Levy A, Mercier O, Le Péchoux C. Indications and parameters around postoperative Radiation Therapy for Lung Cancer. J Clin Oncol. 2022;40:556–66. https://doi.org/10.1200/JCO.21.01774.

Article  CAS  PubMed  Google Scholar 

Süveg K, Le Pechoux C, Faivre-Finn C, Putora PM, de Ruysscher D, Widder J, et al. Role of postoperative Radiotherapy in the management for Resected NSCLC - decision Criteria in Clinical Routine pre- and Post-LungART. Clin Lung Cancer. 2021;22:579–86. https://doi.org/10.1016/j.cllc.2021.08.007.

Article  CAS  PubMed  Google Scholar 

Faivre-Finn C, Edwards JG, Hatton M. Postoperative Radiation Therapy should not be used for the therapy of stage III-N2 NSCLC. J Thorac Oncol. 2022;17:197–9. https://doi.org/10.1016/j.jtho.2021.09.005.

Article  PubMed  Google Scholar 

Harris JP, Fujimoto DK, Nagasaka M, Ku E, Harada G, Keshava H, et al. Controversies in Lung Cancer: heterogeneity in treatment recommendations for stage III NSCLC according to Disease Burden and oncogenic driver alterations. Clin Lung Cancer. 2022;23:333–44. https://doi.org/10.1016/j.cllc.2022.02.001.

Article  PubMed  Google Scholar 

Robinson CG, Patel AP, Bradley JD, DeWees T, Waqar SN, Morgensztern D, et al. Postoperative radiotherapy for pathologic N2 non-small-cell lung cancer treated with adjuvant chemotherapy: a review of the National Cancer Data Base. J Clin Oncol. 2015;33:870–6. https://doi.org/10.1200/JCO.2014.58.5380.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lally BE, Zelterman D, Colasanto JM, Haffty BG, Detterbeck FC, Wilson LD. Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database. J Clin Oncol. 2006;24:2998–3006. https://doi.org/10.1200/JCO.2005.04.6110.

Article  PubMed  Google Scholar 

Le Pechoux C, Pourel N, Barlesi F, Lerouge D, Antoni D, Lamezec B, et al. Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (lung ART): an open-label, randomised, phase 3 trial. Lancet Oncol. 2022;23:104–14. https://doi.org/10.1016/S1470-2045(21)00606-9.

Article  PubMed  Google Scholar 

Hui Z, Men Y, Hu C, Kang J, Sun X, Bi N, et al. Effect of postoperative radiotherapy for patients with pIIIA-N2 Non-small Cell Lung Cancer after Complete Resection and Adjuvant Chemotherapy: the phase 3 PORT-C randomized clinical trial. JAMA Oncol. 2021;7:1178–85. https://doi.org/10.1001/jamaoncol.2021.1910.

Article  PubMed  Google Scholar 

Ma Z, Liang B, Wei R, Liu Y, Bao Y, Yuan M, et al. Enhanced prediction of postoperative radiotherapy-induced esophagitis in non-small cell lung cancer: dosiomic model development in a real-world cohort and validation in the PORT-C randomized controlled trial. Thorac Cancer. 2023;14:2839–45. https://doi.org/10.1111/1759-7714.15068.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma Z, Liu Y, Bao Y, Yuan M, Yang X, Men Y, et al. Higher lung and heart doses decrease early and long-term survival, Respectively, in patients with Non-small Cell Lung Cancer Undergoing Postoperative Radiation. Adv Radiation Oncol. 2023;8:101213. https://doi.org/10.1016/j.adro.2023.101213.

Article  Google Scholar 

Ma Z, Yang X, Hui Z. Association of Heart Base Dose with overall survival in patients with NSCLC undergoing postoperative Radiotherapy. J Thorac Oncol. 2023;18:e62–4. https://doi.org/10.1016/j.jtho.2023.03.007.

