Matot, I., and C.L. Sprung. 2001. Definition of sepsis. Intensive Care Medicine 27 (Suppl 1): S3-9.

Article  PubMed  Google Scholar 

Guo, N.K., H. She, L. Tan, Y.Q. Zhou, C.Q. Tang, X.Y. Peng, C.H. Ma, T. Li, and L.M. Liu. 2023. Nano Parthenolide Improves Intestinal Barrier Function of Sepsis by Inhibiting Apoptosis and ROS via 5-HTR2A. International Journal of Nanomedicine 18: 693–709.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shen, X.F., K. Cao, J.P. Jiang, W.X. Guan, and J.F. Du. 2017. Neutrophil dysregulation during sepsis: An overview and update. Journal of Cellular and Molecular Medicine 21 (9): 1687–1697.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gotts, J.E., and M.A. Matthay. 2016. Sepsis: Pathophysiology and clinical management. BMJ (Clinical Research ed.) 353: i1585.

PubMed  Google Scholar 

Bauernfeind, F.G., G. Horvath, A. Stutz, E.S. Alnemri, K. MacDonald, D. Speert, T. Fernandes-Alnemri, J. Wu, B.G. Monks, K.A. Fitzgerald, V. Hornung, and E. Latz. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. Journal of Immunology (Baltimore, Md. : 1950) 183 (2): 787–91.

Article  CAS  PubMed  Google Scholar 

Bai, B., Y. Yang, Q. Wang, M. Li, C. Tian, Y. Liu, L.H.H. Aung, P.F. Li, T. Yu, and X.M. Chu. 2020. NLRP3 inflammasome in endothelial dysfunction. Cell Death & Disease 11 (9): 776.

Article  CAS  Google Scholar 

Xie, Z., H. Hou, D. Luo, R. An, Y. Zhao, and C. Qiu. 2021. ROS-dependent lipid peroxidation and reliant antioxidant ferroptosis-suppressor-protein 1 in rheumatoid arthritis: A covert clue for potential therapy. Inflammation 44 (1): 35–47.

Article  CAS  PubMed  Google Scholar 

He, R., B. Liu, R. Xiong, B. Geng, H. Meng, W. Lin, B. Hao, L. Zhang, W. Wang, W. Jiang, N. Li, and Q. Geng. 2022. Itaconate inhibits ferroptosis of macrophage via Nrf2 pathways against sepsis-induced acute lung injury. Cell Death Discovery 8 (1): 43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang, X., J. Liu, S. Yao, J. Zheng, X. Gong, and B. Xiao. 2022. Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis. Pharmaceutical Biology 60 (1): 2286–2294.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tu, Y., J. Liu, D. Kong, X. Guo, J. Li, Z. Long, J. Peng, Z. Wang, H. Wu, P. Liu, R. Liu, W. Yu, and W. Li. 2023. Irisin drives macrophage anti-inflammatory differentiation via JAK2-STAT6-dependent activation of PPARγ and Nrf2 signaling. Free Radical Biology & Medicine 201: 98–110.

Article  CAS  Google Scholar 

Luo, J., J. Wang, J. Zhang, A. Sang, X. Ye, Z. Cheng, and X. Li. 2022. Nrf2 deficiency exacerbated CLP-induced pulmonary injury and inflammation through autophagy- and NF-κB/PPARγ-mediated macrophage polarization. Cells 11 (23).

Li, X., M. Jamal, P. Guo, Z. Jin, F. Zheng, X. Song, J. Zhan, and H. Wu. 2019. Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 118: 109363.

Deng, Z., M. Sun, J. Wu, H. Fang, S. Cai, S. An, Q. Huang, Z. Chen, C. Wu, Z. Zhou, H. Hu, and Z. Zeng. 2021. SIRT1 attenuates sepsis-induced acute kidney injury via Beclin1 deacetylation-mediated autophagy activation. Cell Death & Disease 12 (2): 217.

Article  CAS  Google Scholar 

Xu, D., L. Liu, Y. Zhao, L. Yang, J. Cheng, R. Hua, Z. Zhang, and Q. Li. 2020. Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner. Journal of Pineal Research 69 (4).

Article  CAS  PubMed  Google Scholar 

Feng, K., Z. Chen, L. Pengcheng, S. Zhang, and X. Wang. 2019. Quercetin attenuates oxidative stress-induced apoptosis via SIRT1/AMPK-mediated inhibition of ER stress in rat chondrocytes and prevents the progression of osteoarthritis in a rat model. Journal of Cellular Physiology 234 (10): 18192–18205.

Article  CAS  PubMed  Google Scholar 

Xie, W., L. Deng, M. Lin, X. Huang, R. Qian, D. Xiong, W. Liu, and S. Tang. 2023. Sirtuin1 mediates the protective effects of echinacoside against sepsis-induced acute lung injury via regulating the NOX4-Nrf2 axis. Antioxidants (Basel, Switzerland) 12 (11).

Rajendrasozhan, S., S.R. Yang, V.L. Kinnula, and I. Rahman. 2008. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 177 (8): 861–870.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin, Q.Q., C.F. Yan, R. Lin, J.Y. Zhang, W.R. Wang, L.N. Yang, and K.F. Zhang. 2012. SIRT1 regulates TNF-α-induced expression of CD40 in 3T3-L1 adipocytes via NF-κB pathway. Cytokine 60 (2): 447–455.

Article  CAS  PubMed  Google Scholar 

Park, S., J. Shin, J. Bae, D. Han, S.R. Park, J. Shin, S.K. Lee, and H.W. Park. 2020. SIRT1 alleviates LPS-induced IL-1β production by suppressing NLRP3 inflammasome activation and ROS production in trophoblasts. Cells 9 (3).

