Necchi A, Pederzoli F, Bandini M, Spiess PE. Revolutionizing care for rare genitourinary tumours. Nat Rev Urol. 2021;18(2):69–70. https://doi.org/10.1038/s41585-020-00402-8. This article represents a significant contribution in the field of managing rare genitourinary tumors, as it pioneers a novel classification of these malignancies, highlighting advancements and innovations in their management.

Article  PubMed  Google Scholar 

Costa de Padua T, Sabino Marques Monteiro F, Necchi A, Spiess PE. Redefining rare genitourinary cancers: an initiative led by the global society of rare genitourinary tumors. Eur Urol. 2024; S0302–2838(24)00074–5. https://doi.org/10.1016/j.eururo.2024.02.005. This study spearheads an initiative, led by the Global Society of Rare Genitourinary Tumors, to redefine rare genitourinary cancers, addressing the critical need for improved understanding and management strategies in this challenging clinical area.

McCormick B, Dahmen A, Antar A, Baumgarten A, Dhillon J, Spiess PE. Rare urologic tumors. Curr Opin Urol. 2017;27(1):68–75. https://doi.org/10.1097/MOU.0000000000000356.

Article  PubMed  Google Scholar 

Amin MB, Young RH. Primary carcinomas of the urethra. Semin Diagn Pathol. 1997;14(2):147–60.

CAS  PubMed  Google Scholar 

Grivas PD, Davenport M, Montie JE, Kunju LP, Feng F, Weizer AZ. Urethral cancer. Hematol Oncol Clin North Am. 2012;26(6):1291–314. https://doi.org/10.1016/j.hoc.2012.08.006.

Article  PubMed  Google Scholar 

Jacob J, Necchi A, Grivas P, Hughes M, Sanford T, Mollapour M, Shapiro O, Talal A, Sokol E, Vergilio JA, Killian J, Lin D, Williams E, Tse J, Ramkissoon S, Severson E, Hemmerich A, Ferguson N, Edgerly C, Duncan D, Huang R, Chung J, Madison R, Alexander B, Venstrom J, Reddy P, McGregor K, Elvin J, Schrock A, Danziger N, Pavlick D, Ross J, Bratslavsky G. Comprehensive genomic profiling of histologic subtypes of urethral carcinomas. Urol Oncol. 2021;39(10):731.e1-731.e15. https://doi.org/10.1016/j.urolonc.2020.12.021. This study provides comprehensive genomic profiling of various histologic subtypes of urethral carcinomas, offering valuable insights into the molecular landscape of these tumors and potentially informing personalized treatment strategies for patients with this rare malignancy.

Article  CAS  PubMed  Google Scholar 

Patel M, Im J, Ivy A, Maraboyina S, Kim T. The epidemiology and role of surgery in the treatment of urethral clear cell carcinoma. Int Urol Nephrol. 2020;52(1):51–7. https://doi.org/10.1007/s11255-019-02289-w.

Article  CAS  PubMed  Google Scholar 

Karnes RJ, Breau RH, Lightner DJ. Surgery for urethral cancer. Urol Clin North Am. 2010;37(3):445–57. https://doi.org/10.1016/j.ucl.2010.04.011.

Article  PubMed  Google Scholar 

Gakis G, Witjes JA, Compérat E, Cowan NC, De Santis M, Lebret T, Ribal MJ, Sherif AM, European Association of Urology. EAU guidelines on primary urethral carcinoma. Eur Urol. 2013;64(5):823–30. https://doi.org/10.1016/j.eururo.2013.03.044.

Article  PubMed  Google Scholar 

Dayyani F, Hoffman K, Eifel P, Guo C, Vikram R, Pagliaro LC, Pettaway C. Management of advanced primary urethral carcinomas. BJU Int. 2014;114(1):25–31. https://doi.org/10.1111/bju.12630.

Article  PubMed  Google Scholar 

Janisch F, Abufaraj M, Fajkovic H, Kimura S, Iwata T, Nyirady P, Rink M, Shariat SF. Current disease management of primary urethral carcinoma. Eur Urol Focus. 2019;5(5):722–34. https://doi.org/10.1016/j.euf.2019.07.001.

