van den Bent MJ, Geurts M, French PJ, Smits M, Capper D, Bromberg JEC, Chang SM (2023) Primary brain tumours in adults. Lancet. 28;402(10412):1564–1579. https://doi.org/10.1016/S0140-6736(23)01054-1

Rasmussen BK, Hansen S, Laursen RJ, Kosteljanetz M, Schultz H, Nørgård BM, Guldberg R, Gradel KO (2017) Epidemiology of glioma: clinical characteristics, symptoms, and predictors of glioma patients grade I-IV in the the Danish Neuro-Oncology Registry. J Neurooncol 135(3):571–579. https://doi.org/10.1007/s11060-017-2607-5

Article  PubMed  Google Scholar 

Stupp R, Mason WP, van den Bent MJ, Weller M, Fisher B, Taphoorn MJ, Belanger K, Brandes AA, Marosi C, Bogdahn U, Curschmann J, Janzer RC, Ludwin SK, Gorlia T, Allgeier A, Lacombe D, Cairncross JG, Eisenhauer E, Mirimanoff RO, National Cancer Institute of Canada Clinical Trials Group (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352(10):987–996. https://doi.org/10.1056/NEJMoa043330

Article  CAS  PubMed  Google Scholar 

Tosoni A, Franceschi E, Poggi R, Brandes AA (2016) Relapsed glioblastoma: treatment strategies for initial and subsequent recurrences. Curr Treat Options Oncol 17(9):49. https://doi.org/10.1007/s11864-016-0422-4

Article  PubMed  Google Scholar 

Pfaff E, Kessler T, Balasubramanian GP, Berberich A, Schrimpf D, Wick A, Debus J, Unterberg A, Bendszus M, Herold-Mende C, Capper D, Schenkel I, Eisenmenger A, Dettmer S, Brors B, Platten M, Pfister SM, von Deimling A, Jones DTW, Wick W, Sahm F (2018) Feasibility of real-time molecular profiling for patients with newly diagnosed glioblastoma without MGMT promoter hypermethylation-the NCT Neuro Master Match (N2M2) pilot study. Neuro Oncol. 18;20(6):826–837. https://doi.org/10.1093/neuonc/nox216

ilf N, Kuttruff-Coqui S, Frenzel K, Bukur V, Stevanović S, Gouttefangeas C, Platten M, Tabatabai G, Dutoit V, van der Burg SH, Thor Straten P, Martínez-Ricarte F, Ponsati B, Okada H, Lassen U, Admon A, Ottensmeier CH, Ulges A, Kreiter S, von Deimling A, Skardelly M, Migliorini D, Kroep JR, Idorn M, Rodon J, Piró J, Poulsen HS, Shraibman B, McCann K, Mendrzyk R, Löwer M, Stieglbauer M, Britten CM, Capper D, Welters MJP, Sahuquillo J, Kiesel K, Derhovanessian E, Rusch E, Bunse L, Song C, Heesch S, Wagner C, Kemmer-Brück A, Ludwig J, Castle JC, Schoor O, Tadmor AD, Green E, Fritsche J, Meyer M, Pawlowski N, Dorner S, Hoffgaard F, Rössler B, Maurer D, Weinschenk T, Reinhardt C, Huber C, Rammensee HG, Singh-Jasuja H, Sahin U, Dietrich PY, Wick W (2019) Actively personalized vaccination trial for newly diagnosed glioblastoma. Nature 565(7738):240–245. https://doi.org/10.1038/s41586-018-0810-y

Article  CAS  Google Scholar 

Yang Y, Brown MC, Zhang G, Stevenson K, Mohme M, Kornahrens R, Bigner DD, Ashley DM, López GY, Gromeier M (2023) Polio virotherapy targets the malignant glioma myeloid infiltrate with diffuse microglia activation engulfing the CNS. Neuro Oncol. 5;25(9):1631–1643. https://doi.org/10.1093/neuonc/noad052

