Sahai E, Astsaturov I, Cukierman E, DeNardo DG, Egeblad M, Evans RM, et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat Rev Cancer. 2020;20:174–86. https://doi.org/10.1038/s41568-019-0238-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Prive BM, Boussihmad MA, Timmermans B, van Gemert WA, Peters SMB, Derks YHW, et al. Fibroblast activation protein-targeted radionuclide therapy: background, opportunities, and challenges of first (pre)clinical studies. Eur J Nucl Med Mol Imaging. 2023;50:1906–18. https://doi.org/10.1007/s00259-023-06144-0.

Article  PubMed  PubMed Central  Google Scholar 

Zhang Z, Tao J, Qiu J, Cao Z, Huang H, Xiao J, et al. From basic research to clinical application: targeting fibroblast activation protein for cancer diagnosis and treatment. Cell Oncol (Dordr). 2023. https://doi.org/10.1007/s13402-023-00872-z.

Article  PubMed  Google Scholar 

Giesel FL, Kratochwil C, Lindner T, Marschalek MM, Loktev A, Lehnert W, et al. 68Ga-FAPI PET/CT: Biodistribution and preliminary Dosimetry Estimate of 2 DOTA-Containing FAP-Targeting agents in patients with various cancers. J Nucl Med. 2019;60:386–92. https://doi.org/10.2967/jnumed.118.215913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kratochwil C, Flechsig P, Lindner T, Abderrahim L, Altmann A, Mier W, et al. 68Ga-FAPI PET/CT: Tracer Uptake in 28 different kinds of Cancer. J Nucl Med. 2019;60:801–5. https://doi.org/10.2967/jnumed.119.227967.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Toms J, Kogler J, Maschauer S, Daniel C, Schmidkonz C, Kuwert T, et al. Targeting fibroblast activation protein: Radiosynthesis and preclinical evaluation of an 18F-Labeled FAP inhibitor. J Nucl Med. 2020;61:1806–13. https://doi.org/10.2967/jnumed.120.242958.

Article  CAS  PubMed  Google Scholar 

Lai C, Cao R, Li R, He C, Wang X, Shi H, et al. Fibroblast activation protein targeting probe with gly-pro sequence for PET of Glioblastoma. Mol Pharm. 2023;20:4120–8. https://doi.org/10.1021/acs.molpharmaceut.3c00248.

Article  CAS  PubMed  Google Scholar 

Kersemans K, De Man K, Courtyn J, Van Royen T, Piron S, Moerman L, et al. Automated radiosynthesis of Al[18F]PSMA-11 for large scale routine use. Appl Radiat Isot. 2018;135:19–27. https://doi.org/10.1016/j.apradiso.2018.01.006.

Article  CAS  PubMed  Google Scholar 

Boellaard R, Delgado-Bolton R, Oyen WJ, Giammarile F, Tatsch K, Eschner W, et al. FDG PET/CT: EANM procedure guidelines for tumour imaging: version 2.0. Eur J Nucl Med Mol Imaging. 2015;42:328–54. https://doi.org/10.1007/s00259-014-2961-x.

Article  CAS  PubMed  Google Scholar 

Wasserthal J, Breit HC, Meyer MT, Pradella M, Hinck D, Sauter AW, et al. TotalSegmentator: robust segmentation of 104 anatomic structures in CT images. Radiol Artif Intell. 2023;5:e230024. https://doi.org/10.1148/ryai.230024.

Article  PubMed  PubMed Central  Google Scholar 

Fedorov A, Beichel R, Kalpathy-Cramer J, Finet J, Fillion-Robin JC, Pujol S, et al. 3D slicer as an image computing platform for the quantitative Imaging Network. Magn Reson Imaging. 2012;30:1323–41. https://doi.org/10.1016/j.mri.2012.05.001.

Article  PubMed  PubMed Central  Google Scholar 

Beichel RR, Van Tol M, Ulrich EJ, Bauer C, Chang T, Plichta KA, et al. Semiautomated segmentation of head and neck cancers in 18F-FDG PET scans: a just-enough-interaction approach. Med Phys. 2016;43:2948–64. https://doi.org/10.1118/1.4948679.

Article  PubMed  PubMed Central  Google Scholar 

Sharma V, McNeill JH. To scale or not to scale: the principles of dose extrapolation. Br J Pharmacol. 2009;157:907–21. https://doi.org/10.1111/j.1476-5381.2009.00267.x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Demetrius L. Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans. EMBO Rep. 2005;6:39–44. https://doi.org/10.1038/sj.embor.7400422. Spec No:S.

Article  CAS  Google Scholar 

Wang S, Zhou X, Xu X, Ding J, Liu T, Jiang J, et al. Dynamic PET/CT imaging of 68Ga-FAPI-04 in Chinese subjects. Front Oncol. 2021;11:651005. https://doi.org/10.3389/fonc.2021.651005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kumar S, Borish K, Dey S, Nagesh J, Das A. Sequence dependent folding motifs of the secondary structures of gly-pro and Pro-gly containing oligopeptides. Phys Chem Chem Phys. 2022;24:18408–18. https://doi.org/10.1039/d2cp01306a.

