Peppard PE, Young T, Barnet JH, Palta M, Hagen EW, Hla KM. Increased prevalence of sleep-disordered breathing in adults. Am J Epidemiol. 2013;177:1006–14.

Article  PubMed  PubMed Central  Google Scholar 

Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM, Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med. 2005;353:2034–41.

Article  CAS  PubMed  Google Scholar 

•• Aneni EC, Thorn SL, Feher A, Hong Chen J, Sinusas AJ, Yaggi HK, et al. The association between obstructive sleep apnea and abnormal 82rubidium cardiac PET perfusion myocardial flow reserve. JACC Cardiovasc Imag. 2023;16:856–8. Clinical study demonstrating an association between Severe OSA and abnormal MFR, measured by cardiac PET. The association was persistent even after controlling for possible confounders, and excluding those with perfusion abnormalities, known coronary artery disease and significant coronary artery calcification.

Schindler TH, Fearon WF, Pelletier-Galarneau M, et al. Myocardial perfusion PET for the detection and reporting of coronary microvascular dysfunction: A JACC: cardiovascular imaging expert panel statement. JACC Cardiovasc Imaging. 2023;16:536–48.

Article  PubMed  Google Scholar 

Højstrup S, Hansen KW, Talleruphuus U, et al. Myocardial flow reserve, an independent prognostic marker of all-cause mortality assessed by 82Rb PET myocardial perfusion imaging: a danish multicenter study. Circ Cardiovasc Imaging. 2023;16:e015184.

Article  PubMed  Google Scholar 

Srivaratharajah K, Coutinho T, deKemp R, et al. Reduced myocardial flow in heart failure patients with preserved ejection fraction. Circ Heart Fail. 2016;9:e002562.

Article  PubMed  Google Scholar 

Shah SJ, Lam CSP, Svedlund S, et al. Prevalence and correlates of coronary microvascular dysfunction in heart failure with preserved ejection fraction: PROMIS-HFpEF. Eur Heart J. 2018;39:3439–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hamilton GS, Meredith IT, Walker AM, Solin P. Obstructive sleep apnea leads to transient uncoupling of coronary blood flow and myocardial work in humans. Sleep. 2009;32:263–70.

Article  PubMed  PubMed Central  Google Scholar 

Kapur VK, Auckley DH, Chowdhuri S, Kuhlmann DC, Mehra R, Ramar K, et al. Clinical practice guideline for diagnostic testing for adult obstructive sleep apnea: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2017;13(3):479–504.

Article  PubMed  PubMed Central  Google Scholar 

Troester M, Quan SF, Berry RB, Abreu AR, Alzoubaidi M, Bandyopadhyay A, et al. The AASM manual for the scoring of sleep and associated events: rules, terminology and technical specifications, version 3.0. Darien, IL: American Academy of Sleep Medicine; 2023.

Google Scholar 

Pendharkar SR, Sharpe H, Rosychuk RJ, Laratta CR, Fong A, Duan QM, et al. Temporal and regional trends in obstructive sleep apnea using administrative health data in Alberta, Canada. Ann Am Thorac Soc. 2023;20:433–9.

Article  PubMed  Google Scholar 

Fietze I, Laharnar N, Obst A, et al. Prevalence and association analysis of obstructive sleep apnea with gender and age differences – Results of SHIP-Trend. J Sleep Res. 2019;28:e12770.

Article  PubMed  Google Scholar 

Huang T, Lin BM, Redline S, Curhan GC, Hu FB, Tworoger SS. Type of menopause, age at menopause, and risk of developing obstructive sleep apnea in postmenopausal women. Am J Epidemiol. 2018;187:1370–9.

Article  PubMed  PubMed Central  Google Scholar 

Krüger M, Obst A, Ittermann T, et al. Menopause is associated with obstructive sleep apnea in a population-based sample from Mecklenburg-Western Pomerania, Germany. J Clin Med. 2023;12:2101.

Article  PubMed  PubMed Central  Google Scholar 

Pedrosa RP, Drager LF, Gonzaga CC, et al. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension. 2011;58:811–7.

Article  CAS  PubMed  Google Scholar 

Narkiewicz K, Somers VK. Obstructive sleep apnea as a cause of neurogenic hypertension. Curr Hypertens Rep. 1999;1:268–73.

Article  CAS  PubMed  Google Scholar 

Javaheri S, Barbe F, Campos-Rodriguez F, et al. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. J Am Coll Cardiol. 2017;69:841–58.

Article  PubMed  PubMed Central  Google Scholar 

Drager LF, Polotsky VY, O’Donnell CP, Cravo SL, Lorenzi-Filho G, Machado BH. Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea. American Journal of Physiology-Heart and Circulatory Physiology. 2015;309:H1101–11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdullah A, Eigbire G, Salama A, Wahab A, Nadkarni N, Alweis R. Relation of obstructive sleep apnea to risk of hospitalization in patients with heart failure and preserved ejection fraction from the national inpatient sample. Am J Cardiol. 2018;122:612–5.

