Fragkioudakis I, Tseleki G, Doufexi AE, Sakellari D. Current concepts on the pathogenesis of peri-implantitis: a narrative review. Eur J Dent. 2021;15:379–87. https://doi.org/10.1055/s-0040-1721903.

Article  PubMed  PubMed Central  Google Scholar 

Berglundh T, Armitage G, Araujo MG, Avila-Ortiz G, Blanco J, Camargo PM, Chen S, Cochran D, Derks J, Figuero E, Hämmerle CHF, Heitz-Mayfield LJA, Huynh-Ba G, Iacono V, Koo KT, Lambert F, McCauley L, Quirynen M, Renvert S, Salvi GE, Schwarz F, Tarnow D, Tomasi C, Wang HL, Zitzmann N. Peri-implant diseases and conditions: consensus report of workgroup 4 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions. J Clin Periodontol. 2018;45:S286–91. https://doi.org/10.1038/sj.bdj.2018.617.

Article  PubMed  Google Scholar 

Berglundh T, Lindhe J, Jonsson K, Ericsson I. The topography of the vascular systems in the periodontal and peri-implant tissues in the dog. J Clin Periodontol. 1994;21:189–93. https://doi.org/10.1111/j.1600-051x.1994.tb00302.x.

Article  CAS  PubMed  Google Scholar 

Schwarz F, Derks J, Monje A, Wang HL. Peri-implantitis. J Clin Periodontol. 2018;45:S246–66. https://doi.org/10.1111/jcpe.12954.

Article  PubMed  Google Scholar 

Ericsson I, Berglundh T, Marinello C, Liljenberg B, Lindhe J. Long-standing plaque and gingivitis at implants and teeth in the dog. Clin Oral Implants Res. 1992;3:99–103. https://doi.org/10.1034/j.1600-0501.1992.030301.x.

Article  CAS  PubMed  Google Scholar 

Romandini M, Lima C, Pedrinaci I, Araoz A, Soldini M, Sanz M. Clinical signs, symptoms, perceptions, and impact on quality of life in patients suffering from peri-implant diseases: a university-representative cross-sectional study. Clin Oral Implants Res. 2021;32:100–11. https://doi.org/10.1111/clr.13683.

Article  PubMed  Google Scholar 

Krüger-Genge A, Blocki A, Franke RP, Jung F. Vascular endothelial cell biology: an update. Int J Mol Sci. 2019;20:4411. https://doi.org/10.3390/ijms20184411.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sluiter TJ, van Buul JD, Huveneers S, Quax PHA, de Vries MR. Endothelial barrier function and leukocyte transmigration in atherosclerosis. Biomedicines. 2021;9:328. https://doi.org/10.3390/biomedicines9040328.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vestweber D. How leukocytes cross the vascular endothelium. Nat Rev Immunol. 2015;15:692–704. https://doi.org/10.1038/nri3908.

Article  CAS  PubMed  Google Scholar 

Cerutti C, Ridley AJ. Endothelial cell–cell adhesion and signaling. Exp Cell Res. 2017;358:31–8. https://doi.org/10.1016/j.yexcr.2017.06.003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol. 1997;24:658–68. https://doi.org/10.1111/j.1600-051x.1997.tb00247.x.

Article  PubMed  Google Scholar 

Villa O, Brookes SJ, Thiede B, Heijl L, Lyngstadaas SP, Reseland JE. Subfractions of enamel matrix derivative differentially influence cytokine secretion from human oral fibroblasts. J Tissue Eng. 2015;6:2041731415575857. https://doi.org/10.1177/2041731415575857.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bertl K, An N, Bruckmann C, Dard M, Andrukhov O, Matejka M, Rausch-Fan X. Effects of enamel matrix derivative on proliferation/viability, migration, and expression of angiogenic factor and adhesion molecules in endothelial cells in vitro. J Periodontol. 2009;80:1622–30. https://doi.org/10.1902/jop.2009.090157.

Article  CAS  PubMed  Google Scholar 

Jose EP, Paul P, Reche A. Soft tissue management around the dental implant: a comprehensive review. Cureus. 2023;15:e48042. https://doi.org/10.7759/cureus.48042.

