Cooper, D. K. C. & Pierson, R. N. Milestones on the path to clinical pig organ xenotransplantation. Am. J. Transpl. 23, 326–335 (2023).

Article  Google Scholar 

Wolbrom, D. H., Kim, J. I. & Griesemer, A. The road to xenotransplantation. Curr. Opin. Organ Transpl. 28, 65–70 (2023).

Article  Google Scholar 

Ekser, B., Rigotti, P., Gridelli, B. & Cooper, D. K. C. Xenotransplantation of solid organs in the pig-to-primate model. Transpl. Immunol. 21, 87–92 (2009).

Article  PubMed  Google Scholar 

Pintore, L. et al. Clinicopathological findings in non-human primate recipients of porcine renal xenografts: quantitative and qualitative evaluation of proteinuria. Xenotransplantation 20, 449–457 (2013).

Article  PubMed  Google Scholar 

Mohiuddin, M. M. et al. Graft dysfunction in compassionate use of genetically engineered pig-to-human cardiac xenotransplantation: a case report. Lancet 402, 397–410 (2023).

Article  PubMed  Google Scholar 

Moazami, N. et al. Pig-to-human heart xenotransplantation in two recently deceased human recipients. Nat. Med. 29, 1989–1997 (2023).

Article  CAS  PubMed  Google Scholar 

Zhou, W. et al. Longitudinal multi-omics of host-microbe dynamics in prediabetes. Nature 569, 663–671 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garrett-Bakelman, F. E. et al. The NASA Twins Study: a multidimensional analysis of a year-long human spaceflight. Science 364, eaau8650 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piening, B. D. et al. Integrative personal omics profiles during periods of weight gain and loss. Cell Syst. 6, 157–170 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schüssler-Fiorenza Rose, S. M. et al. A longitudinal big data approach for precision health. Nat. Med. 25, 792–804 (2019).

Article  PubMed  Google Scholar 

Ghaemi, M. S. et al. Multiomics modeling of the immunome, transcriptome, microbiome, proteome and metabolome adaptations during human pregnancy. Bioinformatics 35, 95–103 (2019).

Article  CAS  PubMed  Google Scholar 

Shaked, A. et al. An ectopically expressed serum miRNA signature is prognostic, diagnostic, and biologically related to liver allograft rejection. Hepatology 65, 269–280 (2017).

Article  CAS  PubMed  Google Scholar 

Piening, B. D. et al. Whole transcriptome profiling of prospective endomyocardial biopsies reveals prognostic and diagnostic signatures of cardiac allograft rejection. J. Heart Lung Transpl. 41, 840–848 (2022).

Article  Google Scholar 

Long, X., Yuan, X. & Du, J. Single-cell and spatial transcriptomics: advances in heart development and disease applications. Comput Struct. Biotechnol. J. 21, 2717–2731 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ospina, O., Soupir, A. & Fridley, B. L. A primer on preprocessing, visualization, clustering, and phenotyping of barcode-based spatial transcriptomics data. Methods Mol. Biol. 2629, 115–140 (2023).

Article  CAS  PubMed  Google Scholar 

Finn, E. H. & Misteli, T. Molecular basis and biological function of variability in spatial genome organization. Science 365, eaaw9498 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martin, M. D. & Badovinac, V. P. Defining memory CD8 T cell. Front Immunol. 9, 2692 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Golubovskaya, V. & Wu, L. Different subsets of T cells, memory, effector functions, and CAR-T immunotherapy. Cancers 8, 36 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brinas, F., Danger, R. & Brouard, S. TCL1A, B cell regulation and tolerance in renal transplantation. Cells 10, 1367 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Andrijevic, D. et al. Cellular recovery after prolonged warm ischaemia of the whole body. Nature 608, 405–412 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sathaliyawala, T. et al. Distribution and compartmentalization of human circulating and tissue-resident memory T cell subsets. Immunity 38, 187–197 (2013).

Article  CAS  PubMed  Google Scholar 

Love, M. I., Huber, W. & Anders, S. Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biol. 15, 550 (2014).

