Functional metabolomics characterizes the contribution of farnesoid X receptor in pyrrolizidine alkaloid-induced hepatic sinusoidal obstruction syndrome

Aubrecht J, Schomaker SJ, Amacher DE (2013) Emerging hepatotoxicity biomarkers and their potential to improve understanding and management of drug-induced liver injury. Genome Med 5(9):85

Article  PubMed  PubMed Central  Google Scholar 

Beger RD, Dunn WB, Bandukwala A, Bethan B, Broadhurst D, Clish CB, Dasari S, Derr L, Evans A, Fischer S, Flynn T, Hartung T, Herrington D, Higashi R, Hsu PC, Jones C, Kachman M, Karuso H, Kruppa G, Lippa K, Maruvada P, Mosley J, Ntai I, O’Donovan C, Playdon M, Raftery D, Shaughnessy D, Souza A, Spaeder T, Spalholz B, Tayyari F, Ubhi B, Verma M, Walk T, Wilson I, Witkin K, Bearden DW, Zanetti KA (2019) Towards quality assurance and quality control in untargeted metabolomics studies. Metabolomics 15(1):4

Article  PubMed  PubMed Central  Google Scholar 

Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR (2021) Practice parameters committee of the american college of gastroenterology. ACG clinical guideline: diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol 116(5):878–898

Article  CAS  PubMed  Google Scholar 

Chen WH, Wei YR, Xiong AZ, Li YM, Guan H, Wang Q, Miao Q, Bian Z, Xiao X, Lian M, Zhang J, Li B, Cao Q, Fan Z, Zhang W, Qiu D, Fang J, Gershwin ME, Yang L, Tang RQ, Ma X (2020a) Comprehensive analysis of serum and fecal bile acid profiles and interaction with gut microbiota in Primary Biliary Cholangitis. Clin Rev Allergy Immunol 58(1):25–38

Article  PubMed  Google Scholar 

Chen Y, Xiong F, Wang WQ, Jiang KY, Ye XL, Deng G, Wang CH, Yang L, Xiong AZ, Wang ZT (2020b) The long persistence of pyrrolizidine alkaloid-derived pyrrole-protein adducts in vivo: kinetic study following multiple exposures of a pyrrolizidine alkaloid containing extract of Gynura japonica. Toxicol Lett 323:41–47

Article  CAS  PubMed  Google Scholar 

Chiang JY (2003) Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol 284(3):G349–G356

Article  CAS  PubMed  Google Scholar 

Danan G, Bénichou C (1993) Causality assessment of adverse reactions to drugs–I. A novel method based on the conclusions of international consensus meetings: Application to drug-induced liver injuries. J Clin Epidemiol 46:1323–1330

Article  CAS  PubMed  Google Scholar 

DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel GC (1999) Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology 29:1779–1791

Article  CAS  PubMed  Google Scholar 

DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X, McCuskey RS (2003) Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol 284:G1045–G1052

Article  CAS  PubMed  Google Scholar 

Ding LL, Zhang EY, Yang Q, Jin L, Sousa KM, Dong B, Wang Y, Tu J, Ma X, Tian J, Zhang H, Fang Z, Guan A, Zhang Y, Wang ZT, Moore DD, Yang L, Huang WD (2021) Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice. Proc Natl Acad Sci U S A 118:e2019388118

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao H, Ruan JQ, Chen J, Li N, Ke CQ, Ye Y, Lin G, Wang JY (2015) Blood pyrrole-protein adducts as a diagnostic and prognostic index in pyrrolizidine alkaloid-hepatic sinusoidal obstruction syndrome. Drug Des Devel Ther 9:4861–4868

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghallab A, Hassan R, Hofmann U, Friebel A, Hobloss Z, Brackhagen L, Begher-Tibbe B, Myllys M, Reinders J, Overbeck N, Sezgin S, Zühlke S, Seddek AL, Murad W, Brecklinghaus T, Kappenberg F, Rahnenführer J, González D, Goldring C, Copple IM, Marchan R, Longerich T, Vucur M, Luedde T, Urban S, Canbay A, Schreiter T, Trauner M, Akakpo JY, Olyaee M, Curry SC, Sowa JP, Jaeschke H, Hoehme S, Hengstler JG (2022) Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity. J Hepatol 77(1):71–83

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewei SA (2000) A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 6:517–526

Article  CAS  PubMed  Google Scholar 

He Y, Ma J, Fan X, Ding L, Ding X, Zhang QY, Lin G (2021) The key role of gut-liver axis in pyrrolizidine alkaloid-induced hepatotoxicity and enterotoxicity. Acta Pharm Sin B 11(12):3820–3835

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hessel-Pras S, Braeuning A, Guenther G, Adawy A, Enge AM, Ebmeyer J, Henderson CJ, Hengstler JG, Lampen A, Reif R (2020) The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice. Arch Toxicol 94:219–229

