Wołącewicz M, Hrynkiewicz R, Grywalska E, Suchojad T, Leksowski T, Roliński J, Niedźwiedzka-Rystwej P. Immunotherapy in bladder cancer: current methods and future perspectives. Cancers. 2020. https://doi.org/10.3390/cancers12051181.

Article  PubMed  PubMed Central  Google Scholar 

Feng D, Li D, Wu R, Han P. Scientific advancements in drug development and trials for urothelial carcinoma: insights from the 2023 ASCO-GU cancers symposium. Aging Dis. 2023;14(6):1953–7. https://doi.org/10.14336/AD.2023.0502.

Article  PubMed  PubMed Central  Google Scholar 

Lenis AT, Lec PM, Chamie K, Mshs MD. Bladder cancer: a review. Jama-J Am Med Assoc. 2020;324(19):1980–91. https://doi.org/10.1001/jama.2020.17598.

Article  CAS  Google Scholar 

Tuo Z, Feng D, Jiang Z, Bi L, Yang C, Wang Q. Unveiling clinical significance and tumor immune landscape of CXCL12 in bladder cancer: insights from multiple omics analysis. Chinese J Cancer Res. 2023;35(6):686–701. https://doi.org/10.21147/j.issn.1000-9604.2023.06.12.

Article  Google Scholar 

Zeng S, Ying Y, Xing N, Wang B, Qian Z, Zhou Z, Zhang Z, Xu W, Wang H, Dai L, et al. Noninvasive detection of urothelial carcinoma by cost-effective low-coverage whole-genome sequencing from urine-exfoliated cell DNA. Clin Cancer Res. 2020;26(21):5646–54. https://doi.org/10.1158/1078-0432.CCR-20-0401.

Article  CAS  PubMed  Google Scholar 

Ahmadi H, Duddalwar V, Daneshmand S. Diagnosis and staging of bladder cancer. Hematol Oncol Clin N. 2021;35(3):531–41. https://doi.org/10.1016/j.hoc.2021.02.004.

Article  Google Scholar 

Wang L, Chen S, Luo Y, Yuan L, Peng T, Qian K, Liu X, Xiao Y, Wang X. Identification of several cell cycle relevant genes highly correlated with the progression and prognosis of human bladder urothelial tumor. J Cell Physiol. 2019;234(8):13439–51. https://doi.org/10.1002/jcp.28023.

Article  CAS  PubMed  Google Scholar 

Xiong Y, Ju L, Yuan L, Chen L, Wang G, Xu H, Peng T, Luo Y, Xiao Y, Wang X. KNSTRN promotes tumorigenesis and gemcitabine resistance by activating AKT in bladder cancer. Oncogene. 2021;40(9):1595–608. https://doi.org/10.1038/s41388-020-01634-z.

Article  CAS  PubMed  Google Scholar 

Wang X, Bai Y, Zhang F, Yang Y, Feng D, Li A, Yang Z, Li D, Tang Y, Wei X, et al. Targeted inhibition of P4HB promotes cell sensitivity to gemcitabine in urothelial carcinoma of the bladder. Oncotargets Ther. 2020;13:9543–58. https://doi.org/10.2147/OTT.S267734.

Article  CAS  Google Scholar 

Zou T, Lin Z. The involvement of ubiquitination machinery in cell cycle regulation and cancer progression. Int J Mol Sci. 2021. https://doi.org/10.3390/ijms22115754.

Article  PubMed  PubMed Central  Google Scholar 

Shah MA, Abuzar SM, Ilyas K, Qadees I, Bilal M, Yousaf R, Kassim R, Rasul A, Saleem U, Alves MS, et al. Ginsenosides in cancer: Targeting cell cycle arrest and apoptosis. Chem-Biol Interact. 2023;382:110634. https://doi.org/10.1016/j.cbi.2023.110634.

Article  CAS  PubMed  Google Scholar 

Li T, Wang L, Yu N, Zeng A, Huang J, Long X. CDCA3 is a prognostic biomarker for cutaneous melanoma and is connected with immune infiltration. Front Oncol. 2022;12:1055308. https://doi.org/10.3389/fonc.2022.1055308.

Article  CAS  PubMed  Google Scholar 

Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004;432(7015):316–23. https://doi.org/10.1038/nature03097.

Article  CAS  PubMed  Google Scholar 

Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411(6835):342–8. https://doi.org/10.1038/35077213.

Article  CAS  PubMed  Google Scholar 

Yang Y, Miao L, Lu Y, Sun Y, Wang S. Exosome, the glass slipper for cinderella of cancer-bladder cancer? J Nanobiotechnol. 2023;21(1):368. https://doi.org/10.1186/s12951-023-02130-8.