Renovanz M, Hickmann AK, Coburger J, Kohlmann K, Janko M, Reuter AK, Keric N, Nadji-Ohl M, König J, Singer S, Giese A, Hechtner M (2018) Assessing psychological and supportive care needs in glioma patients - feasibility study on the use of the supportive care needs Survey short form (SCNS-SF34-G) and the supportive care needs Survey Screening Tool (SCNS-ST9) in clinical practice. Eur J Cancer Care (Engl) 27(1). https://doi.org/10.1111/ecc.12598

Ford E, Catt S, Chalmers A, Fallowfield L (2012) Systematic review of supportive care needs in patients with primary malignant brain tumors. Neuro Oncol 14(4):392–404. https://doi.org/10.1093/neuonc/nor229

Article  PubMed  PubMed Central  Google Scholar 

Renovanz M, Gutenberg A, Haug M, Strittmatter E, Mazur J, Nadji-Ohl M, Giese A, Hopf N (2013) Postsurgical screening for psychosocial disorders in neurooncological patients. Acta Neurochir (Wien) 155(12):2255–2261. https://doi.org/10.1007/s00701-013-1884-9

Article  CAS  PubMed  Google Scholar 

Valko PO, Siddique A, Linsenmeier C, Zaugg K, Held U, Hofer S (2015) Prevalence and predictors of fatigue in glioblastoma: a prospective study. Neuro Oncol 17(2):274–281. https://doi.org/10.1093/neuonc/nou127

Article  CAS  PubMed  Google Scholar 

Litofsky NS, Farace E, Anderson F Jr, Meyers CA, Huang W, Laws ER Jr, Glioma Outcomes Project Investigators (2004) Depression in patients with high-grade glioma: results of the Glioma outcomes Project. Neurosurgery 54(2):358–366 discussion 366-7. https://doi.org/10.1227/01.neu.0000103450.94724.a2

Article  PubMed  Google Scholar 

Flechl B, Ackerl M, Sax C, Oberndorfer S, Calabek B, Sizoo E, Reijneveld J, Crevenna R, Keilani M, Gaiger A, Dieckmann K, Preusser M, Taphoorn MJ, Marosi C (2013) The caregivers’ perspective on the end-of-life phase of glioblastoma patients. J Neurooncol 112(3):403–411. https://doi.org/10.1007/s11060-013-1069-7

Article  PubMed  Google Scholar 

Walbert T (2014) Integration of palliative care into the neuro-oncology practice: patterns in the United States. Neurooncol Pract 1(1):3–7. https://doi.org/10.1093/nop/npt004

Article  PubMed  PubMed Central  Google Scholar 

Champ CE, Palmer JD, Volek JS, Werner-Wasik M, Andrews DW, Evans JJ, Glass J, Kim L, Shi W (2014) Targeting metabolism with a ketogenic diet during the treatment of glioblastoma multiforme. J Neurooncol 117(1):125–131. https://doi.org/10.1007/s11060-014-1362-0

Article  CAS  PubMed  Google Scholar 

Trogrlić I, Trogrlić D, Trogrlić D, Trogrlić AK (2018) Treatment of glioblastoma with herbal medicines. World J Surg Oncol. 13;16(1):28. https://doi.org/10.1186/s12957-018-1329-2

Onken J, Friesen C, Vajkoczy P, Misch M (2017) Safety and Tolerance of D,L-Methadone in Combination with Chemotherapy in patients with Glioma. Anticancer Res 37(3):1227–1235. https://doi.org/10.21873/anticanres.11438

Article  CAS  PubMed  Google Scholar 

NCCIH. Complementary, alternative, or integrative health: What’s in a name. (2015) [Internet]. URL: https://nccih.nih.gov/health/whatiscam

Renovanz M, Hickmann AK, Nadji-Ohl M, Keric N, Weimann E, Wirtz CR, Singer S, Ringel F, Coburger J (2020) Health-related quality of life and distress in elderly vs. younger patients with high-grade glioma-results of a multicenter study. Support Care Cancer 11:5165–5175. https://doi.org/10.1007/s00520-020-05354-8

