The study conducted by Clair et al 1 reported in this issue of JECH delves into the intricate relationship between housing circumstances and epigenetic ageing, offering valuable insights into the complex interplay between genetics, environment and health outcomes through the novel perspective offered by DNA methylation data. The study ventures into relatively uncharted territory, seeking to illuminate how the place we call home might influence the fundamental biological processes underlying ageing. Their analysis hinges on the concept of epigenetic ageing, a burgeoning field of research that examines how external factors can imprint themselves on our DNA, potentially accelerating or decelerating the biological clock.

Clair et al tentatively suggest that living in privately rented homes might be linked to an accelerated biological ageing process. This assertion, however, is made cautiously, acknowledging the need for further investigation to establish a definitive causal link. Interestingly, this potential impact of housing circumstances on ageing appears to be more pronounced than the effects of certain other well-established risk factors, such as unemployment or a history of smoking. This empirical insight advances our understanding of how social determinants, such as housing, can influence health at a molecular level. The study’s contributions extend beyond the contemporary, delving into historical housing circumstances to provide a more comprehensive understanding of the potential impact of how housing circumstances across the life course may influence health. Elements such as repeated housing payment arrears and exposure to pollution also appear to be associated with accelerated biological ageing. This underscores the intricate interplay between past experiences …