Article  PubMed  Google Scholar 

Connolly JE, Genuardi MV, Mora JI, Prenner SB. Heart failure with preserved ejection fraction risk is associated with prevalence and severity of obstructive sleep apnea. J Clin Sleep Med. 2023. https://doi.org/10.5664/jcsm.10876.

Article  Google Scholar 

Wang N, Li S-B, Zhao L-S, Li H-Y, Li Z-J, Shi Q-W, et al. Relationship between obstructive sleep apnea and coronary microcirculatory function among patients with cardiac syndrome X. Coron Artery Dis. 2014;25:35–9.

Article  PubMed  Google Scholar 

Ooi EL, Rajendran S, Munawar DA, Hnin K, Mahadavan G, Pati P, et al. The Association of obstructive sleep apnea in ischemia with no obstructive coronary artery disease – a pilot study. Curr Probl Cardiol. 2023;48:101111.

Article  PubMed  Google Scholar 

Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine clinical practice guideline. J Clin Sleep Med. 2019;15(2):335–43.

Article  PubMed  PubMed Central  Google Scholar 

Weaver TE, Sawyer AM. Adherence to continuous positive airway pressure treatment for obstructive sleep apnea: implications for future interventions. Indian J Med Res. 2010;131:245–58.

PubMed  Google Scholar 

Hu X, Fan J, Chen S, Yin Y, Zrenner B. The Role of Continuous Positive Airway Pressure in Blood Pressure Control for Patients With Obstructive Sleep Apnea and Hypertension: A Meta-Analysis of Randomized Controlled Trials. The Journal of Clinical Hypertension. 2015;17:215–22.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Qureshi WT, Nasir UB, Alqalyoobi S, O’Neal WT, Mawri S, Sabbagh S, et al. Meta-analysis of continuous positive airway pressure as a therapy of atrial fibrillation in obstructive sleep apnea. Am J Cardiol. 2015;116:1767–73.

Article  PubMed  Google Scholar 

Deng F, Raza A, Guo J. Treating obstructive sleep apnea with continuous positive airway pressure reduces risk of recurrent atrial fibrillation after catheter ablation: a meta-analysis. Sleep Med. 2018;46:5–11.

Article  PubMed  Google Scholar 

Tadic M, Gherbesi E, Faggiano A, Sala C, Carugo S, Cuspidi C. The impact of continuous positive airway pressure on cardiac mechanics: Findings from a meta-analysis of echocardiographic studies. J Clin Hypertens (Greenwich). 2022;24:795–803.

Article  PubMed  Google Scholar 

Kasai T, Narui K, Dohi T, Yanagisawa N, Ishiwata S, Ohno M, et al. rognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest. 2008;133:690–6.

Article  PubMed  Google Scholar 

Khayat R, Jarjoura D, Porter K, Sow A, Wannemacher J, Dohar R, et al. Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J. 2015;36:1463–9.

Article  PubMed  PubMed Central  Google Scholar 

McEvoy RD, Antic NA, Heeley E, et al. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. 2016;375:919–31.

Article  PubMed  Google Scholar 

Sánchez-de-la-Torre M, Sánchez-de-la-Torre A, Bertran S, et al. Effect of obstructive sleep apnoea and its treatment with continuous positive airway pressure on the prevalence of cardiovascular events in patients with acute coronary syndrome (ISAACC study): a randomised controlled trial. Lancet Respir Med. 2020;8:359–67.

Article  PubMed  Google Scholar 

Peker Y, Glantz H, Eulenburg C, Wegscheider K, Herlitz J, Thunström E. Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea. The RICCADSA randomized controlled trial. Am J Respir Crit Care Med. 2016;194:613–20.

Article  CAS  PubMed  Google Scholar 

Pack AI, Magalang UJ, Singh B, Kuna ST, Keenan BT, Maislin G. Randomized clinical trials of cardiovascular disease in obstructive sleep apnea: understanding and overcoming bias. Sleep. 2020;44:zsaa229.

Article  PubMed Central  Google Scholar 

Sánchez-de-la-Torre M, Gracia-Lavedan E, Benitez ID, et al. Adherence to CPAP treatment and the risk of recurrent cardiovascular events: a meta-analysis. JAMA. 2023;330:1255–65.

Article  PubMed  PubMed Central  Google Scholar 

Duncker DJ, Koller A, Merkus D, Canty JM. Regulation of coronary blood flow in health and ischemic heart disease. Prog Cardiovasc Dis. 2015;57:409–22.

Article  PubMed  Google Scholar 

Vijayan S, Barmby DS, Pearson IR, Davies AG, Wheatcroft SB, Sivananthan M. Assessing coronary blood flow physiology in the cardiac catheterisation laboratory. Curr Cardiol Rev. 2017;13:232–43.

Article  PubMed  PubMed Central  Google Scholar 

Goodwill AG, Dick GM, Kiel AM, Tune JD. Regulation of coronary blood flow. Compr Physiol. 2017;7:321–82.

Article  PubMed  PubMed Central