1Department of Medicine and Cell Physiology and Metabolism, University of Geneva, Geneva, Switzerland

2Institute of Anatomy, University of Zurich, Zurich, Switzerland

3Laboratories for Translational Research, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.

4Department of Medicine, Division of Nephrology, Ente Ospedaliero Cantonale, Lugano, Switzerland.

5Division of Intensive Care, Department of Acute Medicine, University Hospital of Geneva, Geneva, Switzerland.

6Istituto Dalle Molle di Studi sull'Intelligenza Artificiale (IDSIA), USI/SUPSI, Lugano, Switzerland,

7Department of Medicine, Service of Nephrology, Geneva University Hospitals, Geneva, Switzerland.

8Department of Nephrology, University Hospital Zurich, Zurich, Switzerland.

9Zurich Kidney Center, Zurich, Switzerland.

aAddress for submission correspondence: Andrew Hall MD PhD Institute of Anatomy University of Zurich Winterthurerstrasse 190 8057 Zurich Switzerland Email: [email protected] Tel: +41 (0)44 635 52 25 Fax: +41 (0)44 635 57 02

*Denotes contributed equally.