Steiner TJ, Stovner LJ, Vos T, Jensen R, Katsarava Z. Migraine is first cause of disability in under 50s: will health politicians now take notice? J Headache Pain. 2018;19(1):17. https://doi.org/10.1186/s10194-018-0846-2.

Article  PubMed  PubMed Central  Google Scholar 

Becker WJ, Findlay T, Moga C, Scott NA, Harstall C, Taenzer P. Guideline for primary care management of headache in adults. Can Fam Physician. 2015;61(8):670–9.

PubMed  PubMed Central  Google Scholar 

Marmura MJ, Silberstein SD, Schwedt TJ. The acute treatment of migraine in adults: the american headache society evidence assessment of migraine pharmacotherapies. Headache. 2015;55(1):3–20. https://doi.org/10.1111/head.12499.

Article  PubMed  Google Scholar 

Bigal ME, Lipton RB. The epidemiology, burden, and comorbidities of migraine. Neurol Clin. 2009;27(2):321–34. https://doi.org/10.1016/j.ncl.2008.11.011.

Article  PubMed  Google Scholar 

Buse DC, Manack A, Serrano D, Turkel C, Lipton RB. Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. 2010;81(4):428–32. https://doi.org/10.1136/jnnp.2009.192492.

Article  CAS  PubMed  Google Scholar 

Scher AI, Bigal ME, Lipton RB. Comorbidity of migraine. Curr Opin Neurol. 2005;18(3):305–10. https://doi.org/10.1097/01.wco.0000169750.52406.a2.

Article  PubMed  Google Scholar 

Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, et al. World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med. 2020;54(24):1451–62. https://doi.org/10.1136/bjsports-2020-102955.

Article  PubMed  Google Scholar 

Daenen L, Varkey E, Kellmann M, Nijs J. Exercise, not to exercise, or how to exercise in patients with chronic pain? Applying science to practice. Clin J Pain. 2015;31(2):108–14. https://doi.org/10.1097/ajp.0000000000000099.

Article  PubMed  Google Scholar 

Häuser W, Klose P, Langhorst J, Moradi B, Steinbach M, Schiltenwolf M, et al. Efficacy of different types of aerobic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomised controlled trials. Arthritis Res Ther. 2010;12(3):R79. https://doi.org/10.1186/ar3002.

Article  PubMed  PubMed Central  Google Scholar 

Dinler M, Diracoglu D, Kasikcioglu E, Sayli O, Akin A, Aksoy C, et al. Effect of aerobic exercise training on oxygen uptake and kinetics in patients with fibromyalgia. Rheumatol Int. 2009;30(2):281–4. https://doi.org/10.1007/s00296-009-1126-x.

Article  CAS  PubMed  Google Scholar 

Hoffman MD, Shepanski MA, Mackenzie SP, Clifford PS. Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic low back pain. J Rehabil Res Dev. 2005;42(2):183–90. https://doi.org/10.1682/jrrd.2004.06.0065.

Article  PubMed  Google Scholar 

Song TJ, Chu MK. Exercise in Treatment of Migraine Including Chronic Migraine. Curr Pain Headache Rep. 2021;25(3):14. https://doi.org/10.1007/s11916-020-00929-w.

Article  PubMed  Google Scholar 

Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: An R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022;18(2): e1230. https://doi.org/10.1002/cl2.1230.

Article  PubMed  PubMed Central  Google Scholar 

Oliveira AB, Ribeiro RT, Mello MT, Tufik S, Peres MFP. Anandamide Is Related to Clinical and Cardiorespiratory Benefits of Aerobic Exercise Training in Migraine Patients: A Randomized Controlled Clinical Trial. Cannabis Cannabinoid Res. 2019;4(4):275–84. https://doi.org/10.1089/can.2018.0057.

Article  PubMed  PubMed Central  Google Scholar 

Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, Tugwell P. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Accessed 2 Feb 2024.

Higgins JPT TJ, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.4 (updated August 2023). Cochrane. 2023.

Bond DS, Thomas JG, Lipton RB, Roth J, Pavlovic JM, Rathier L, et al. Behavioral Weight Loss Intervention for Migraine: A Randomized Controlled Trial. Obesity (Silver Spring). 2018;26(1):81–7. https://doi.org/10.1002/oby.22069.

Article  PubMed  Google Scholar 

Darabaneanu S, Overath CH, Rubin D, Lüthje S, Sye W, Niederberger U, et al. Aerobic exercise as a therapy option for migraine: a pilot study. Int J Sports Med. 2011;32(6):455–60. https://doi.org/10.1055/s-0030-1269928.

Article  CAS  PubMed  Google Scholar 

Dittrich SM, Günther V, Franz G, Burtscher M, Holzner B, Kopp M. Aerobic exercise with relaxation: influence on pain and psychological well-being in female migraine patients. Clin J Sport Med. 2008;18(4):363–5. https://doi.org/10.1097/JSM.0b013e31817efac9.

Article  PubMed  Google Scholar 

•• Hanssen H, Minghetti A, Magon S, Rossmeissl A, Rasenack M, Papadopoulou A, et al. Effects of different endurance exercise modalities on migraine days and cerebrovascular health in episodic migraineurs: A randomized controlled trial. Scand J Med Sci Sports. 2018;28(3):1103–12. https://doi.org/10.1111/sms.13023. This was the first clinical trial to observe the effect of high-intensity aerobic exercise on the prevention of migraine.

