Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC, Grosshans D, Khatua S, Ketonen L, Fontanilla H, McGovern SL (2019) A phase 1/2 trial of reirradiation for diffuse intrinsic pontine glioma. Int J Radiat Oncol Biol Phys 104(1):144–148. https://doi.org/10.1016/j.ijrobp.2018.12.043

Article  PubMed  Google Scholar 

Cohen KJ, Jabado N, Grill J (2017) Diffuse intrinsic pontine gliomas-current management and new biologic insights. Is there a glimmer of hope? Neuro Oncol 19(8):1025–1034. https://doi.org/10.1093/neuonc/nox021

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cooney TM, Cohen KJ, Guimaraes CV, Dhall G, Leach J, Massimino M, Erbetta A, Chiapparini L, Malbari F, Kramer K, Pollack IF, Baxter P, Laughlin S, Patay Z, Young Poussaint T, Warren KE (2020) Response assessment in diffuse intrinsic pontine glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 21(6):e330–e336. https://doi.org/10.1016/S1470-2045(20)30166-2

Article  PubMed  Google Scholar 

D’Arco F, O’Hare P, Dashti F, Lassaletta A, Loka T, Tabori U, Talenti G, Thust S, Messalli G, Hales P, Bouffet E, Laughlin S (2018) Volumetric assessment of tumor size changes in pediatric low-grade gliomas: feasibility and comparison with linear measurements. Neuroradiology 60(4):427–436. https://doi.org/10.1007/s00234-018-1979-3

Article  PubMed  Google Scholar 

Erker C, Tamrazi B, Poussaint TY, Mueller S, Mata-Mbemba D, Franceschi E, Brandes AA, Rao A, Haworth KB, Wen PY, Goldman S, Vezina G, MacDonald TJ, Dunkel IJ, Morgan PS, Jaspan T, Prados MD, Warren KE (2020) Response assessment in paediatric high-grade glioma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol 21(6):e317–e329. https://doi.org/10.1016/S1470-2045(20)30173-X

Article  CAS  PubMed  Google Scholar 

Gilligan LA, DeWire-Schottmiller MD, Fouladi M, DeBlank P, Leach JL (2020) Tumor Response Assessment in diffuse intrinsic pontine glioma: comparison of Semiautomated Volumetric, Semiautomated Linear, and Manual Linear Tumor Measurement Strategies. AJNR Am J Neuroradiol 41(5):866–873. https://doi.org/10.3174/ajnr.A6555

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hargrave D, Bartels U, Bouffet E (2006) Diffuse brainstem glioma in children: critical review of clinical trials. Lancet Oncol 7(3):241–248. https://doi.org/10.1016/S1470-2045(06)70615-5

Article  PubMed  Google Scholar 

Hargrave D, Chuang N, Bouffet E (2008) Conventional MRI cannot predict survival in childhood diffuse intrinsic pontine glioma. J Neurooncol 86(3):313–319. https://doi.org/10.1007/s11060-007-9473-5

Article  PubMed  Google Scholar 

Hassan H, Pinches A, Picton SV, Phillips RS (2017) Survival rates and prognostic predictors of high grade brain stem gliomas in childhood: a systematic review and meta-analysis. J Neurooncol 135(1):13–20. https://doi.org/10.1007/s11060-017-2546-1

Article  PubMed  PubMed Central  Google Scholar 

Hayward RM, Patronas N, Baker EH, Vezina G, Albert PS, Warren KE (2008) Inter-observer variability in the measurement of diffuse intrinsic pontine gliomas. J Neurooncol 90(1):57–61. https://doi.org/10.1007/s11060-008-9631-4

