Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920–926 (1993).
Article CAS PubMed Google Scholar
Huey, D. J., Hu, J. C. & Athanasiou, K. A. Unlike bone, cartilage regeneration remains elusive. Science 338, 917–921 (2012).
Article CAS PubMed PubMed Central Google Scholar
Matthews, L. S., Sonstegard, D. A. & Henke, J. A. Load bearing characteristics of the patello-femoral joint. Acta Orthop. Scand. 48, 511–516 (1977).
Article CAS PubMed Google Scholar
Kellathur, S. N. & Lou, H.-X. Cell and tissue therapy regulation: worldwide status and harmonization. Biologicals 40, 222–224 (2012).
Nordberg, R. C., Otarola, G. A., Wang, D., Hu, J. C. & Athanasiou, K. A. Navigating regulatory pathways for translation of biologic cartilage repair products. Sci. Transl. Med. 14, eabp8163 (2022).
Article CAS PubMed PubMed Central Google Scholar
US Food and Drug Administration. Expedited programs for regenerative medicine therapies for serious conditions. fda.gov https://www.fda.gov/regulatory-information/search-fda-guidance-documents/expedited-programs-regenerative-medicine-therapies-serious-conditions (2019).
Muthu, S. et al. Failure of cartilage regeneration: emerging hypotheses and related therapeutic strategies. Nat. Rev. Rheumatol. 19, 403–416 (2023).
Article CAS PubMed Google Scholar
Sun, H. B. Mechanical loading, cartilage degradation, and arthritis. Ann. N. Y. Acad. Sci. 1211, 37–50 (2010).
Article CAS PubMed Google Scholar
Torzilli, P. A., Grigiene, R., Borrelli, J. & Helfet, D. L. Effect of impact load on articular cartilage: cell metabolism and viability, and matrix water content. J. Biomech. Eng. 121, 433–441 (1999).
Article CAS PubMed Google Scholar
Long, H. et al. Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the Global Burden of Disease study 2019. Arthritis Rheumatol. 74, 1172–1183 (2022).
Article PubMed PubMed Central Google Scholar
Almutairi, K., Nossent, J., Preen, D., Keen, H. & Inderjeeth, C. The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review. Rheumatol. Int. 41, 863–877 (2021).
Andriacchi, T. P. & Favre, J. The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis. Curr. Rheumatol. Rep. 16, 463 (2014).
Bullock, J. et al. Rheumatoid arthritis: a brief overview of the treatment. Med. Princ. Pract. 27, 501–507 (2018).
Article PubMed PubMed Central Google Scholar
Ruiz, D. J. et al. The direct and indirect costs to society of treatment for end-stage knee osteoarthritis. J. Bone Jt Surg. Am. 95, 1473–1480 (2013).
Birnbaum, H. et al. Societal cost of rheumatoid arthritis patients in the US. Curr. Med. Res. Opin. 26, 77–90 (2010).
Torio, C. & Moore, B. National inpatient hospital costs: the most expensive conditions by payer, 2013. in Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. PMID: 27359025 (2016).
Takahashi, T. et al. Commercialization of regenerative-medicine therapies. Nat. Rev. Bioeng. 1, 906–929 (2023).
Lee, D. H., Kim, S. J., Kim, S. A. & Ju, G. Past, present, and future of cartilage restoration: from localized defect to arthritis. Knee Surg. Relat. Res. 34, 1 (2022).
Article PubMed PubMed Central Google Scholar
Kwon, H. et al. Surgical and tissue engineering strategies for articular cartilage and meniscus repair. Nat. Rev. Rheumatol. 15, 550–570 (2019).
Article PubMed PubMed Central Google Scholar
Murray, I. R. et al. Regulatory and ethical aspects of orthobiologic therapies. Orthop. J. Sports Med. 10, 23259671221101624 (2022).
European Medicines Agency. Spherox. em.europa.eu https://www.ema.europa.eu/en/medicines/human/EPAR/spherox (2023).
National Institute for Health and Care Excellence. Autologous chondrocyte implantation using chondrosphere for treating symptomatic articular cartilage defects of the knee. nice.org.uk https://www.nice.org.uk/guidance/ta508/resources/autologous-chondrocyte-implantation-using-chondrosphere-for-treating-symptomatic-articular-cartilage-defects-of-the-knee-pdf-82606726260421 (2018).
Jiang, S. et al. Clinical application status of articular cartilage regeneration techniques: tissue-engineered cartilage brings new hope. Stem Cell Int. 2020, 5690252 (2020).
National Institute for Health and Care Research. NOVOCART 3D for articular cartilage defects of the knee. io.nihr.ac.uk https://www.io.nihr.ac.uk/wp-content/uploads/2022/01/13181-Autologous-Chondrocyte-Implant-for-Articular-Cartilage-Defects-V1.0-SEP2019-NON-CONF.pdf (2019).
