Colorectal Russell body lesions are exceedingly rare with only four cases described in literature to date.1 We report here a case of Russell body typhilitis in a middle-aged woman on neoadjuvant chemotherapy for breast carcinoma.

The first case of Russell body-containing lesion of the gastrointestinal tract (GI) was documented in the stomach, in 1998. Since then, around 40 cases have been reported, most of which involve the upper GI tract.1 They are most frequently identified in the stomach as Russell body gastritis and have been associated with Helicobacter pylori infection.2 Some reports have linked them to immunosuppressive state and occasional cases have been found inadvertently in adjacent mucosa in gastric carcinoma. The patient age of Russell body lesions ranged from 24 to 88 years of age with a male-to-female ratio of 1.6:1.3

The first case of Russell body colitis was reported in the year 1999, in a 53-year-old woman.2 Out of the four cases described, two presented as colorectal polyps (one patient as tubulovillous adenoma with high-grade dysplasia, and the other as Russell body inflammatory polyp and had associated severe diverticulosis in the colonic segments).2 4 The third case showed multiple caecal erosions likely to be associated with non-steroidal anti-inflammatory drugs.1 The last case was documented in an immunocompromised patient, where colonoscopy was normal (table 1).5

Reported cases of Russell body inflammatory lesions of the colorectum

Here, we present a case of a …