Article  Google Scholar 

Renovanz M, Hechtner M, Janko M, Kohlmann K, Coburger J, Nadji-Ohl M, König J, Ringel F, Singer S, Hickmann AK Factors associated with supportive care needs in glioma patients in the neuro-oncological outpatient setting (2017). J Neurooncol 133(3):653–662. https://doi.org/10.1007/s11060-017-2484-y

Heese O, Schmidt M, Nickel S, Berger H, Goldbrunner R, Tonn JC, Bähr O, Steinbach JP, Simon M, Schramm J, Krex D, Schackert G, Reithmeier T, Nikkhah G, Löffler M, Weller M, Westphal M, German Glioma Network (2010) Complementary therapy use in patients with glioma: an observational study. Neurology. 14;75(24):2229-35. https://doi.org/10.1212/WNL.0b013e31820202c6

Le Rhun E, Devos P, Bourg V, Darlix A, Lorgis V, Ahle G, Boone M, Taillandier L, Curtit E, Gras L, Lebrun Frenay C, Gramatzki D, Ramirez C, Simon N, Weller M (2019) Complementary and alternative medicine use in glioma patients in France. J Neurooncol 145(3):487–499. https://doi.org/10.1007/s11060-019-03315-8

Article  CAS  PubMed  Google Scholar 

Horneber M, Bueschel G, Dennert G, Less D, Ritter E, Zwahlen M (2012) How many cancer patients use complementary and alternative medicine: a systematic review and metaanalysis. Integr Cancer Ther 11(3):187–203. https://doi.org/10.1177/1534735411423920

Article  PubMed  Google Scholar 

Eisele G, Roelcke U, Conen K, Huber F, Weiss T, Hofer S, Heese O, Westphal M, Hertler C, Roth P, Weller M (2019) Complementary and alternative medicine use by glioma patients in Switzerland. Neurooncol Pract 6(3):237–244. https://doi.org/10.1093/nop/npy035

Article  PubMed  Google Scholar 

Mulpur BH, Nabors LB, Thompson RC, Olson JJ, LaRocca RV, Thompson Z, Egan KM (2015) Complementary therapy and survival in glioblastoma. Neurooncol Pract 2(3):122–126. https://doi.org/10.1093/nop/npv008

Article  PubMed  PubMed Central  Google Scholar 

Chow WH, Chang P, Lee SC, Wong A, Shen HM, Verkooijen HM (2010) Complementary and alternative medicine among Singapore cancer patients. Ann Acad Med Singap 39(2):129–135

Article  PubMed  Google Scholar 

Raimund F, Nickel S, Hessler C, Regelsberger J, Westphal M, Heese O (2011) Non-conventional treatments sought by patients after surgery for intramedullary spinal cord tumors. Cent Eur Neurosurg 72(2):71–74. https://doi.org/10.1055/s-0030-1252009Epub 2010 May 21. PMID: 20496309

Article  CAS  PubMed  Google Scholar 

Magi T, Kuehni CE, Torchetti L, Wengenroth L, Lüer S, Frei-Erb M (2015) Use of Complementary and Alternative Medicine in Children with Cancer: A Study at a Swiss University Hospital. PLoS One. 22;10(12):e0145787. https://doi.org/10.1371/journal.pone.0145787

Mao JJ, Palmer CS, Healy KE, Desai K, Amsterdam J (2011) Complementary and alternative medicine use among cancer survivors: a population-based study. J Cancer Surviv 5(1):8–17. https://doi.org/10.1007/s11764-010-0153-7

Article  PubMed  Google Scholar 

Firkins R, Eisfeld H, Keinki C, Buentzel J, Hochhaus A, Schmidt T, Huebner J (2018) The use of complementary and alternative medicine by patients in routine care and the risk of interactions. J Cancer Res Clin Oncol 144(3):551–557. https://doi.org/10.1007/s00432-018-2587-7