Article  CAS  PubMed  Google Scholar 

Hoofnagle JH, Björnsson ES (2019) Drug-induced liver injury—types and phenotypes. N Engl J Med 381:264–273

Article  CAS  PubMed  Google Scholar 

Huang ZL, Jing X, Sheng Y, Zhang J, Hao Z, Wang ZT, Ji LL (2019) (-)-Epicatechin attenuates hepatic sinusoidal obstruction syndrome by inhibiting liver oxidative and inflammatory injury. Redox Biol 22:101117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, Luo G, Jones SA, Goodwin B, Richardson JA, Gerard RD, Repa JJ, Mangelsdorf DJ, Kliewer SA (2005) Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2:217–225

Article  CAS  PubMed  Google Scholar 

IPCS; International Programme on Chemical Safety (1988) Environmental health criteria 80: pyrrolizidine alkaloids. World Health Organization, Geneva

Google Scholar 

Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG, Vogelsang GB, Sensenbrenner LL, Santos GW, Saral R (1987) Venoocclusive disease of the liver following bone marrow transplantation. Transplantation 44:778–783

Article  CAS  PubMed  Google Scholar 

Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA (2010) Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Mol Endocrinol 24:1626–1636

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li-Hawkins J, Gåfvels M, Olin M, Lund EG, Andersson U, Schuster G, Björkhem I, Russell DW, Eggertsen G (2002) Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. J Clin Invest 110:1191–1200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin G, Wang JY, Li N, Li M, Gao H, Ji Y, Zhang F, Wang H, Zhou Y, Ye Y, Xu HX, Zheng J (2011) Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum. J Hepatology 54(4):666–673

Article  Google Scholar 

Makishima M, Okamoto AY, Repa JJ, Tu H, Learned RM, Luk A, Hull MV, Lustig KD, Mangelsdorf DJ, Shan B (1999) Identification of a nuclear receptor for bile acids. Science 284:1362–1365

Article  CAS  PubMed  Google Scholar 

McDonald GB, Sharma P, Matthews DE, Shulman HM, Thomas ED (1984) Venocclusive disease of the liver after bone marrow transplantation: diagnosis, incidence, and predisposing factors. Hepatology 4:116–122

Article  CAS  PubMed  Google Scholar 

Mendel VE, Witt MR, Gitchell BS, Gribble DN, Rogers QR, Segall HJ, Knight HD (1988) Pyrrolizidine alkaloid-induced liver disease in horses: an early diagnosis. Am J Vet Res 49:572–578

CAS  PubMed  Google Scholar 

Mohty M, Malard F, Abecassis M, Aerts E, Alaskar AS, Aljurf M, Arat M, Bader P, Baron F, Bazarbachi A, Blaise D, Ciceri F, Corbacioglu S, Dalle JH, Dignan F, Fukuda T, Huynh A, Masszi T, Michallet M, Nagler A, NiChonghaile M, Okamoto S, Pagliuca A, Peters C, Petersen FB, Richardson PG, Ruutu T, Savani BN, Wallhult E, Yakoub-Agha I, Duarte RF, Carreras E (2016) Revised diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a new classification from the European Society for Blood and Marrow Transplantation. Bone Marrow Transplant 51:906–912

Article  CAS  PubMed  PubMed Central  Google Scholar 

Myant NB, Mitropoulos KA (1977) Cholesterol 7 alpha-hydroxylase. J Lipid Res 18(2):135–153

Article  CAS  PubMed  Google Scholar 

Nevens F, Andreone P, Mazzella G, Strasser SI, Bowlus C, Invernizzi P, Drenth JP, Pockros PJ, Regula J, Beuers U, Trauner M, Jones DE, Floreani A, Hohenester S, Luketic V, Shiffman M, van Erpecum KJ, Vargas V, Vincent C, Hirschfield GM, Shah H, Hansen B, Lindor KD, Marschall HU, Kowdley KV, Hooshmand-Rad R, Marmon T, Sheeron S, Pencek R, MacConell L, Pruzanski M, Shapiro D, POISE Study Group (2016) A placebo-controlled trial of obeticholic acid in primary biliary cholangitis. N Engl J Med 375:631–643

Article  CAS  PubMed  Google Scholar 

Pang X, Tang C, Cao P, Zhou L, Chen X (2021) Metabolic activation of retrorsine may disrupt bile acid homeostasis in mice through the Nrf2 pathway. Curr Drug Metab 22(11):870–881

Article  CAS  PubMed  Google Scholar 

Parks DJ, Blanchard SG, Bledsoe RK, Chandra G, Consler TG, Kliewer SA, Stimmel JB, Willson TM, Zavacki AM, Moore DD, Lehmann JM (1999) Bile acids: Natural ligands for an orphan nuclear receptor. Science 284:1365–1368

Article  CAS  PubMed  Google Scholar 

Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM (2002) 6α-Ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 45:3569–3572

Article  CAS  PubMed  Google Scholar 

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