US Food and Drug Administration. Approved cellular and gene therapy products. fda.gov https://www.fda.gov/vaccines-blood-biologics/cellular-gene-therapy-products/approved-cellular-and-gene-therapy-products (2024).
Pharmaceuticals and Medical Devices Agency. Review reports: regenerative medical products. pmda.go.jp https://www.pmda.go.jp/english/review-services/reviews/approved-information/0004.html (2023).
Ministry of Food and Drug Safety. 2022 Drug approval report. mfds.go.kr https://www.mfds.go.kr/eng/brd/m_19/down.do?brd_id=eng0004&seq=70438&data_tp=A&file_seq=1 (2023).
World Health Organization. Ageing and health. who.int https://who.int/news-room/fact-sheets/detail/ageing-and-health (2022).
Bielajew, B. J. et al. Knee orthopedics as a template for the temporomandibular joint. Cell Rep. Med. 2, 100241 (2021).
Article PubMed PubMed Central Google Scholar
Manchikanti, L. et al. Prevalence of facet joint pain in chronic spinal pain of cervical, thoracic, and lumbar regions. BMC Musculoskelet. Disord. 5, 15 (2004).
Article PubMed PubMed Central Google Scholar
Lawrence, R. C. et al. Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 58, 26–35 (2008).
Article PubMed PubMed Central Google Scholar
Evenbratt, H. et al. Insights into the present and future of cartilage regeneration and joint repair. Cell Regen. 11, 3 (2022).
Article CAS PubMed PubMed Central Google Scholar
LaPrade, R. F. & Botker, J. C. Donor-site morbidity after osteochondral autograft transfer procedures. Arthroscopy 20, e69–e73 (2004).
Li, Y., Wei, X., Zhou, J. & Wei, L. The age-related changes in cartilage and osteoarthritis. Biomed. Res. Int. 2013, 916530 (2013).
PubMed PubMed Central Google Scholar
Darling, E. M. & Athanasiou, K. A. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J. Orthop. Res. 23, 425–432 (2005).
Article CAS PubMed Google Scholar
US Department of Health & Human Services. Points to consider in the characterization of cell lines used to produce biologicals. fda.gov https://www.fda.gov/media/76255/download (1993).
Park, Y.-B., Ha, C.-W., Lee, C.-H., Yoon, Y. C. & Park, Y.-G. Cartilage regeneration in osteoarthritic patients by a composite of allogeneic umbilical cord blood-derived mesenchymal stem cells and hyaluronate hydrogel: results from a clinical trial for safety and proof-of-concept with 7 years of extended follow-up. Stem Cell Transl. Med. 6, 613–621 (2017).
Gille, J., Behrens, P., Schulz, A. P., Oheim, R. & Kienast, B. Matrix-associated autologous chondrocyte implantation. Cartilage 7, 309–315 (2016).
Article PubMed PubMed Central Google Scholar
Hoburg, A. et al. Safety and efficacy of matrix-associated autologous chondrocyte implantation with spheroids for patellofemoral or tibiofemoral defects: a 5-year follow-up of a phase 2, dose-confirmation trial. Orthop. J. Sports Med. 10, 232596712110533 (2022).
Thorp, H. et al. Trends in articular cartilage tissue engineering: 3D mesenchymal stem cell sheets as candidates for engineered hyaline-like cartilage. Cells 10, 643 (2021).
Article CAS PubMed PubMed Central Google Scholar
Vonk, L. A., De Windt, T. S., Slaper-Cortenbach, I. C. M. & Saris, D. B. F. Autologous, allogeneic, induced pluripotent stem cell or a combination stem cell therapy? Where are we headed in cartilage repair and why: a concise review. Stem Cell Res. Ther. 6, 94 (2015).
Article PubMed PubMed Central Google Scholar
Lin, Z. et al. Gene expression profiles of human chondrocytes during passaged monolayer cultivation. J. Orthop. Res. 26, 1230–1237 (2008).
Article CAS PubMed Google Scholar
Cavalli, E. et al. Characterization of polydactyly chondrocytes and their use in cartilage engineering. Sci. Rep. 9, 4275 (2019).
Article PubMed PubMed Central Google Scholar
Tsvetkova, A. V. et al. Chondrogeneic potential of MSC from different sources in spheroid culture. Bull. Exp. Biol. Med. 170, 528–536 (2021).
Article CAS PubMed Google Scholar
Mohamed-Ahmed, S. et al. Adipose-derived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res. Ther. 9, 168 (2018).
Article CAS PubMed PubMed Central Google Scholar
Pievani, A. et al. Comparative analysis of multilineage properties of mesenchymal stromal cells derived from fetal sources shows an advantage of mesenchymal stromal cells isolated from cord blood in chondrogenic differentiation potential. Cytotherapy 16, 893–905 (2014).
留言 (0)