Piñana JL, Pérez A, Chorão P, Guerreiro M, García-Cadenas I, Solano C, et al. Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Respiratory virus infections after allogeneic stem cell transplantation: current understanding, knowledge gaps, and recent advances. Transpl Infect Dis. 2023;25:e14117 https://doi.org/10.1111/tid.14117.

Article  CAS  PubMed  Google Scholar 

Rachow T, Lamik T, Kalkreuth J, Kurze S, Wagner K, Stier P, et al. Detection of community acquired respiratory viruses in allogeneic stem-cell transplant recipients and controls-a prospective cohort study. Transpl Infect Dis. 2020;22:e13415 https://doi.org/10.1111/tid.13415.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fontana L, Strasfeld L. Respiratory virus infections of the stem cell transplant recipient and the hematologic malignancy pa-tient. Infect Dis Clin North Am. 2019;33:523–44. https://doi.org/10.1016/j.idc.2019.02.004.

Article  PubMed  PubMed Central  Google Scholar 

Seo S, Martin M, Xie H, Kuypers JM, Campbell AP, Choi SM, et al. Human rhinovirus RNA detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality. Biol Blood Marrow Transpl. 2013;19:S167–S168. https://doi.org/10.1016/j.bbmt.2012.11.139.

Article  Google Scholar 

Ghosh S, Champlin R, Couch R, Englund J, Raad I, Malik S, et al. Rhinovirus infections in myelosuppressed adult blood and marrow transplant recipients. Clin Infect Dis. 1999;29:528–32.

Article  CAS  PubMed  Google Scholar 

Kraft CS, Jacob JT, Sears MH, Burd EM, Caliendo AM, Lyon GM. Severity of human rhinovirus infection in immunocompromised adults is similar to that of 2009 H1N1 influenza. J Clin Microbiol. 2012;50:1061–3.

Article  PubMed  PubMed Central  Google Scholar 

Ogimi C, Waghmare AA, Kuypers JM, Xie H, Yeung CC, Leisenring WM, et al. Clinical significance of human coronavirus in bronchoalveolar lavage samples from hematopoietic cell transplant recipients and patients with hematologic malignancies. Clin Infect Dis. 2017;64:1532–9. https://doi.org/10.1093/cid/cix160.

Article  CAS  PubMed  Google Scholar 

Renaud C, Xie H, Seo S, Kuypers J, Cent A, Corey L, et al. Mortality rates of human metapneumovirus and respiratory syncytial virus lower respiratory tract infections in hematopoietic cell transplantation recipients. Biol Blood Marrow Transpl. 2013;19:1220–6. https://doi.org/10.1016/j.bbmt.2013.05.005.

Article  Google Scholar 

Seo S, Waghmare A, Scott EM, Xie H, Kuypers JM, Hackman RC, et al. Human rhinovirus detection in the lower respiratory tract of hematopoietic cell transplant recipients: association with mortality. Haematologica. 2017;102:1120–30. https://doi.org/10.3324/haematol.2016.153767.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piñana JL, Pérez A, Montoro J, Hernani R, Lorenzo I, Giménez E, et al. The effect of timing on community acquired respiratory virus infection mortality during the first year after allogeneic hematopoietic stem cell transplantation: a prospective epidemiological survey. Bone Marrow Transpl. 2020;55:431–40. https://doi.org/10.1038/s41409-019-0698-7.

Article  CAS  Google Scholar 

Piñana JL, Pérez A, Montoro J, Giménez E, Gómez MD, Lorenzo I, et al. Clinical effectiveness of influenza vaccination after allogeneic hematopoietic stem cell transplantation: a cross-sectional, prospective, observational study. Clin Infect Dis. 2019;68:1894–903. https://doi.org/10.1093/cid/ciy792.

Article  CAS  PubMed  Google Scholar 

Piñana JL, Gómez MD, Pérez A, Madrid S, Balaguer-Roselló A, Giménez E, et al. Community-acquired respiratory virus lower respiratory tract disease in allogeneic stem cell transplantation recipient: risk factors and mortality from pulmonary virus-bacterial mixed infections. Transpl Infect Dis. 2018;20:e12926.

Article  PubMed  PubMed Central  Google Scholar 

Ljungman P, Tridello G, Piñana JL, Ciceri F, Sengeloev H, Kulagin A, et al. Improved outcomes over time and higher mortality in CMV seropositive allogeneic stem cell transplantation patients with COVID-19; An infectious disease working party study from the European Society for Blood and Marrow Transplantation registry. Front Immunol. 2023;14:1125824 https://doi.org/10.3389/fimmu.2023.1125824.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piñana JL, Hernández-Boluda JC, Calabuig M, Ballester I, Marín M, Madrid S, et al. A risk-adapted approach to treating respiratory syncytial virus and human parainfluenza virus in allogeneic stem cell transplantation recipients with oral ribavirin therapy: a pilot study. Transpl Infect Dis. 2017;19. https://doi.org/10.1111/tid.12729.

