Latenstein AEJ, van der Geest LGM, Bonsing BA, Groot Koerkamp B, Haj Mohammad N, de Hingh I, et al. Nationwide trends in incidence, treatment and survival of pancreatic ductal adenocarcinoma. Eur J Cancer. 2020;125:83–93.

Article  CAS  PubMed  Google Scholar 

Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States. Cancer Res. 2014;74(11):2913–21.

Article  CAS  PubMed  Google Scholar 

Grossberg AJ, Chu LC, Deig CR, Fishman EK, Hwang WL, Maitra A, et al. Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma. CA Cancer J Clin. 2020;70(5):375–403.

Article  PubMed  PubMed Central  Google Scholar 

Kamisawa T, Wood LD, Itoi T, Takaori K. Pancreatic cancer. Lancet. 2016;388(10039):73–85.

Article  CAS  PubMed  Google Scholar 

Kulemann B, Hoeppner J, Wittel U, Glatz T, Keck T, Wellner UF, et al. Perioperative and long-term outcome after standard pancreaticoduodenectomy, additional portal vein and multivisceral resection for pancreatic head cancer. J Gastrointest Surg. 2015;19(3):438–44.

Article  PubMed  Google Scholar 

Gillen S, Schuster T, Meyer Zum Buschenfelde C, Friess H, Kleeff J. Preoperative/neoadjuvant therapy in pancreatic cancer: a systematic review and meta-analysis of response and resection percentages. PLoS Med. 2010;7(4):e1000267.

Article  PubMed  PubMed Central  Google Scholar 

Groot VP, Gemenetzis G, Blair AB, Rivero-Soto RJ, Yu J, Javed AA, et al. Defining and Predicting Early recurrence in 957 patients with resected pancreatic ductal adenocarcinoma. Ann Surg. 2019;269(6):1154–62.

Article  PubMed  Google Scholar 

Conroy T, Pfeiffer P, Vilgrain V, Lamarca A, Seufferlein T, O’Reilly EM et al. Pancreatic cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up. Ann Oncol. 2023.

Tong Z, Liu Y, Ma H, Zhang J, Lin B, Bao X, et al. Development, Validation and Comparison of Artificial Neural Network Models and Logistic Regression models Predicting Survival of Unresectable Pancreatic Cancer. Front Bioeng Biotechnol. 2020;8:196.

Article  PubMed  PubMed Central  Google Scholar 

Caputo D, Quagliarini E, Coppola A, La Vaccara V, Marmiroli B, Sartori B, et al. Inflammatory biomarkers and nanotechnology: new insights in pancreatic cancer early detection. Int J Surg. 2023;109(10):2934–40.

Article  PubMed  PubMed Central  Google Scholar 

Zhou T, Man Q, Li X, Xie Y, Hou X, Wang H, et al. Artificial intelligence-based comprehensive analysis of immune-stemness-tumor budding profile to predict survival of patients with pancreatic adenocarcinoma. Cancer Biol Med. 2023;20(3):196–217.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yugawa K, Maeda T, Nagata S, Sakai A, Taketani K, Yamaguchi S, et al. A novel combined carbohydrate antigen 19 – 9 and lymphocyte-to-monocyte ratio score can predict early recurrence of resectable pancreatic ductal adenocarcinoma. Surg Today. 2023;53(10):1199–208.

Article  CAS  PubMed  Google Scholar 

Chen Q, Yin H, Liu S, Shoucair S, Ding N, Ji Y et al. Prognostic value of tumor-associated N1/N2 neutrophil plasticity in patients following radical resection of pancreas ductal adenocarcinoma. J Immunother Cancer. 2022;10(12).

Nurmi AM, Mustonen H, Haglund C, Seppanen H. Changes in CRP and CA19-9 during preoperative oncological therapy predict postoperative survival in pancreatic ductal adenocarcinoma. Oncology. 2021;99(11):686–98.

Article  CAS  PubMed  Google Scholar 

Itoh S, Tsujita E, Fukuzawa K, Sugimachi K, Iguchi T, Ninomiya M, et al. Prognostic significance of preoperative PNI and CA19-9 for pancreatic ductal adenocarcinoma: a multi-institutional retrospective study. Pancreatology. 2021;21(7):1356–63.

Article  CAS  PubMed  Google Scholar 

Murakawa M, Kawahara S, Takahashi D, Kamioka Y, Yamamoto N, Kobayashi S, et al. Risk factors for early recurrence in patients with pancreatic ductal adenocarcinoma who underwent curative resection. World J Surg Oncol. 2023;21(1):263.

Article  PubMed  PubMed Central  Google Scholar 

van Wijk L, de Klein GW, Kanters MA, Patijn GA, Klaase JM. The ultimate preoperative C-reactive protein-to-albumin ratio is a prognostic factor for survival after pancreatic cancer resection. Eur J Med Res. 2020;25(1):46.

Article  PubMed  PubMed Central  Google Scholar 

Inoue D, Ozaka M, Matsuyama M, Yamada I, Takano K, Saiura A, et al. Prognostic value of neutrophil-lymphocyte ratio and level of C-reactive protein in a large cohort of pancreatic cancer patients: a retrospective study in a single institute in Japan. Jpn J Clin Oncol. 2015;45(1):61–6.

