The LRRK2-G2019S mutation attenuates repair of brain injury partially by reducing the release of osteopontin-containing monocytic exosome-like vesicles
Keywords
LRRK2 G2019S
Neurodegenerative diseases
Brain injury
Repair
Monocyte
Osteopontin
Exosome-like vesicles
AbbreviationsLRRK2
leucine-rich repeat kinase 2
MAP2
microtubule-associated protein 2
a-cas-1/11
activated caspase-1/11
N-GSDMD
N-terminal fragment of gasdermin D
NLRP3
NLR family pyrin domain containing 3
BMDMs
bone marrow-derived macrophages
ATP
adenosine triphosphate
WT/GS exo
exosomes obtained from injured WT/GS brains
aOPN
OPN-blocking antibodies.
Data availability
All study data are included in the main text and Supporting Information. Gene expression data are available in the Gene Expression Omnibus (GEO) (GSE215277).
© 2024 The Authors. Published by Elsevier Inc.
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