Veratrum steroidal alkaloids are highly intricate alkaloids possessing a C-nor-D-homo steroid skeleton connecting to the piperidine ring. Fascinated by the structural complexity and biological profile of the Veratrum steroidal alkaloids, the first synthesis of cyclopamine was accomplished in 2009 via a semi-synthetic approach. Very recently, the synthesis of Veratrum steroidal alkaloids has thrived featuring a convergent approach. In this Highlight, the synthetic strategy that accomplishes the highly functionalized, complex molecular architecture of Veratrum steroidal alkaloids is discussed, emphasizing the involved key reaction. We highlight the current state of the synthesis of Veratrum steroidal alkaloids and discuss future directions and opportunities of the convergent synthetic approach in complex natural product synthesis.

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