Arioz, B.I., B. Tastan, E. Tarakcioglu, K.U. Tufekci, M. Olcum, N. Ersoy, A. Bagriyanik, K. Genc, and S. Genc. 2019. Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1/Nrf2 pathway. Frontiers in Immunology 10: 1511.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duangjan, C., P. Rangsinth, S. Zhang, M. Wink, and T. Tencomnao. 2021. anacardium occidentale L. leaf extracts protect against glutamate/H(2)O(2)-induced oxidative toxicity and induce neurite outgrowth: The involvement of SIRT1/Nrf2 signaling pathway and teneurin 4 transmembrane protein. Frontiers in Pharmacology 12: 627738.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patruno, A., E. Costantini, A. Ferrone, M. Pesce, F. Diomede, O. Trubiani, and M. Reale. 2020. Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells. International journal of Molecular Sciences 21 (19).

Cai, H., Q. Liang, and G. Ge. 2016. Gypenoside Attenuates β Amyloid-Induced Inflammation in N9 Microglial Cells via SOCS1 Signaling. Neural plasticity 2016: 6362707.

Article  PubMed  PubMed Central  Google Scholar 

Yang, Q., H.M. Zang, T. Xing, S.F. Zhang, C. Li, Y. Zhang, Y.H. Dong, X.W. Hu, J.T. Yu, J.G. Wen, J. Jin, J. Li, R. Zhao, T.T. Ma, and X.M. Meng. 2021. Gypenoside XLIX protects against acute kidney injury by suppressing IGFBP7/IGF1R-mediated programmed cell death and inflammation. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology 85.

Article  CAS  PubMed  Google Scholar 

Hui, B., X. Hou, R. Liu, X.H. Liu, and Z. Hu. 2021. Gypenoside inhibits ox-LDL uptake and foam cell formation through enhancing Sirt1-FOXO1 mediated autophagy flux restoration. Life Sciences 264.

Article  CAS  PubMed  Google Scholar 

Alhasani, R.H., L. Biswas, A.M. Tohari, X. Zhou, J. Reilly, J.F. He, and X. Shu. 2018. Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food and Chemical Toxicology : An International Journal Published for the British Industrial Biological Research Association 112: 76–85.

Article  CAS  PubMed  Google Scholar 

Zhang, H., X. Chen, B. Zong, H. Yuan, Z. Wang, Y. Wei, X. Wang, G. Liu, J. Zhang, S. Li, G. Cheng, Y. Wang, and Y. Ma. 2018. Gypenosides improve diabetic cardiomyopathy by inhibiting ROS-mediated NLRP3 inflammasome activation. Journal of Cellular and Molecular Medicine 22 (9): 4437–4448.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan, H., J. Cui, F. Liu, W. Zhang, H. Yang, N. He, Z. Dong, and J. Dong. 2022. Malvidin protects against lipopolysaccharide-induced acute liver injury in mice via regulating Nrf2 and NLRP3 pathways and suppressing apoptosis and autophagy. European Journal of Pharmacology 933.

Article  CAS  PubMed  Google Scholar 

Schmittgen, T.D., and K.J. Livak. 2008. Analyzing real-time PCR data by the comparative C(T) method. Nature Protocols 3 (6): 1101–1108.

Article  CAS  PubMed  Google Scholar 

Li, G., C. Hu, Y. Liu, and H. Lin. 2023. Ligustilide, a novel SIRT1 agonist, alleviates lipopolysaccharide-induced acute lung injury through deacetylation of NICD. International Immunopharmacology 121.

Article  CAS  PubMed  Google Scholar 

Qiu, Y.B., B.B. Wan, G. Liu, Y.X. Wu, D. Chen, M.D. Lu, J.L. Chen, R.Q. Yu, D.Z. Chen, and Q.F. Pang. 2020. Nrf2 protects against seawater drowning-induced acute lung injury via inhibiting ferroptosis. Respiratory Research 21 (1): 232.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo, Y., H. Zhang, Z. Lv, Y. Du, D. Li, H. Fang, J. You, L. Yu, and R. Li. 2023. Up-regulated CD38 by daphnetin alleviates lipopolysaccharide-induced lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway. Cell Communication and Signaling : CCS 21 (1): 66.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng, S., J. Li, L. Li, S. Lin, Y. Yang, T. Liu, T. Zhang, G. Xie, D. Wu, and Y. Xu. 2023. Quercetin alleviates lipopolysaccharide-induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway. International Journal of Molecular Medicine 52 (6).

Ye, J., M. Guan, Y. Lu, D. Zhang, C. Li, and C. Zhou. 2019. Arbutin attenuates LPS-induced lung injury via Sirt1/ Nrf2/ NF-κBp65 pathway. Pulmonary Pharmacology & Therapeutics 54: 53–59.

Article  CAS  Google Scholar 

Han, B., S. Li, Y. Lv, D. Yang, J. Li, Q. Yang, P. Wu, Z. Lv, and Z. Zhang. 2019. Dietary melatonin attenuates chromium-induced lung injury via activating the Sirt1/Pgc-1α/Nrf2 pathway. Food & Function 10 (9): 5555–5565.

Article  CAS  Google Scholar 

Levine, B., and G. Kroemer. 2008. Autophagy in the pathogenesis of disease. Cell 132 (1): 27–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanner, M.A., X. Bu, J.A. Steimle, and P.R. Myers. 1999. The direct release of nitric oxide by gypenosides derived from the herb gynostemma pentaphyllum. Nitric Oxide : Biology and Chemistry 3 (5): 359–365.

Article  CAS  PubMed  Google Scholar 

Huang, T.H., V.H. Tran, B.D. Roufogalis, and Y. Li. 2007. Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells. Toxicology and Applied Pharmacology 218 (1): 30–36.

Article  CAS  PubMed