Article  CAS  PubMed  Google Scholar 

Krøll LS, Hammarlund CS, Linde M, Gard G, Jensen RH. The effects of aerobic exercise for persons with migraine and co-existing tension-type headache and neck pain. A randomized, controlled, clinical trial. Cephalalgia. 2018;38(12):1805–16. https://doi.org/10.1177/0333102417752119.

Article  PubMed  Google Scholar 

Narin SO, Pinar L, Erbas D, Oztürk V, Idiman F. The effects of exercise and exercise-related changes in blood nitric oxide level on migraine headache. Clin Rehabil. 2003;17(6):624–30. https://doi.org/10.1191/0269215503cr657oa.

Article  PubMed  Google Scholar 

Santiago MD, Carvalho Dde S, Gabbai AA, Pinto MM, Moutran AR, Villa TR. Amitriptyline and aerobic exercise or amitriptyline alone in the treatment of chronic migraine: a randomized comparative study. Arq Neuropsiquiatr. 2014;72(11):851–5. https://doi.org/10.1590/0004-282x20140148.

Article  PubMed  Google Scholar 

Varkey E, Cider A, Carlsson J, Linde M. Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls. Cephalalgia. 2011;31(14):1428–38. https://doi.org/10.1177/0333102411419681.

Article  PubMed  PubMed Central  Google Scholar 

Amin FM, Aristeidou S, Baraldi C, Czapinska-Ciepiela EK, Ariadni DD, Di Lenola D, et al. The association between migraine and physical exercise. J Headache Pain. 2018;19(1):83. https://doi.org/10.1186/s10194-018-0902-y.

Article  PubMed  PubMed Central  Google Scholar 

Lemmens J, De Pauw J, Van Soom T, Michiels S, Versijpt J, van Breda E, et al. The effect of aerobic exercise on the number of migraine days, duration and pain intensity in migraine: a systematic literature review and meta-analysis. J Headache Pain. 2019;20(1):16. https://doi.org/10.1186/s10194-019-0961-8.

Article  PubMed  PubMed Central  Google Scholar 

Broman-Fulks JJ, Storey KM. Evaluation of a brief aerobic exercise intervention for high anxiety sensitivity. Anxiety Stress Coping. 2008;21(2):117–28. https://doi.org/10.1080/10615800701762675.

Article  PubMed  Google Scholar 

Broocks A, Bandelow B, Pekrun G, George A, Meyer T, Bartmann U, et al. Comparison of aerobic exercise, clomipramine, and placebo in the treatment of panic disorder. Am J Psychiatry. 1998;155(5):603–9. https://doi.org/10.1176/ajp.155.5.603.

Article  CAS  PubMed  Google Scholar 

Carmeli E, Barak S, Morad M, Kodesh E. Physical exercises can reduce anxiety and improve quality of life among adults with intellectual disability : original research article. International SportMed Journal. 2009;10(2):77–85. https://doi.org/10.10520/EJC48373.

Article  Google Scholar 

Goldin P, Ziv M, Jazaieri H, Gross JJ. Randomized controlled trial of mindfulness-based stress reduction versus aerobic exercise: effects on the self-referential brain network in social anxiety disorder. Front Hum Neurosci. 2012;6:295. https://doi.org/10.3389/fnhum.2012.00295.

Article  PubMed  PubMed Central  Google Scholar 

Kim SH, Schneider SM, Bevans M, Kravitz L, Mermier C, Qualls C, et al. PTSD symptom reduction with mindfulness-based stretching and deep breathing exercise: randomized controlled clinical trial of efficacy. J Clin Endocrinol Metab. 2013;98(7):2984–92. https://doi.org/10.1210/jc.2012-3742.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Oldridge N, Guyatt G, Jones N, Crowe J, Singer J, Feeny D, et al. Effects on quality of life with comprehensive rehabilitation after acute myocardial infarction. Am J Cardiol. 1991;67(13):1084–9. https://doi.org/10.1016/0002-9149(91)90870-q.

Article  CAS  PubMed  Google Scholar 

Smits JA, Berry AC, Rosenfield D, Powers MB, Behar E, Otto MW. Reducing anxiety sensitivity with exercise. Depress Anxiety. 2008;25(8):689–99. https://doi.org/10.1002/da.20411.

Article  PubMed  Google Scholar 

Villaverde Gutiérrez C, Torres Luque G, Ábalos Medina GM, Argente del Castillo MJ, Guisado IM, Guisado Barrilao R, et al. Influence of exercise on mood in postmenopausal women. J Clin Nurs. 2012;21(7–8):923–8. https://doi.org/10.1111/j.1365-2702.2011.03972.x.

Article  PubMed  Google Scholar 

Wedekind D, Broocks A, Weiss N, Engel K, Neubert K, Bandelow B. A randomized, controlled trial of aerobic exercise in combination with paroxetine in the treatment of panic disorder. World J Biol Psychiatry. 2010;11(7):904–13. https://doi.org/10.3109/15622975.2010.489620.

Article  PubMed  Google Scholar 

Hovland A, Nordhus IH, Sjøbø T, Gjestad BA, Birknes B, Martinsen EW, et al. Comparing physical exercise in groups to group cognitive behaviour therapy for the treatment of panic disorder in a randomized controlled trial. Behav Cogn Psychother. 2013;41(4):408–32.