The response of pancreatic acinar cell carcinoma to platinum and olaparib therapy in a germline BRCA2 variant carrier: case report and literature review

Wood LD, Klimstra DS (2014) Pathology and genetics of pancreatic neoplasms with acinar differentiation. Semin Diagn Pathol 31:491–497

Article  PubMed  PubMed Central  Google Scholar 

Calimano-Ramirez LF, Daoud T, Gopireddy DR et al (2022) Pancreatic acinar cell carcinoma: a comprehensive review. World J Gastroenterol 28:5827–5844

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsubayashi H, Todaka A, Kawakami T et al (2023) Genetic medicine in companion diagnostics of germline BRCA testing of Japanese pancreatic cancer patients. J Hum Genet 68:81–86

Article  CAS  PubMed  Google Scholar 

Mizukami K, Iwasaki Y, Kawakami E et al (2020) Genetic characterization of pancreatic cancer patients and prediction of carrier status of germline pathogenic variants in cancer-predisposing genes. EBioMedicine 60:103033

Article  PubMed  PubMed Central  Google Scholar 

Furukawa T, Sakamoto H, Takeuchi S et al (2015) Whole exome sequencing reveals recurrent mutations in BRCA2 and FAT genes in acinar cell carcinomas of the pancreas. Sci Rep 5:8829

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee CL, Holter S, Borgida A et al (2022) Germline BRCA2 variants in advanced pancreatic acinar cell carcinoma: a case report and review of literature. World J Gastroenterol 28:6421–6432

Article  PubMed  PubMed Central  Google Scholar 

Mandelker D, Marra A, Zheng-Lin B et al (2023) Genomic profiling reveals germline predisposition and homologous recombination deficiency in pancreatic acinar cell carcinoma. J Clin Oncol 41:5151–5162

Article  CAS  PubMed  Google Scholar 

Lelong M, Raoul JL, Touchefeu Y et al (2022) Prolonged response on olaparib maintenance in metastatic pancreatic acinar cell carcinoma associated with a germline BRCA 2 mutation, revealed by severe panniculitis. Clin Case Rep 10:e6718

Article  PubMed  PubMed Central  Google Scholar 

Li M, Mou Y, Hou S et al (2018) Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: a case report. Medicine (Baltimore) 97:e13113

Article  PubMed  Google Scholar 

Xu JY, Guan WL, Lu SX et al (2022) Optimizing chemotherapy of pancreatic acinar cell carcinoma: our experiences and pooled analysis of literature. Clin Med Insights Oncol 16:11795549221090186

Article  PubMed  PubMed Central  Google Scholar 

Takahashi H, Ikeda M, Shiba S et al (2021) Multicenter retrospective analysis of chemotherapy for advanced pancreatic acinar cell carcinoma: potential efficacy of platinum- and irinotecan-containing regimens. Pancreas 50:77–82

Article  PubMed  Google Scholar 

Eisenhauer EA, Therasse P, Bogaerts J et al (2009) New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer 45:228–47

Robson M, Im SA, Senkus E et al (2017) Olaparib for metastatic breast cancer in patients with a germline BRCA mutation. N Engl J Med 377:523–533

Article  CAS  PubMed  Google Scholar 

Mirza MR, Monk BJ, Herrstedt J et al (2016) Niraparib maintenance therapy in platinum-sensitive, recurrent ovarian cancer. N Engl J Med 375:2154–2164

Article  CAS  PubMed  Google Scholar 

Golan T, Hammel P, Reni M et al (2019) Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer. N Engl J Med 381:317–327

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sunami T, Yamada A, Kondo T et al (2022) Exceptional response of pancreatic acinar cell carcinoma and bile duct cancer to platinum-based chemotherapy in a family with a germline BRCA2 variant. Pancreas 51:1258–1262

Article  CAS  PubMed  Google Scholar 

Okusaka T, Nakamura M, Yoshida M et al (2023) Clinical practice guidelines for pancreatic cancer 2022 from the japan pancreas society: a synopsis. Int J Clin Oncol 28:493–511

Article  PubMed  PubMed Central  Google Scholar 

Golan T, O’Kane GM, Denroche RE et al (2021) Genomic features and classification of homologous recombination deficient pancreatic ductal adenocarcinoma. Gastroenterology 160(2119–2132):e9

Google Scholar 

Florou V, Elliott A, Bailey MH et al (2023) Comparative genomic analysis of pancreatic acinar cell carcinoma (PACC) and pancreatic ductal adenocarcinoma (PDAC) unveils new actionable genomic aberrations in PACC. Clin Cancer Res 29:3408–3417

Article  CAS  PubMed  Google Scholar 

Dreikhausen L, Schulte N, Belle S et al (2021) Pancreatic acinar cell carcinoma with germline BRCA2 mutation and severe pancreatic panniculitis: a case report. Visc Med 37:447–450

Article  PubMed  PubMed Central  Google Scholar 

Okawa Y, Iwasaki Y, Johnson TA et al (2023) Hereditary cancer variants and homologous recombination deficiency in biliary tract cancer. J Hepatol 78:333–342

Article  CAS  PubMed  Google Scholar 

Ueki A, Yoshida R, Kosaka T et al (2023) Clinical risk management of breast, ovarian, pancreatic, and prostatic cancers for BRCA1/2 variant carriers in Japan. J Hum Genet 68:517–526

Article  CAS  PubMed  Google Scholar 

Momozawa Y, Sasai R, Usui Y et al (2022) Expansion of cancer risk profile for BRCA1 and BRCA2 pathogenic variants. JAMA Oncol 8:871–878

Article  PubMed  PubMed Central  Google Scholar 

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