Targeting FGFR for cancer therapy

Xue WJ, Li MT, Chen L, Sun LP, Li YY. Recent developments and advances of FGFR as a potential target in cancer. Future Med Chem. 2018;10(17):2109–26.

Article  CAS  PubMed  Google Scholar 

Regeenes R, Silva PN, Chang HH, Arany EJ, Shukalyuk AI, Audet J, et al. Fibroblast growth factor receptor 5 (FGFR5) is a co-receptor for FGFR1 that is up-regulated in beta-cells by cytokine-induced inflammation. J Biol Chem. 2018;293(44):17218–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Trueb B. Biology of FGFRL1, the fifth fibroblast growth factor receptor. Cell Mol Life Sci. 2011;68(6):951–64.

Article  CAS  PubMed  Google Scholar 

Wiedemann M, Trueb B. Characterization of a novel protein (FGFRL1) from human cartilage related to FGF receptors. Genomics. 2000;69(2):275–9.

Article  CAS  PubMed  Google Scholar 

Mikhaylenko DS, Alekseev BY, Zaletaev DV, Goncharova RI, Nemtsova MV. Structural alterations in human fibroblast growth factor receptors in carcinogenesis. Biochemistry (Mosc). 2018;83(8):930–43.

Article  CAS  PubMed  Google Scholar 

Babina IS, Turner NC. Advances and challenges in targeting FGFR signalling in cancer. Nat Rev Cancer. 2017;17(5):318–32.

Article  CAS  PubMed  Google Scholar 

Turner N, Grose R. Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer. 2010;10(2):116–29.

Article  CAS  PubMed  Google Scholar 

Gnatenko DA, Kopantzev EP, Sverdlov ED. Fibroblast growth factors and their effects in pancreas organogenesis. Biomed Khim. 2017;63(3):211–8.

Article  CAS  PubMed  Google Scholar 

Katoh M. FGFR inhibitors: effects on cancer cells, tumor microenvironment and whole-body homeostasis. Int J Mol Med. 2016;38(1):3–15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tiong KH, Mah LY, Leong CO. Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers. Apoptosis. 2013;18(12):1447–68.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Itoh N, Ornitz DM. Fibroblast growth factors: from molecular evolution to roles in development, metabolism and disease. J Biochem. 2011;149(2):121–30.

Article  CAS  PubMed  Google Scholar 

Itoh N, Ornitz DM. Evolution of the FGF and FGFR gene families. Trends Genet. 2004;20(11):563–9.

Article  CAS  PubMed  Google Scholar 

Kliewer SA, Mangelsdorf DJ. A dozen years of discovery: Insights into the physiology and pharmacology of FGF21. Cell Metab. 2019;29(2):246–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Razzaque MS. The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat Rev Endocrinol. 2009;5(11):611–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, et al. FGF-21 as a novel metabolic regulator. J Clin Invest. 2005;115(6):1627–35.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cariello M, Piglionica M, Gadaleta RM, Moschetta A. The enterokine fibroblast growth factor 15/19 in bile acid metabolism. Handb Exp Pharmacol. 2019;256:73–93.

Article  CAS  PubMed  Google Scholar 

Dieci MV, Arnedos M, Andre F, Soria JC. Fibroblast growth factor receptor inhibitors as a cancer treatment: from a biologic rationale to medical perspectives. Cancer Discov. 2013;3(3):264–79.

Article  CAS  PubMed  Google Scholar 

Krause DS, Van Etten RA. Tyrosine kinases as targets for cancer therapy. N Engl J Med. 2005;353(2):172–87.

Article  CAS  PubMed  Google Scholar 

Sarrazin S, Lamanna WC, Esko JD. Heparan sulfate proteoglycans. Cold Spring Harb Perspect Biol. 2011;3(7):a004952.

Article  PubMed  PubMed Central  Google Scholar 

Schlessinger J, Plotnikov AN, Ibrahimi OA, Eliseenkova AV, Yeh BK, Yayon A, et al. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 2000;6(3):743–50.

Article  CAS  PubMed  Google Scholar 

Ornitz DM, Itoh N. The fibroblast growth factor signaling pathway. Wiley Interdiscip Rev Dev Biol. 2015;4(3):215–66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ong SH, Guy GR, Hadari YR, Laks S, Gotoh N, Schlessinger J, et al. FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors. Mol Cell Biol. 2000;20(3):979–89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hadari YR, Gotoh N, Kouhara H, Lax I, Schlessinger J. Critical role for the docking-protein FRS2α in FGF receptor-mediated signal transduction pathways. Proc Natl Acad Sci U S A. 2001;98(15):8578–83.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belov AA, Mohammadi M. Molecular mechanisms of fibroblast growth factor signaling in physiology and pathology. Cold Spring Harb Perspect Biol. 2013;5(6):a015958.

Article  PubMed  PubMed Central  Google Scholar 

Eswarakumar VP, Monsonego OE, Pines M, Antonopoulou I, Morriss-Kay GM, Lonai P. The IIIc alternative of Fgfr2 is a positive regulator of bone formation. Development. 2002;129(16):3783–93.

Article  CAS  PubMed  Google Scholar 

Miraoui H, Marie PJ. Fibroblast growth factor receptor signaling crosstalk in skeletogenesis. Sci Signal. 2010;3(146):re9.

Article  PubMed  Google Scholar 

Minina E, Kreschel C, Naski MC, Ornitz DM, Vortkamp A. Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation. Dev Cell. 2002;3(3):439–49.

Article  CAS  PubMed  Google Scholar 

Katoh M, Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol Ther. 2006;5(9):1059–64.

Article  CAS  PubMed  Google Scholar 

Zhu X, Lee K, Asa SL, Ezzat S. Epigenetic silencing through DNA and histone methylation of fibroblast growth factor receptor 2 in neoplastic pituitary cells. Am J Pathol. 2007;170(5):1618–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sarabipour S, Hristova K. Mechanism of FGF receptor dimerization and activation. Nat Commun. 2016;7:10262.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Triantis V, Saeland E, Bijl N, Oude-Elferink RP, Jansen PL. Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1. Hepatology. 2010;52(2):656–66.

Article  CAS  PubMed  Google Scholar 

Kucińska M, Porębska N, Lampart A, Latko M, Knapik A, Zakrzewska M, et al. Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins. Cell Commun Signal. 2019;17(1):65.

Article  PubMed  PubMed Central  Google Scholar 

Porębska N, Latko M, Kucińska M, Zakrzewska M, Otlewski J, Opaliński Ł. Targeting cellular trafficking of fibroblast growth factor receptors as a strategy for selective cancer treatment. J Clin Med. 2018;8(1):7.

Article  PubMed  PubMed Central  Google Scholar 

Helsten T, Elkin S, Arthur E, Tomson BN, Carter J, Kurzrock R. The FGFR landscape in cancer: analysis of 4,853 tumors by next-generation sequencing. Clin Cancer Res. 2016;22(1):259–67.

Article  CAS  PubMed  Google Scholar 

Souza VC, Soares A, Maluf FC, Monteiro FSM, Gidekel R, Ardila-Salcedo J, et al. Clinicopathological characterization, FGFR alteration prevalence, and outcomes of locally advanced or metastatic urothelial cancer in Latin America (LACOG 1518). J Clin Oncol. 2022;40(16):E16549.

Article  Google Scholar 

Zhou Z, Liu ZC, Ou QX, Wu X, Wang XN, Shao Y, et al. Targeting FGFR in non-small cell lung cancer: implications from the landscape of clinically actionable aberrations of FGFR kinases. Cancer Biol Med. 2021;18(2):490.

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