Article  PubMed  PubMed Central  Google Scholar 

Hoffman LM, van Veldhuijzen SEM, Colditz N, Baugh J, Chaney B, Hoffmann M, Lane A, Fuller C, Miles L, Hawkins C, Bartels U, Bouffet E, Goldman S, Leary S, Foreman NK, Packer R, Warren KE, Broniscer A, Kieran MW, Minturn J, Comito M, Broxson E, Shih CS, Khatua S, Chintagumpala M, Carret AS, Escorza NY, Hassall T, Ziegler DS, Gottardo N, Dholaria H, Doughman R, Benesch M, Drissi R, Nazarian J, Jabado N, Boddaert N, Varlet P, Giraud G, Castel D, Puget S, Jones C, Hulleman E, Modena P, Giagnacovo M, Antonelli M, Pietsch T, Gielen GH, Jones DTW, Sturm D, Pfister SM, Gerber NU, Grotzer MA, Pfaff E, von Bueren AO, Hargrave D, Solanki GA, Jadrijevic Cvrlje F, Kaspers GJL, Vandertop WP, Grill J, Bailey S, Biassoni V, Massimino M, Calmon R, Sanchez E, Bison B, Warmuth-Metz M, Leach J, Jones B, van Vuurden DG, Kramm CM, Fouladi M (2018) Clinical, radiologic, pathologic, and molecular characteristics of long-term survivors of diffuse intrinsic pontine glioma (DIPG): a collaborative report from the International and European Society for Pediatric Oncology DIPG Registries. J Clin Oncol 36(19):1963–1972. https://doi.org/10.1200/JCO.2017.75.9308

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jansen MH, van Veldhuijzen SE, Sanchez Aliaga E, Heymans MW, Warmuth-Metz M, Hargrave D, van der Hoeven EJ, Gidding CE, de Bont ES, Eshghi OS, Reddingius R, Peeters CM, Schouten-van Meeteren AY, Gooskens RH, Granzen B, Paardekooper GM, Janssens GO, Noske DP, Barkhof F, Kramm CM, Vandertop WP, Kaspers GJ, van Vuurden DG (2015) Survival prediction model of children with diffuse intrinsic pontine glioma based on clinical and radiological criteria. Neuro Oncol 17(1):160–166. https://doi.org/10.1093/neuonc/nou104

Article  PubMed  Google Scholar 

Janssens GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K, Benghiat H, Hoeben B, Morales La Madrid A, Kortmann RD, Hargrave D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG, Massimino M, Sturm D, Peters M, Kramm CM (2017) Survival benefit for patients with diffuse intrinsic pontine glioma (DIPG) undergoing re-irradiation at first progression: a matched-cohort analysis on behalf of the SIOP-E-HGG/DIPG working group. Eur J Cancer 73:38–47. https://doi.org/10.1016/j.ejca.2016.12.007

Article  PubMed  Google Scholar 

Kim HJ, Lee JH, Kim Y, Lim DH, Park SH, Ahn SD, Kim IA, Im JH, Chung JW, Kim JY, Kim IH, Yoon HI, Suh CO (2023) Suggestions for escaping the Dark ages for Pediatric diffuse intrinsic pontine glioma treated with Radiotherapy: analysis of prognostic factors from the National Multicenter Study. Cancer Res Treat 55(1):41–49. https://doi.org/10.4143/crt.2021.1514

Article  CAS  PubMed  Google Scholar 

Lassaletta A, Strother D, Laperriere N, Hukin J, Vanan MI, Goddard K, Lafay-Cousin L, Johnston DL, Zelcer S, Zapotocky M, Rajagopal R, Ramaswamy V, Hawkins C, Tabori U, Huang A, Bartels U, Bouffet E (2018) Reirradiation in patients with diffuse intrinsic pontine gliomas: the Canadian experience. Pediatr Blood Cancer 65(6):e26988. https://doi.org/10.1002/pbc.26988

Article  PubMed  Google Scholar 

Lazow MA, Nievelstein MT, Lane A, Bandopadhayhay P, DeWire-Schottmiller M, Fouladi M, Glod JW, Greiner RJ, Hoffman LM, Hummel TR, Kilburn L, Leary S, Minturn JE, Packer R, Ziegler DS, Chaney B, Black K, de Blank P, Leach JL (2022) Volumetric endpoints in diffuse intrinsic pontine glioma: comparison to cross-sectional measures and outcome correlations in the International DIPG/DMG Registry. Neuro Oncol 24(9):1598–1608. https://doi.org/10.1093/neuonc/noac037

Article  CAS  PubMed  PubMed Central  Google Scholar 

Leach JL, Roebker J, Schafer A, Baugh J, Chaney B, Fuller C, Fouladi M, Lane A, Doughman R, Drissi R, DeWire-Schottmiller M, Ziegler DS, Minturn JE, Hansford JR, Wang SS, Monje-Deisseroth M, Fisher PG, Gottardo NG, Dholaria H, Packer R, Warren K, Leary SES, Goldman S, Bartels U, Hawkins C, Jones BV (2020) MR imaging features of diffuse intrinsic pontine glioma and relationship to overall survival: report from the International DIPG Registry. Neuro Oncol 22(11):1647–1657. https://doi.org/10.1093/neuonc/noaa140

