This review provides an exploration of trance states, covering their phenomenology, neural mechanisms, and clinical uses. Trance states, present in diverse cultural contexts from shamanic practices to modern adaptations, have recently captured the interest of researchers and clinicians. Here, we delve into the phenomenological aspects of trance experiences, highlighting the most common features. Employing cutting-edge neuroscientific methods, we also report findings on the neural underpinnings of trance states. Furthermore, we look into the practical applications of such states in clinical settings. By bridging subjective experiences, neuroscience, and clinical relevance, this review enhances our understanding of trance states and their possible uses.