Article  PubMed  PubMed Central  Google Scholar 

Tsubokawa M, Sato S. In vitro analysis of human periodontal microvascular endothelial cells. J Periodontol. 2014;85:1135–42. https://doi.org/10.1902/jop.2013.130209.

Article  CAS  PubMed  Google Scholar 

Persson GR, Renvert S. Cluster of bacteria associated with peri-implantitis. Clin Implant Dent Relat Res. 2014;16:783–93. https://doi.org/10.1111/cid.12052.

Article  PubMed  Google Scholar 

Belibasakis GN, Manoil D. Microbial community-driven etiopathogenesis of peri-implantitis. J Dent Res. 2021;100:21–8. https://doi.org/10.1177/0022034520949851.

Article  CAS  PubMed  Google Scholar 

Dhaidan NI, Taha GI. The role of lipopolysaccharide in initiation and progression of peri-implant mucositis. J Med Chem Sci. 2023;6:402–9. https://doi.org/10.26655/JMCHEMSCI.2023.2.20.

Article  CAS  Google Scholar 

Pussinen PJ, Kopra E, Pietiäinen M, Lehto M, Zaric S, Paju S, Salminen A. Periodontitis and cardiometabolic disorders: the role of lipopolysaccharide and endotoxemia. Periodontol. 2000;2022(89):19–40. https://doi.org/10.1111/prd.12433.

Article  Google Scholar 

Wang X, Liu Y, Zhang S, Ouyang X, Wang Y, Jiang Y, An N. Crosstalk between Akt and NF-κB pathway mediates inhibitory effect of gas6 on monocytes-endothelial cells interactions stimulated by P. gingivalis-LPS. J Cell Mol Med. 2020;24:7979–90. https://doi.org/10.1111/jcmm.15430.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Xu X, Jin H, Yang X, Gu Q, Liu K. Effects of a thrombomodulin-derived peptide on monocyte adhesion and intercellular adhesion molecule-1 expression in lipopolysaccharide-induced endothelial cells. Mol Vis. 2013;19:203–12. PMID: 23401649; PMCID: PMC3566899.

Zitzmann NU, Berglundh T, Marinello CP, Lindhe J. Expression of endothelial adhesion molecules in the alveolar ridge mucosa, gingiva and periimplant mucosa. J Clin Periodontol. 2002;29:490–5. https://doi.org/10.1034/j.1600-051X.2002.290603.

Article  CAS  PubMed  Google Scholar 

Yu H, Huang X, Ma Y, Gao M, Wang O, Gao T, Shen Y, Liu X. Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions. Int J Biol Sci. 2013;9:966–79. https://doi.org/10.7150/ijbs.6996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aghajanian A, Wittchen ES, Allingham MJ, Garrett TA, Burridge K. Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration. J Thromb Haemost. 2008;6:1453–60. https://doi.org/10.1111/j.1538-7836.2008.03087.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolburg H, Lippoldt A. Tight junctions of the blood-brain barrier: development, composition and regulation. Vascul Pharmacol. 2002;38:323–37. https://doi.org/10.1016/S1537-1891(02)00200-8.

Article  CAS  PubMed  Google Scholar 

Srinivasan B, Kolli AR, Esch MB, Abaci HE, Shuler ML, Hickman JJ. TEER measurement techniques for in vitro barrier model systems. J Lab Autom. 2015;20:107–26. https://doi.org/10.1177/221106821456.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dewi BE, Takasaki T, Kurane I. In vitro assessment of human endothelial cell permeability: effects of inflammatory cytokines and dengue virus infection. J Virol Methods. 2004;121:171–80. https://doi.org/10.1016/j.jviromet.2004.06.013.

Article  CAS  PubMed  Google Scholar 

Furuse M, Itoh M, Hirase T, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S. Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions. J Cell Biol. 1994;127:1617–26. https://doi.org/10.1083/jcb.127.6.1617.

Article  CAS  PubMed  Google Scholar 

Gottardi CJ, Arpin M, Fanning AS, Louvard D. The junction-associated protein, zonula occludens-1, localizes to the nucleus before the maturation and during the remodeling of cell–cell contacts. Proc Natl Acad Sci U S A. 1996;93:10779–84. https://doi.org/10.1073/pnas.93.20.10779.

Article