J Mol Sci. 2022;23(21):13513.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Park SG, et al. Cytotoxic activity of bromodomain inhibitor NVS-CECR2-1 on human cancer cells. Sci Rep. 2020;10(1):16330.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bevill SM, et al. GSK2801, a BAZ2/BRD9 bromodomain inhibitor, synergizes with BET inhibitors to induce apoptosis in triple-negative breast cancer. Mol Cancer Res. 2019;17(7):1503–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin LJ, et al. Structure-based design of an in vivo active selective BRD9 inhibitor. J Med Chem. 2016;59(10):4462–75.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mason LD, et al. The BRD9/7 inhibitor TP-472 blocks melanoma tumor growth by suppressing ECM-mediated oncogenic signaling and inducing apoptosis. Cancers (Basel). 2021;13(21):5516.

Yang Q, et al. Bromodomain-containing protein 9 regulates signaling pathways and reprograms the epigenome in immortalized human uterine fibroid cells. Int J Mol Sci. 2024;25(2):905.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carney SA, et al. Immortalization of human uterine leiomyoma and myometrial cell lines after induction of telomerase activity: molecular and phenotypic characteristics. Lab Invest. 2002;82(6):719–28.

Article  CAS  PubMed  Google Scholar 

Yang Q, et al. Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells. Cell Prolif. 2013;46(6):654–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Love MI, Huber W, Anders S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 2014;15(12):550.

Article  PubMed  PubMed Central  Google Scholar 

Robinson MD, McCarthy DJ, Smyth GK. edgeR: a bioconductor package for differential expression analysis of digital gene expression data. Bioinformatics. 2010;26(1):139–40.

留言 (0)

沒有登入
gif