Article  Google Scholar 

Rabbani F, Cordon-Cardo C. Mutation of cell cycle regulators and their impact on superficial bladder cancer. Urol Clin N Am. 2000;27(1):83–102. https://doi.org/10.1016/s0094-0143(05)70237-8.

Article  CAS  Google Scholar 

Whitfield ML, George LK, Grant GD, Perou CM. Common markers of proliferation. Nat Rev Cancer. 2006;6(2):99–106. https://doi.org/10.1038/nrc1802.

Article  CAS  PubMed  Google Scholar 

Dai H, Van’T VL, Lamb J, He YD, Mao M, Fine BM, Bernards R, van de Vijver M, Deutsch P, Sachs A, et al. A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients. Cancer Res. 2005;65(10):4059–66. https://doi.org/10.1158/0008-5472.CAN-04-3953.

Article  CAS  PubMed  Google Scholar 

Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, et al. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. New Engl J Med. 2002;346(25):1937–47. https://doi.org/10.1056/NEJMoa012914.

Article  PubMed  Google Scholar 

Gao M, Tuo Z, Jiang Z, Chen Z, Wang J. Dysregulated ANLN reveals immune cell landscape and promotes carcinogenesis by regulating the PI3K/Akt/mTOR pathway in clear cell renal cell carcinoma. Heliyon. 2024;10(1):e23522. https://doi.org/10.1016/j.heliyon.2023.e23522.

Article  CAS  PubMed  Google Scholar 

Li Q, Zhang P, Hu H, Huang H, Pan D, Mao G, Hu B. The DDR-related gene signature with cell cycle checkpoint function predicts prognosis, immune activity, and chemoradiotherapy response in lung adenocarcinoma. Resp Res. 2022;23(1):190. https://doi.org/10.1186/s12931-022-02110-w.

Article  CAS  Google Scholar 

Zhou Y, Lei D, Hu G, Luo F. A cell cycle-related 13-mrna signature to predict prognosis in hepatocellular carcinoma. FRONT ONCOL. 2022;12:760190. https://doi.org/10.3389/fonc.2022.760190.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang LQ, Zhou SL, Li JK, Chen PN, Zhao XK, Wang LD, Li XL, Zhou FY. Identification of a seven-cell cycle signature predicting overall survival for gastric cancer. Aging. 2022;14(9):3989–99. https://doi.org/10.18632/aging.204060.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim WJ, Kim EJ, Kim SK, Kim YJ, Ha YS, Jeong P, Kim MJ, Yun SJ, Lee KM, Moon SK, et al. Predictive value of progression-related gene classifier in primary non-muscle invasive bladder cancer. Mol Cancer. 2010;9:3. https://doi.org/10.1186/1476-4598-9-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, Wilson CJ, Lehár J, Kryukov GV, Sonkin D, et al. The cancer cell line encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603–7. https://doi.org/10.1038/nature11003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP, Tamayo P. The molecular signatures database (MSigDB) hallmark gene set collection. Cell Syst. 2015;1(6):417–25. https://doi.org/10.1016/j.cels.2015.12.004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Fang X, Lu L, Liu G. Prognostic significance and immune landscape of a fatty acid metabolism-related gene signature in colon adenocarcinoma. Front Genet. 2022;13:996625. https://doi.org/10.3389/fgene.2022.996625.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mayakonda A, Lin DC, Assenov Y, Plass C, Koeffler HP. Maftools: efficient and comprehensive analysis of somatic variants in cancer. Genome Res. 2018;28(11):1747–56. https://doi.org/10.1101/gr.239244.118.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Malta TM, Sokolov A, Gentles AJ, Burzykowski T, Poisson L, Weinstein JN, Kamińska B, Huelsken J, Omberg L, Gevaert O, et al. Machine learning identifies stemness features associated with oncogenic dedifferentiation. Cell. 2018;173(2):338–54. https://doi.org/10.1016/j.cell.2018.03.034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Newman AM, Liu CL, Green MR, Gentles AJ, Feng W, Xu Y, Hoang CD, Diehn M, Alizadeh AA. Robust enumeration of cell subsets from tissue expression profiles. Nat Methods. 2015;12(5):453–7. https://doi.org/10.1038/nmeth.3337.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu T, Hu E, Xu S, Chen M, Guo P, Dai Z, Feng T, Zhou L, Tang W, Zhan L, et al. clusterProfiler 4.0: a universal enrichment tool for interpreting omics data. Innovation. 2021. https://doi.org/10.1016/j.xinn.2021.100141.

Article  PubMed  PubMed Central  Google Scholar 

Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK. limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res. 2015;43(7): e47. https://doi.org/10.1093/nar/gkv007.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hänzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-seq data. Bmc Bioinformat. 2013. https://d