Article  PubMed  Google Scholar 

Bruins HM, Visser O, Ploeg M, Hulsbergen-van de Kaa CA, Kiemeney LA, Witjes JA. The clinical epidemiology of urachal carcinoma: results of a large, population-based study. J Urol. 2012;188(4):1102–7. https://doi.org/10.1016/j.juro.2012.06.020.

Article  PubMed  Google Scholar 

Aggarwal A, Agarwal S, Pandey S, Sankhwar S. Urachal adenocarcinoma. BMJ Case Rep. 2018;2018:bcr2018226207. https://doi.org/10.1136/bcr-2018-226207.

Article  PubMed  PubMed Central  Google Scholar 

Cowan ML, Springer S, Nguyen D, Taheri D, Guner G, Mendoza Rodriguez MA, Wang Y, Kinde I, Del Carmen Rodriguez Pena M, VandenBussche CJ, Olson MT, Cunha I, Fujita K, Ertoy D, Kinzler K, Bivalacqua T, Papadopoulos N, Vogelstein B, Netto GJ. Detection of TERT promoter mutations in primary adenocarcinoma of the urinary bladder. Hum Pathol. 2016;53:8–13. https://doi.org/10.1016/j.humpath.2016.02.009.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cigliola A, Basnet A, Jacob JM, Bratslavsky G, Cheng L, Grivas P, Kamat AM, Spiess PE, Pavlick DC, Lin DI, Ross JS, Necchi A. Urachal (U) and non-urachal (NU) adenocarcinomas (adenoCA) of the bladder: a comparative comprehensive genomic profiling (CGP) study. J Clin Oncol. 2024;42(4_suppl):535–535.

Article  Google Scholar 

Siefker-Radtke AO, Gee J, Shen Y, Wen S, Daliani D, Millikan RE, Pisters LL. Multimodality management of urachal carcinoma: the M. D. Anderson Cancer Center experience. J Urol. 2003;169(4):1295–8. https://doi.org/10.1097/01.ju.0000054646.49381.01.

Article  PubMed  Google Scholar 

Siefker-Radtke A. Urachal carcinoma: surgical and chemotherapeutic options. Expert Rev Anticancer Ther. 2006;6(12):1715–21. https://doi.org/10.1586/14737140.6.12.1715.

Article  CAS  PubMed  Google Scholar 

Yanagihara Y, Tanji N, Miura N, Shirato A, Nishimura K, Fukumoto T, Azuma K, Miyauchi Y, Kikugawa T, Yokoyama M. Modified FOLFOX6 chemotherapy in patients with metastatic urachal cancer. Chemotherapy. 2013;59(6):402–6. https://doi.org/10.1159/000362400.

Article  CAS  PubMed  Google Scholar 

Kim MJ, Kim YS, Oh SY, Lee S, Choi YJ, Seol YM, Park MJ, Kim KH, Park LC, Kang JH, Hwang IG, Lee SI, Lim ST, Kim HS, Lim HY, Rha SY, Kim HJ. Retrospective analysis of palliative chemotherapy for the patients with bladder adenocarcinoma: Korean Cancer Study Group Genitourinary and Gynecology Cancer Committee. Korean J Intern Med. 2018;33(2):383–90. https://doi.org/10.3904/kjim.2015.162.

Article  PubMed  Google Scholar 

Moussa MJ, Chen AH, Grana AK, Gao J, Shah AY, Corn PG, Tannir NM, Goswami S, Wang J, Araujo JC, Kamat AM, Navai N, Pettaway CA, Adibi M, Czerniak B, Guo CC, Siefker-Radtke AO, Campbell MT, Alhalabi O. Clinical outcomes of frontline GemFLP in advanced urachal and non-urachal adenocarcinomas of the urinary tract: the MD Anderson Cancer Center (MDACC) experience. J Clin Oncol. 2024;42(4_suppl):630–630.