Article  PubMed  PubMed Central  Google Scholar 

Roh, J. S. & Sohn, D. H. Damage-associated molecular patterns in inflammatory diseases. Immune Netw. 18, e27 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Byrne, G. W., Du, Z., Sun, Z., Asmann, Y. W. & McGregor, C. G. A. Changes in cardiac gene expression after pig-to-primate orthotopic xenotransplantation. Xenotransplantation 18, 14–27 (2011).

Article  PubMed  PubMed Central  Google Scholar 

Linna-Kuosmanen, S. et al. Cardiovascular disease causes proinflammatory microvascular changes in the human right atrium. Preprint at bioRxiv https://doi.org/10.1101/2021.06.23.449672 (2022).

Shimizu, Y. et al. Impact of lymphangiogenesis on cardiac remodeling after ischemia and reperfusion injury. J. Am. Heart Assoc. 7, e009565 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Giarraputo, A. et al. Banff human organ transplant consensus gene panel for the detection of antibody mediated rejection in heart allograft biopsies. Transpl. Int. 36, 11710 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Florens, N. et al. Interleukin-33 mediates cardiomyopathy after acute kidney injury by signaling to cardiomyocytes. Circulation 147, 746–758 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mehrotra, P. et al. IL-17 mediates neutrophil infiltration and renal fibrosis following recovery from ischemia reperfusion: compensatory role of natural killer cells in athymic rats. Am. J. Physiol. Ren. Physiol. 312, F385–F397 (2017).

Article  CAS  Google Scholar 

Baban, B., Liu, J. Y. & Mozaffari, M. S. SGK-1 regulates inflammation and cell death in the ischemic-reperfused heart: pressure-related effects. Am. J. Hypertens. 27, 846–856 (2014).

Article  CAS  Google Scholar 

Azad, A. K., Chakrabarti, S., Xu, Z., Davidge, S. T. & Fu, Y. Coiled-coil domain containing 3 (CCDC3) represses tumor necrosis factor-α/nuclear factor κB-induced endothelial inflammation. Cell Signal 26, 2793–2800 (2014).

Article  CAS  PubMed  Google Scholar 

Flinn, M. A. et al. Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes. Front. Cardiovasc. Med. 10, 1142612 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Banaszkiewicz, M., Olejnik, A., Krzywonos-Zawadzka, A., Hałucha, K. & Bil-Lula, I. Expression of atrial‑fetal light chains in cultured human cardiomyocytes after chemical ischemia‑reperfusion injury. Mol. Med. Rep. 24, 770 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byrne, G. W. & McGregor, C. G. A. Cardiac xenotransplantation: progress and challenges. Curr. Opin. Organ Transpl. 17, 148–154 (2012).

Article  CAS  Google Scholar 

Koritzinsky, E. H., Tsuda, H. & Fairchild, R. L. Endogenous memory T cells with donor-reactivity: early post-transplant mediators of acute graft injury in unsensitized recipients. Transpl. Int. 34, 1360–1373 (2021).

Article  CAS  PubMed  Google Scholar 

Pearl, J. P. et al. Immunocompetent T-cells with a memory-like phenotype are the dominant cell type following antibody-mediated T-cell depletion. Am. J. Transpl. 5, 465–474 (2005).

Article  CAS  Google Scholar 

White, J. T., Cross, E. W. & Kedl, R. M. Antigen-inexperienced memory CD8+ T cells: where they come from and why we need them. Nat. Rev. Immunol. 17, 391–400 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakamura, K., Kageyama, S. & Kupiec-Weglinski, J. W. Innate immunity in ischemia-reperfusion injury and graft rejection. Curr. Opin. Organ Transpl. 24, 687–693 (2019).

Article  CAS  Google Scholar 

El-Sawy, T., Miura, M. & Fairchild, R. Early T cell response to allografts occurring prior to alloantigen priming up-regulates innate-mediated inflammation and graft necrosis. Am. J. Pathol. 165, 147–157 (2004).

Article