Seo S, Xie H, Campbell AP, Kuypers JM, Leisenring WM, Englund JA, et al. Parainfluenza virus lower respiratory tract disease after hematopoietic cell transplant: viral detection in the lung predicts outcome. Clin Infect Dis. 2014;58:1357–68.

Article  PubMed  Google Scholar 

Shah DP, Ghantoji SS, Ariza-Heredia EJ, Shah JN, El Taoum KK, Shah PK, et al. Immunodeficiency scoring index to predict poor outcomes in hematopoi-etic cell transplant recipients with RSV infections. Blood. 2014;123:3263–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Austin PC. A tutorial on multilevel survival analysis: methods, models and applications. Int Stat Rev. 2017;85:185–203. https://doi.org/10.1111/insr.12214.

Article  PubMed  PubMed Central  Google Scholar 

Piñana JL, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, et al. Seasonal human coronavirus respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. J Infect Dis. 2021;223:1564–75. https://doi.org/10.1093/infdis/jiaa553.

Article  CAS  PubMed  Google Scholar 

Nichols WG, Corey L, Gooley T, Davis C, Boeckh M. Parainfluenza virus infections after hematopoietic stem cell transplanta-tion: risk factors, response to antiviral therapy, and effect on transplant outcome. Blood. 2001;98:573–8.

Article  CAS  PubMed  Google Scholar 

Chemaly RF, Hanmod SS, Rathod DB, Ghantoji SS, Jiang Y, Doshi A, et al. The characteristics and outcomes of parainfluenza virus infections in 200 patients with leukemia or recipients of hematopoietic stem cell transplantation. Blood. 2012;119:2738–45.

Article  CAS  PubMed  Google Scholar 

Piñana JL, Tridelo G, Xhaard A, Wendel L, Montoro J, Vazquez L, et al. Upper and/or lower respiratory tract infection caused by human metapneumovirus after allogeneic hematopoietic stem cell transplantation. J Infect Dis. 2023;jiad268. https://doi.org/10.1093/infdis/jiad268.

Ljungman P, de la Camara R, Mikulska M, Tridello G, Aguado B, Zahrani MA, et al. COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey. Leukemia. 2021;35:2885–94. https://doi.org/10.1038/s41375-021-01302-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piñana JL, López-Corral L, Martino R, Vazquez L, Pérez A, Martin-Martin G, et al. Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). SARS-CoV-2 vaccine response and rate of breakthrough infection in patients with hematological disorders. J Hematol Oncol. 2022;15:54. https://doi.org/10.1186/s13045-022-01275-7.

Piñana JL, Heras I, Aiello TF, García-Cadenas I, Vazquez L, Lopez-Jimenez J, et al. Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). Remdesivir or Nirmatrelvir/Ritonavir Therapy for Omicron SARS-CoV-2 Infection in Hematological Patients and Cell Therapy Recipients. Viruses. 2023;15:2066 https://doi.org/10.3390/v15102066.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chartrand C, Tremblay N, Renaud C, Papenburg J. Diagnostic accuracy of rapid antigen detection tests for respiratory syncytial virus infection: systematic review and meta-analysis. J Clin Microbiol. 2015;53:3738–49.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aiello TF, Salmanton-Garcia J, Marchesi F, Weinbergerova B, Glenthoj A, Van Praet J, et al. Dexamethasone Treatment for COVID-19 is Related with Increased Mortality in Haematological Malignancy Patients: Results from the EPICOVIDEHA Registry. Available at SSRN: https://ssrn.com/abstract=4473151 or https://doi.org/10.2139/ssrn.4473151.

Regan P, Elkhalifa S, Barratt P. The systemic immunosuppressive effects of peripheral corticosteroid injections: a narrative review of the evidence in the context of COVID-19. Musculoskelet Care. 2022;20:431–41. https://doi.org/10.1002/msc.1603.

Article  Google Scholar 

Piñana JL, López-Corral L, Martino R, Montoro J, Vazquez L, Pérez A, et al. Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH-TC). SARS-CoV-2-reactive antibody detection after SARS-CoV-2 vaccination in hematopoietic stem cell transplant recipients: prospective survey from the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group. Am J Hematol. 2022;97:30–42. https://doi.org/10.1002/ajh.26385.

Article  CAS  PubMed  Google Scholar 

Redjoul R, Le Bouter A, Beckerich F, Fourati S, Maury S. Antibody response after second BNT162b2 dose in allogeneic HSCT recipients. Lancet. 2021;398:298–299. https://doi.org/10.1016/S0140-6736(21)01594-4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vasileiou S, Turney AM, Kuvalekar M, Mukhi SS, Watanabe A, Lulla P, et al. Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections. Haematologica. 2020;105:235–43. https://doi.org/10.3324/haematol.2018.206896.

Article  CAS  PubMed  PubMed Central  Google Scholar