Article  Google Scholar 

Katafigiotis I, Sfoungaristos S, Duvdevani M, Mitsos P, Roumelioti E, Stravodimos K, Anastasiou I, Constantinides CA. Primary adenocarcinoma of the seminal vesicles. A review of the literature. Arch Ital Urol Androl. 2016;88(1):47–51. https://doi.org/10.4081/aiua.2016.1.47.

Article  PubMed  Google Scholar 

Stenzel P, Wettach G, Leroy X. Primary seminal vesicle carcinoma. Int J Surg Pathol. 2011;19(3):401–4. https://doi.org/10.1177/1066896911398359.

Article  PubMed  Google Scholar 

Bhat A, Banerjee I, Kryvenko ON, Satyanarayana R. Primary seminal vesicle adenocarcinoma: a lethal yet cryptic malignancy with review of literature. BMJ Case Rep. 2019;12(12):e232994. https://doi.org/10.1136/bcr-2019-232994.

Article  PubMed  PubMed Central  Google Scholar 

Terrisse S, Camblor ME, Vérine J, Gauthier H, Mongiat-Artus P, Culine S. Primary adenocarcinoma of the seminal vesicle. Rare Tumors. 2017;9(3):7074. https://doi.org/10.4081/rt.2017.7074. (Erratum in: Rare Tumors. 2019 May 03; 11:2036361319848842. Comblor, Maria Eugenia [corrected to Camblor, Maria Eugenia]).

Article  PubMed  PubMed Central  Google Scholar 

Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO classification of tumours of the urinary system and male genital organs-part B: prostate and bladder tumours. Eur Urol. 2016;70(1):106–19. https://doi.org/10.1016/j.eururo.2016.02.028.

Article  PubMed  Google Scholar 

Lobo N, Shariat SF, Guo CC, Fernandez MI, Kassouf W, Choudhury A, Gao J, Williams SB, Galsky MD, Taylor JA 3rd, Roupret M, Kamat AM. What is the significance of variant histology in urothelial carcinoma? Eur Urol Focus. 2020;6(4):653–63. https://doi.org/10.1016/j.euf.2019.09.003.

Article  PubMed  Google Scholar 

Fernández MI, Williams SB, Willis DL, Slack RS, Dickstein RJ, Parikh S, Chiong E, Siefker-Radtke AO, Guo CC, Czerniak BA, McConkey DJ, Shah JB, Pisters LL, Grossman HB, Dinney CP, Kamat AM. Clinical risk stratification in patients with surgically resectable micropapillary bladder cancer. BJU Int. 2017;119(5):684–91. https://doi.org/10.1111/bju.13689.

Article  PubMed  Google Scholar 

Witjes JA, Babjuk M, Bellmunt J, Bruins HM, De Reijke TM, De Santis M, Gillessen S, James N, Maclennan S, Palou J, Powles T, Ribal MJ, Shariat SF, Der Kwast TV, Xylinas E, Agarwal N, Arends T, et al. EAU-ESMO consensus statements on the management of advanced and variant bladder cancer-an international collaborative multistakeholder effort†: under the auspices of the EAU-ESMO guidelines committees. Eur Urol. 2020;77(2):223–50. https://doi.org/10.1016/j.eururo.2019.09.035. (Erratum in: Eur Urol. 2020 Jul;78(1):e48-e50).

Article  PubMed  Google Scholar 

Willis DL, Fernandez MI, Dickstein RJ, Parikh S, Shah JB, Pisters LL, Guo CC, Henderson S, Czerniak BA, Grossman HB, Dinney CP, Kamat AM. Clinical outcomes of cT1 micropapillary bladder cancer. J Urol. 2015;193(4):1129–34. https://doi.org/10.1016/j.juro.2014.09.092.

Article  PubMed  Google Scholar 

Hsieh MC, Sung MT, Chiang PH, Huang CH, Tang Y, Su YL. The Prognostic Impact of Histopathological Variants in Patients with Advanced Urothelial Carcinoma. PLoS ONE. 2015;10(6):e0129268. https://doi.org/10.1371/journal.pone.0129268.

Article