Article  PubMed  PubMed Central  Google Scholar 

Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, Hawkins C, Ng HK, Pfister SM, Reifenberger G, Soffietti R, von Deimling A, Ellison DW (2021) The 2021 WHO classification of tumors of the Central Nervous System: a summary. Neuro Oncol 23(8):1231–1251. https://doi.org/10.1093/neuonc/noab106

Article  CAS  PubMed  PubMed Central  Google Scholar 

Makepeace L, Scoggins M, Mitrea B, Li Y, Edwards A, Tinkle CL, Hwang S, Gajjar A, Patay Z (2020) MRI patterns of Extrapontine Lesion extension in diffuse intrinsic pontine gliomas. AJNR Am J Neuroradiol 41(2):323–330. https://doi.org/10.3174/ajnr.A6391

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morana G, Tortora D, Bottoni G, Puntoni M, Piatelli G, Garibotto F, Barra S, Giannelli F, Cistaro A, Severino M, Verrico A, Milanaccio C, Massimino M, Garre ML, Rossi A, Piccardo A (2020) Correlation of multimodal (18)F-DOPA PET and conventional MRI with treatment response and survival in children with diffuse intrinsic pontine gliomas. Theranostics 10(26):11881–11891. https://doi.org/10.7150/thno.50598

Article  CAS  PubMed  PubMed Central  Google Scholar 

Poussaint TY, Kocak M, Vajapeyam S, Packer RI, Robertson RL, Geyer R, Haas-Kogan D, Pollack IF, Vezina G, Zimmerman R, Cha S, Patay Z, Boyett JM, Kun LE (2011) MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol 13(4):417–427. https://doi.org/10.1093/neuonc/noq200

Article  PubMed  PubMed Central  Google Scholar 

Riley GT, Armitage PA, Batty R, Griffiths PD, Lee V, McMullan J, Connolly DJ (2015) Diffuse intrinsic pontine glioma: is MRI surveillance improved by region of interest volumetry? Pediatr Radiol 45(2):203–210. https://doi.org/10.1007/s00247-014-3134-6

Article  PubMed  Google Scholar 

Sedlacik J, Winchell A, Kocak M, Loeffler RB, Broniscer A, Hillenbrand CM (2013) MR imaging assessment of tumor perfusion and 3D segmented volume at baseline, during treatment, and at tumor progression in children with newly diagnosed diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol 34(7):1450–1455. https://doi.org/10.3174/ajnr.A3421

Article  CAS  PubMed  PubMed Central  Google Scholar 

Warren KE, Poussaint TY, Vezina G, Hargrave D, Packer RJ, Goldman S, Wen PY, Pollack IF, Zurakowski D, Kun LE, Prados MD, Rutkowski S, Kieran MW (2013) Challenges with defining response to antitumor agents in pediatric neuro-oncology: a report from the response assessment in pediatric neuro-oncology (RAPNO) working group. Pediatr Blood Cancer 60(9):1397–1401. https://doi.org/10.1002/pbc.24562

Article  PubMed  PubMed Central  Google Scholar 

Wen PY, Macdonald DR, Reardon DA, Cloughesy TF, Sorensen AG, Galanis E, Degroot J, Wick W, Gilbert MR, Lassman AB, Tsien C, Mikkelsen T, Wong ET, Chamberlain MC, Stupp R, Lamborn KR, Vogelbaum MA, van den Bent MJ, Chang SM (2010) Updated response assessment criteria for high-grade gliomas: response assessment in neuro-oncology working group. J Clin Oncol 28(11):1963–1972. https://doi.org/10.1200/JCO.2009.26.3541

Article  PubMed  Google Scholar 

Yamasaki F, Kurisu K, Kajiwara Y, Watanabe Y, Takayasu T, Akiyama Y, Saito T, Hanaya R, Sugiyama K (2011) Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma. Neuro Oncol 13(7):791–801. https://doi.org/10.1093/neuonc/nor038

Article  PubMed  PubMed Central  Google Scholar