Article  PubMed  Google Scholar 

Sun X, Men Y, Wang J, Bao Y, Yang X, Zhao M, et al. Risk of cardiac-related mortality in stage IIIA-N2 non-small cell lung cancer: analysis of the Surveillance, Epidemiology, and end results (SEER) database. Thorac Cancer. 2021;12:1358–65. https://doi.org/10.1111/1759-7714.13908.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dai H, Hui Z, Ji W, Liang J, Lu J, Ou G, et al. Postoperative radiotherapy for resected pathological stage IIIA-N2 non-small cell lung cancer: a retrospective study of 221 cases from a single institution. Oncologist. 2011;16:641–50. https://doi.org/10.1634/theoncologist.2010-0343.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hui Z, Dai H, Liang J, Lv J, Zhou Z, Feng Q, et al. Selection of proper candidates with resected pathological stage IIIA-N2 non-small cell lung cancer for postoperative radiotherapy. Thorac Cancer. 2015;6:346–53. https://doi.org/10.1111/1759-7714.12186.

Article  PubMed  PubMed Central  Google Scholar 

Huang S, Yang J, Shen N, Xu Q, Zhao Q. Artificial intelligence in lung cancer diagnosis and prognosis: current application and future perspective. Sem Cancer Biol. 2023;89:30–7. https://doi.org/10.1016/j.semcancer.2023.01.006.

Article  Google Scholar 

NSCLC Radiogenomics - The Cancer Imaging Archive (TCIA) Public Access - Cancer Imaging Archive Wiki. 2023/7/5. https://wiki.cancerimagingarchive.net/display/Public/NSCLC+Radiogenomics. Accessed 5 Jul 2023.

NSCLC-Radiomics - The Cancer Imaging Archive (TCIA) Public Access - Cancer Imaging Archive Wiki. 2023/3/6. https://wiki.cancerimagingarchive.net/display/Public/NSCLC-Radiomics. Accessed 6 Mar 2023.

The Cancer Genome Atlas Lung Adenocarcinoma Collection (TCGA-LUAD) - The Cancer Imaging Archive (TCIA) Public Access - Cancer Imaging Archive Wiki. 2023/7/5. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=6881474. Accessed 5 Jul 2023.

The Cancer Genome Atlas Lung Squamous Cell Carcinoma Collection (TCGA-LUSC) - The Cancer Imaging Archive (TCIA) Public Access - Cancer Imaging Archive Wiki. 2023/7/5. https://wiki.cancerimagingarchive.net/pages/viewpage.action?pageId=16056484. Accessed 5 Jul 2023.

Mackin D, Ger R, Gay S, Dodge C, Zhang L, Yang J, et al. Matching and homogenizing Convolution kernels for quantitative studies in computed tomography. Invest Radiol. 2019;54:288–95. https://doi.org/10.1097/RLI.0000000000000540.

Article  PubMed  PubMed Central  Google Scholar 

GEO Accession viewer. 2023/7/5. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE103584. Accessed 5 Jul 2023.

Liu Y, Wang Y, Wang X, Xue L, Zhang H, Ma Z, et al. MR radiomics predicts pathological complete response of esophageal squamous cell carcinoma after neoadjuvant chemoradiotherapy: a multicenter study. Cancer Imaging. 2024;24:16. https://doi.org/10.1186/s40644-024-00659-x.

Article  PubMed  PubMed Central  Google Scholar 

Vaidya P, Bera K, Gupta A, Wang X, Corredor G, Fu P, et al. CT derived radiomic score for predicting the added benefit of adjuvant chemotherapy following surgery in stage I, II resectable non-small cell lung cancer: a retrospective multicohort study for outcome prediction. Lancet Digit Health. 2020;2:e116–28. https://doi.org/10.1016/S2589-7500(20)30002-9.

Article  PubMed  PubMed Central  Google Scholar 

Wang T, She Y, Yang Y, Liu X, Chen S, Zhong Y, et al. Radiomics for Survival Risk Stratification of Clinical and Pathologic Stage IA pure-solid Non-small Cell Lung Cancer. Radiology. 2022;302:425–34. https://doi.org/10.1148/radiol.2021210109.

Article  PubMed  Google Scholar 

Yuan M, Men Y, Kang J, Sun X, Zhao M, Bao Y, et al. Postoperative radiotherapy for pathological stage IIIA-N2 non-small cell lung cancer with positive surgical margins. Thorac Cancer. 2021;12:227–34. https://doi.org/10.1111/1759-7714.13749.