Article  CAS  PubMed  Google Scholar 

Minelli A, Conte C, Cacciatore I, Cornacchia C, Pinnen F. Molecular mechanism underlying the cerebral effect of gly-pro-glu tripeptide bound to L-dopa in a Parkinson’s animal model. Amino Acids. 2012;43:1359–67. https://doi.org/10.1007/s00726-011-1210-x.

Article  CAS  PubMed  Google Scholar 

Ding H, Liang J, Qiu L, Xu T, Cai L, Wan Q, et al. Prospective comparison of 68Ga-FAPI-04 and 18F-FDG PET/CT for tumor staging in nasopharyngeal carcinoma. Front Oncol. 2022;12:1047010. https://doi.org/10.3389/fonc.2022.1047010.

Article  PubMed  PubMed Central  Google Scholar 

Qin C, Liu F, Huang J, Ruan W, Liu Q, Gai Y, et al. A head-to-head comparison of 68Ga-DOTA-FAPI-04 and 18F-FDG PET/MR in patients with nasopharyngeal carcinoma: a prospective study. Eur J Nucl Med Mol Imaging. 2021;48:3228–37. https://doi.org/10.1007/s00259-021-05255-w.

Article  CAS  PubMed  Google Scholar 

Wang L, Tang G, Hu K, Liu X, Zhou W, Li H, et al. Comparison of 68Ga-FAPI and 18F-FDG PET/CT in the evaluation of Advanced Lung Cancer. Radiology. 2022;303:191–9. https://doi.org/10.1148/radiol.211424.

Article  PubMed  Google Scholar 

Li M, Younis MH, Zhang Y, Cai W, Lan X. Clinical summary of fibroblast activation protein inhibitor-based radiopharmaceuticals: cancer and beyond. Eur J Nucl Med Mol Imaging. 2022;49:2844–68. https://doi.org/10.1007/s00259-022-05706-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen R, Yang X, Yu X, Zhou X, Ng YL, Zhao H, et al. Tumor-to-blood ratio for assessment of fibroblast activation protein receptor density in pancreatic cancer using 68Ga-FAPI-04. Eur J Nucl Med Mol Imaging. 2023;50:929–36. https://doi.org/10.1007/s00259-022-06010-5.

Article  CAS  PubMed  Google Scholar 

Wang L, Wang Y, Wang J, Xiao M, Xi XY, Chen BX, et al. Myocardial activity at 18F-FAPI PET/CT and risk for Sudden Cardiac Death in Hypertrophic Cardiomyopathy. Radiology. 2023;306:e221052. https://doi.org/10.1148/radiol.221052.

Article  PubMed  Google Scholar 

Zhang X, Song W, Qin C, Song Y, Liu F, Hu F, et al. Uterine uptake of 68Ga-FAPI-04 in Uterine Pathology and Physiology. Clin Nucl Med. 2022;47:7–13. https://doi.org/10.1097/RLU.0000000000003968.

Article  PubMed  Google Scholar 

Nakamoto Y, Baba S, Kaida H, Manabe O, Uehara T. Recent topics in fibroblast activation protein inhibitor-PET/CT: clinical and pharmacological aspects. Ann Nucl Med. 2024;38:10–9. https://doi.org/10.1007/s12149-023-01873-6.

Article  PubMed  Google Scholar 

Pang Y, Zhao L, Luo Z, Hao B, Wu H, Lin Q, et al. Comparison of 68Ga-FAPI and 18F-FDG uptake in gastric, duodenal, and colorectal cancers. Radiology. 2021;298:393–402. https://doi.org/10.1148/radiol.2020203275.

Article  PubMed  Google Scholar 

Cai J, Yang D, Sun H, Xiao L, Han F, Zhang M, et al. A multifactorial analysis of FAP to regulate gastrointestinal cancers progression. Front Immunol. 2023;14:1183440. https://doi.org/10.3389/fimmu.2023.1183440.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhao L, Pang Y, Luo Z, Fu K, Yang T, Zhao L, et al. Role of 68Ga-DOTA-FAPI-04 PET/CT in the evaluation of peritoneal carcinomatosis and comparison with 18F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 2021;48:1944–55. https://doi.org/10.1007/s00259-020-05146-6.

Article  CAS  PubMed  Google Scholar 

Pure E, Blomberg R. Pro-tumorigenic roles of fibroblast activation protein in cancer: back to the basics. Oncogene. 2018;37:4343–57. https://doi.org/10.1038/s41388-018-0275-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Braune A, Oehme L, Freudenberg R, Hofheinz F, van den Hoff J, Kotzerke J, et al. Comparison of image quality and spatial resolution between 18F, 68Ga, and 64Cu phantom measurements using a digital Biograph Vision PET/CT. EJNMMI Phys. 2022;9:58. https://doi.org/10.1186/s40658-022-00487-7.

Article  PubMed  PubMed Central  Google Scholar