Article  CAS  PubMed  Google Scholar 

Armstrong T, Cohen MZ, Hess KR, Manning R, Lee EL, Tamayo G, Baumgartner K, Min SJ, Yung A, Gilbert M (2006) Complementary and alternative medicine use and quality of life in patients with primary brain tumors. J Pain Symptom Manage 32(2):148–154. https://doi.org/10.1016/j.jpainsymman.2006.02.015

Article  PubMed  Google Scholar 

Rudolph I, Seilacher E, Köster MJ, Stellamanns J, Liebl P, Zell J, Ludwig S, Beck V, Hübner J (2015) Der Informationsbedarf von Patienten mit Krebserkrankungen in Deutschland - eine Befragung von Patienten und Angehörigen [Survey on information needs of cancer patients and their relatives in Germany]. Dtsch Med Wochenschr. 140(5):e43-7. German. https://doi.org/10.1055/s-0041-100585

Eng K, Feeny D (2007) Comparing the health of low income and less well educated groups in the United States and Canada. Popul Health Metr 16:5:10. https://doi.org/10.1186/1478-7954-5-10

Article  Google Scholar 

Eidinger RN, Schapira DV (1984) Cancer patients’ insight into their treatment, prognosis, and unconventional therapies. Cancer. 15;53(12):2736-40. https://doi.org/10.1002/1097-0142(19840615)53:12<2736::aid-cncr2820531233>3.0.co;2-w

King N, Balneaves LG, Levin GT, Nguyen T, Nation JG, Card C, Truant T, Carlson LE (2015) Surveys of Cancer patients and Cancer Health Care Providers regarding complementary therapy Use, Communication, and Information needs. Integr Cancer Ther 6515–524. https://doi.org/10.1177/1534735415589984

Halkett GK, Lobb EA, Oldham L, Nowak AK (2010) The information and support needs of patients diagnosed with high Grade Glioma. Patient Educ Couns 79(1):112–119. https://doi.org/10.1016/j.pec.2009.08.013

Article  PubMed  Google Scholar 

Al-Lawati H, Al-Baimani K, Al-Zadjali M, Al-Obaidani N, Al-Kiyumi Z, Al-Khabori MK (2018) Knowledge and attitudes towards clinical trial participation in Oman: a cross-sectional study. Sultan Qaboos Univ Med J 18(1):e54–e60. https://doi.org/10.18295/squmj.2018.18.01.009

Article  PubMed  PubMed Central  Google Scholar 

Wallington SF, Luta G, Noone AM, Caicedo L, Lopez-Class M, Sheppard V, Spencer C, Mandelblatt J (2012) Assessing the awareness of and willingness to participate in cancer clinical trials among immigrant latinos. J Community Health 37(2):335–343. https://doi.org/10.1007/s10900-011-9450-y

Article  PubMed  PubMed Central  Google Scholar 

Lee SJ, Park LC, Lee J, Kim S, Choi MK, Hong JY, Park S, Maeng CH, Chang W, Kim YS, Park SH, Park JO, Lim HY, Kang WK, Park YS (2012) Unique perception of clinical trials by Korean cancer patients. BMC Cancer 12(12):594. https://doi.org/10.1186/1471-2407-12-594

Article  PubMed  PubMed Central  Google Scholar 

Jenkins V, Farewell D, Batt L, Maughan T, Branston L, Langridge C, Parlour L, Farewell V, Fallowfield L (2010) The attitudes of 1066 patients with cancer towards participation in randomised clinical trials. Br J Cancer. 7;103(12):1801-7. https://doi.org/10.1038/sj.bjc.6606004

Ruetters D, Keinki C, Schroth S, Liebl P, Huebner J (2015) Is there evidence for a better health care for cancer patients after a second opinion? A systematic review. J Cancer Res Clin Oncol 142(7):1521–1528. https://doi.org/10.1007/s00432-015-2099-7

Article