Article  CAS  PubMed  Google Scholar 

Bao Y, Yang X, Men Y, Kang J, Sun X, Zhao M, et al. Postoperative radiotherapy improves survival of patients with ypN2 non-small cell lung cancer after neoadjuvant chemotherapy followed by surgery - A propensity score matching study of the Surveillance, Epidemiology, and end results database. Thorac Cancer. 2022;13:404–11. https://doi.org/10.1111/1759-7714.14273.

Article  PubMed  Google Scholar 

Zhang C-C, Yu W, Zhang Q, Cai X-W, Feng W, Fu X-L. A decision support framework for postoperative radiotherapy in patients with pathological N2 non-small cell lung cancer. Radiother Oncol. 2022;173:313–8. https://doi.org/10.1016/j.radonc.2022.06.017.

Article  CAS  PubMed  Google Scholar 

Yu L, Tao G, Zhu L, Wang G, Li Z, Ye J, Chen Q. Prediction of pathologic stage in non-small cell lung cancer using machine learning algorithm based on CT image feature analysis. BMC Cancer. 2019;19:464. https://doi.org/10.1186/s12885-019-5646-9.

Article  PubMed  PubMed Central  Google Scholar 

Ferreira-Junior JR, Koenigkam-Santos M, Magalhães Tenório AP, Faleiros MC, Garcia Cipriano FE, Fabro AT, et al. CT-based radiomics for prediction of histologic subtype and metastatic disease in primary malignant lung neoplasms. Int J Comput Assist Radiol Surg. 2020;15:163–72. https://doi.org/10.1007/s11548-019-02093-y.

Article  PubMed  Google Scholar 

Choi Y, Aum J, Lee S-H, Kim H-K, Kim J, Shin S, et al. Deep learning analysis of CT images reveals high-Grade pathological features to Predict Survival in Lung Adenocarcinoma. Cancers (Basel). 2021. https://doi.org/10.3390/cancers13164077.

Article  PubMed  PubMed Central  Google Scholar 

Ding X, Hui Z, Dai H, Fan C, Men Y, Ji W, et al. A proposal for combination of lymph node ratio and anatomic location of involved lymph nodes for nodal classification in Non-small Cell Lung Cancer. J Thorac Oncol. 2016;11:1565–73. https://doi.org/10.1016/j.jtho.2016.05.004.

Article  PubMed  Google Scholar 

Deng W, Xu T, Xu Y, Wang Y, Liu X, Zhao Y, et al. Survival patterns for patients with resected N2 Non-small Cell Lung Cancer and Postoperative Radiotherapy: a Prognostic Scoring Model and Heat Map Approach. J Thorac Oncol. 2018;13:1968–74. https://doi.org/10.1016/j.jtho.2018.08.2021.

Article  PubMed  PubMed Central  Google Scholar 

Chiappetta M, Leuzzi G, Sperduti I, Bria E, Mucilli F, Lococo F, et al. Mediastinal Up-Staging during surgery in Non-small-cell Lung Cancer: which Mediastinal Lymph Node metastasis patterns better predict the outcome? A Multicenter Analysis. Clin Lung Cancer. 2020;21:464–e4711. https://doi.org/10.1016/j.cllc.2020.03.004.

Article  PubMed  Google Scholar 

Zarinshenas R, Ladbury C, McGee H, Raz D, Erhunmwunsee L, Pathak R, et al. Machine learning to refine prognostic and predictive nodal burden thresholds for post-operative radiotherapy in completely resected stage III-N2 non-small cell lung cancer. Radiother Oncol. 2022;173:10–8. https://doi.org/10.1016/j.radonc.2022.05.019.

Article  CAS  PubMed  Google Scholar 

Coroller TP, Agrawal V, Huynh E, Narayan V, Lee SW, Mak RH, Aerts HJWL. Radiomic-based pathological response prediction from primary tumors and Lymph nodes in NSCLC. J Thorac Oncol. 2017;12:467–76. https://doi.org/10.1016/j.jtho.2016.11.2226.

Article  PubMed  Google Scholar