Johnson, R. E., Washington, M. T., Haracska, L., Prakash, S. & Prakash, L. Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions. Nature 406, 1015–1019 (2000).
Article CAS PubMed Google Scholar
Jain, R., Aggarwal, A. K. & Rechkoblit, O. Eukaryotic DNA polymerases. Curr. Opin. Struct. Biol. 53, 77–87 (2018).
Article CAS PubMed Google Scholar
Prakash, S., Johnson, R. E. & Prakash, L. Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function. Annu. Rev. Biochem. 74, 317–353 (2005).
Article CAS PubMed Google Scholar
Johnson, R. E., Prakash, L. & Prakash, S. Pol31 and Pol32 subunits of yeast DNA polymerase ẟ are also essential subunits of DNA polymerase ζ. Proc. Natl Acad. Sci. USA 109, 12455–12460 (2012).
Article CAS PubMed PubMed Central Google Scholar
Makarova, A. V., Stodola, J. L. & Burgers, P. M. A four-subunit DNA polymerase ζ complex containing Pol ẟ accessory subunits is essential for PCNA-mediated mutagenesis. Nucleic Acids Res. 40, 11618–11626 (2012).
Article CAS PubMed PubMed Central Google Scholar
Makarova, A. V. & Burgers, P. M. Eukaryotic DNA polymerase ζ. DNA Repair (Amst.) 29, 47–55 (2015).
Article CAS PubMed Google Scholar
Lange, S. S., Takata, K. & Wood, R. D. DNA polymerases and cancer. Nat. Rev. Cancer 11, 96–110 (2011).
Article CAS PubMed PubMed Central Google Scholar
Nelson, J. R., Lawrence, C. W. & Hinkle, D. C. Thymine–thymine dimer bypass by yeast DNA polymerase ζ. Science 272, 1646–1649 (1996).
Article CAS PubMed Google Scholar
Malik, R. et al. Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch. Nat. Commun. 13, 1050 (2022).
Article CAS PubMed PubMed Central Google Scholar
Malik, R. et al. Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis. Nat. Struct. Mol. Biol. 27, 913–924 (2020).
Article CAS PubMed PubMed Central Google Scholar
Hashimoto, K. et al. The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site. J. Biol. Chem. 287, 9613–9622 (2012).
Article CAS PubMed PubMed Central Google Scholar
Doles, J. et al. Suppression of Rev3, the catalytic subunit of Polζ, sensitizes drug-resistant lung tumors to chemotherapy. Proc. Natl Acad. Sci. USA 107, 20786–20791 (2010).
Article CAS PubMed PubMed Central Google Scholar
Xie, K., Doles, J., Hemann, M. T. & Walker, G. C. Error-prone translesion synthesis mediates acquired chemoresistance. Proc. Natl Acad. Sci. USA 107, 20792–20797 (2010).
Article CAS PubMed PubMed Central Google Scholar
Xu, X. et al. Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug. Proc. Natl Acad. Sci. USA 110, 18638–18643 (2013).
Article CAS PubMed PubMed Central Google Scholar
Nelson, J. R., Lawrence, C. W. & Hinkle, D. C. Deoxycytidyl transferase activity of yeast REV1 protein. Nature 382, 729–731 (1996).
Article CAS PubMed Google Scholar
Nair, D. T., Johnson, R. E., Prakash, L., Prakash, S. & Aggarwal, A. K. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science 309, 2219–2222 (2005).
Article CAS PubMed Google Scholar
Guo, C. et al. Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. EMBO J. 22, 6621–6630 (2003).
Article CAS PubMed PubMed Central Google Scholar
Ohashi, E. et al. Interaction of hREV1 with three human Y-family DNA polymerases. Genes Cells 9, 523–531 (2004).
Article CAS PubMed Google Scholar
Tissier, A. et al. Co-localization in replication foci and interaction of human Y-family members, DNA polymerase polη and REV1 protein. DNA Repair 3, 1503–1514 (2004).
Article CAS PubMed Google Scholar
Haracska, L. et al. Roles of yeast DNA polymerases ẟ and ζ and of Rev1 in the bypass of abasic sites. Genes Dev. 15, 945–954 (2001).
Article CAS PubMed PubMed Central Google Scholar
Pozhidaeva, A. et al. NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η. Biochemistry 51, 5506–5520 (2012).
Article CAS PubMed Google Scholar
Xie, W., Yang, X., Xu, M. & Jiang, T. Structural insights into the assembly of human translesion polymerase complexes. Protein Cell 3, 864–874 (2012).
Article CAS PubMed PubMed Central Google Scholar
Wojtaszek, J. et al. Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and ϰ. J. Biol. Chem. 287, 26400–26408 (2012).
Article CAS PubMed PubMed Central Google Scholar
Futreal, P. A. et al. BRCA1 mutations in primary breast and ovarian carcinomas. Science 266, 120–122 (1994).
Article CAS PubMed Google Scholar
Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71 (1994).
Article CAS PubMed Google Scholar
Callebaut, I. & Mornon, J. P. From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair. FEBS Lett. 400, 25–30 (1997).
Article CAS PubMed Google Scholar
Bork, P. et al. A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins. FASEB J. 11, 68–76 (1997).
Article CAS PubMed Google Scholar
Manke, I. A., Lowery, D. M., Nguyen, A. & Yaffe, M. B. BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Science 302, 636–639 (2003).
Article CAS PubMed Google Scholar
Yu, X., Chini, C. C., He, M., Mer, G. & Chen, J. The BRCT domain is a phospho-protein binding domain. Science 302, 639–642 (2003).
Article CAS PubMed Google Scholar
Lawrence, C. W. Cellular functions of DNA polymerase ζ and Rev1 protein. Adv. Protein Chem. 69, 167–203 (2004).
Article CAS PubMed Google Scholar
Guo, C. et al. REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo. Mol. Cell 23, 265–271 (2006).
Article CAS PubMed Google Scholar
Kobayashi, M., Figaroa, F., Meeuwenoord, N., Jansen, L. E. & Siegal, G. Characterization of the DNA binding and structural properties of the BRCT region of human replication factor C p140 subunit. J. Biol. Chem. 281, 4308–4317 (2006).
Article CAS PubMed Google Scholar
de Groote, F. H. et al. The Rev1 translesion synthesis polymerase has multiple distinct DNA binding modes. DNA Repair (Amst.) 10, 915–925 (2011).
Kochenova, O. V. et al. Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations. Nucleic Acids Res. 45, 1200–1218 (2017).
Article CAS PubMed Google Scholar
Pages, V. et al. Requirement of Rad5 for DNA polymerase ζ-dependent translesion synthesis in Saccharomyces cerevisiae. Genetics 180, 73–82 (2008).
Article CAS PubMed PubMed Central Google Scholar
Kuang, L. et al. A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5. DNA Repair (Amst.) 12, 27–37 (2013).
留言 (0)