Article  PubMed  Google Scholar 

De Felice F, Cattaneo CG, Poto GE, Antropoli C, Brillantino A, Carbone L, et al. Mapping the landscape of immunonutrition and cancer research: a comprehensive bibliometric analysis on behalf of NutriOnc Research Group. Int J Surg. 2024;110(1):395–405.

Article  PubMed  Google Scholar 

Liang X, Yao S, Lu P, Ma Y, Xu H, Yin Z, et al. The Prognostic Value of New Index (LANR) composed of pre-operative lymphocytes, Albumin, and neutrophils in patients with Resectable Colorectal Cancer. Front Oncol. 2021;11:610264.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang S, Wang Y, Zhuang J, Wu Y, Shi W, Wang L. Prognostic significance of index (LANR) composed of preoperative lymphocytes, albumin, and neutrophils in patients with stage IB-IIA cervical cancer. PLoS ONE. 2023;18(9):e0290905.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chun YS, Pawlik TM, Vauthey JN. 8th Edition of the AJCC Cancer staging Manual: pancreas and hepatobiliary cancers. Ann Surg Oncol. 2018;25(4):845–7.

Article  PubMed  Google Scholar 

He M, Liu Y, Huang H, Wu J, Wu J, Wang R et al. Serum aspartate aminotransferase is an adverse prognostic indicator for patients with resectable pancreatic ductal adenocarcinoma. Lab Med. 2023.

Jablonska B, Lampe P, Mrowiec S. The influence of nutritional status on the incidence of postoperative complications in patients following distal pancreatectomy. Prz Gastroenterol. 2020;15(1):65–75.

PubMed  Google Scholar 

Hu ZI, O’Reilly EM. Therapeutic developments in pancreatic cancer. Nat Rev Gastroenterol Hepatol. 2023.

Vezakis I, Vezakis A, Gourtsoyianni S, Koutoulidis V, Polydorou AA, Matsopoulos GK et al. An Automated Prognostic Model for pancreatic ductal adenocarcinoma. Genes (Basel). 2023;14(9).

Yoon SJ, Park B, Kwon J, Lim CS, Shin YC, Jung W et al. Development of Nomograms for Predicting Prognosis of Pancreatic Cancer after Pancreatectomy: a Multicenter Study. Biomedicines. 2022;10(6).

Gu Y, Hua Q, Li Z, Zhang X, Lou C, Zhang Y, et al. Diagnostic value of combining preoperative inflammatory markers ratios with CA199 for patients with early-stage pancreatic cancer. BMC Cancer. 2023;23(1):227.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang JC, Pan B, Jiang T, Zhang XX, Lyu SC, Lang R. Effect of the preoperative prognostic nutritional index on the long-term prognosis in patients with borderline resectable pancreatic cancer after pancreaticoduodenectomy. Front Oncol. 2023;13:1098459.

Article  PubMed  PubMed Central  Google Scholar 

Sadeghi M, Keshavarz-Fathi M, Baracos V, Arends J, Mahmoudi M, Rezaei N. Cancer cachexia: diagnosis, assessment, and treatment. Crit Rev Oncol Hematol. 2018;127:91–104.

Article  PubMed  Google Scholar 

Gupta D, Lis CG. Pretreatment serum albumin as a predictor of cancer survival: a systematic review of the epidemiological literature. Nutr J. 2010;9:69.

Article  PubMed  PubMed Central  Google Scholar 

Danan D, Shonka DC Jr., Selman Y, Chow Z, Smolkin ME, Jameson MJ. Prognostic value of albumin in patients with head and neck cancer. Laryngoscope. 2016;126(7):1567–71.

Article  CAS  PubMed  Google Scholar 

Chen Z, Shao Y, Wang K, Cao W, Xiong Y, Wu R, et al. Prognostic role of pretreatment serum albumin in renal cell carcinoma: a systematic review and meta-analysis. Onco Targets Ther. 2016;9:6701–10.

Article  PubMed  PubMed Central  Google Scholar 

Lien YC, Hsieh CC, Wu YC, Hsu HS, Hsu WH, Wang LS, et al. Preoperative serum albumin level is a prognostic indicator for adenocarcinoma of the gastric cardia. J Gastrointest Surg. 2004;8(8):1041–8.

Article  PubMed  Google Scholar 

Asher V, Lee J, Bali A. Preoperative serum albumin is an independent prognostic predictor of survival in ovarian cancer. Med Oncol. 2012;29(3):2005–9.

Article  CAS  PubMed  Google Scholar 

De Luca R, Gianotti L, Pedrazzoli P, Brunetti O, Rizzo A, Sandini M, et al. Immunonutrition and prehabilitation in pancreatic cancer surgery: a new concept in the era of ERAS® and neoadjuvant treatment. Eur J Surg Oncol. 2023;49(3):542–9.

Article  PubMed  Google Scholar 

Liew PX, Kubes P. The Neutrophil’s role during Health and Disease. Physiol Rev. 2019;99(2):1223–48.

Article  CAS  PubMed  Google Scholar 

Zhang CL, Gao MQ, Jiang XC, Pan X, Zhang XY, Li Y, et al. Research progress and value of albumin-related inflammatory markers in the prognosis of non-small cell lung cancer: a review of clinical evidence. Ann Med. 2023;55(1):1294–307.

Article  PubMed  PubMed Central  Google Scholar