Johnson DE, Burtness B, Leemans CR, Lui VWY, Bauman JE, Grandis JR. Head and neck squamous cell carcinoma. Nat Rev Dis Primers. 2020;6(1):92.

Article  PubMed  Google Scholar 

Turculeanu A, Mogoanta CA, Ionita E, Avramescu CS, Afrem MC, Costache A. TNF-α evaluation in tonsil cancer. Rom J Morphol Embryol. 2015;56(1):101–6.

PubMed  Google Scholar 

Bhatia KS, King AD, Yeung DK, Mo F, Vlantis AC, Yu KH, et al. Can diffusion-weighted imaging distinguish between normal and squamous cell carcinoma of the palatine tonsil? Br J Radiol. 2010;83(993):753–8.

Article  CAS  PubMed  Google Scholar 

Kim TY, Lee JY, Lee YJ, Park DW, Tae K, Choi YY. CT texture analysis of tonsil cancer: Discrimination from normal palatine tonsils. PLoS ONE. 2021;16(8):e0255835.

Article  CAS  PubMed  Google Scholar 

Lee JR, Kim JS, Roh JL, Lee JH, Baek JH, Cho KJ, et al. Detection of Occult Primary Tumors in Patients with Cervical Metastases of Unknown Primary Tumors: Comparison of <SUP>18</SUP>F FDG PET/CT with Contrast-enhanced CT or CT/MR Imaging-Prospective Study. Radiology. 2015;274(3):764–71.

Article  PubMed  Google Scholar 

Creff G, Devillers A, Depeursinge A, Palard-Novello X, Acosta O, Jegoux F, et al. Evaluation of the Prognostic Value of FDG PET/CT Parameters for Patients With Surgically Treated Head and Neck Cancer: A Systematic Review. JAMA Otolaryngol Head Neck Surg. 2020;146(5):471–9.

Article  PubMed  Google Scholar 

Al-Ibraheem A, Abdlkadir AS, Shagera QA, Saraireh O, Al-Adhami D, Al-Rashdan R, et al. The Diagnostic and Predictive Value of (18)F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Laryngeal Squamous Cell Carcinoma. Cancers (Basel). 2023;15(22):5461.

Article  CAS  PubMed  Google Scholar 

Horváth A, Prekopp P, Polony G, Székely E, Tamás L, Dános K. Accuracy of the preoperative diagnostic workup in patients with head and neck cancers undergoing neck dissection in terms of nodal metastases. Eur Arch Otorhinolaryngol. 2021;278(6):2041–6.

Article  PubMed  Google Scholar 

Kuntz AL, Weymuller EA Jr. Impact of neck dissection on quality of life. Laryngoscope. 1999;109(8):1334–8.

Article  CAS  PubMed  Google Scholar 

Moy J, Li R. Approach to the Patient with Unknown Primary Squamous Cell Carcinoma of the Head and Neck. Curr Treat Options Oncol. 2020;21(12):93.

Article  PubMed  Google Scholar 

Nguyen A, Luginbuhl A, Cognetti D, Van Abel K, Bar-Ad V, Intenzo C, et al. Effectiveness of PET/CT in the preoperative evaluation of neck disease. Laryngoscope. 2014;124(1):159–64.

Article  PubMed  Google Scholar 

Anderson J, Paterek E. Tonsillitis. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2024, StatPearls Publishing LLC.; 2024.

Kawabe J, Okamura T, Shakudo M, Koyama K, Wanibuchi H, Sakamoto H, et al. Two cases of chronic tonsillitis studied by FDG-PET. Ann Nucl Med. 1999;13(4):277–9.

Article  CAS  PubMed  Google Scholar 

Cianchetti M, Mancuso AA, Amdur RJ, Werning JW, Kirwan J, Morris CG, et al. Diagnostic evaluation of squamous cell carcinoma metastatic to cervical lymph nodes from an unknown head and neck primary site. Laryngoscope. 2009;119(12):2348–54.

Article  PubMed  Google Scholar 

Nakamoto Y, Tatsumi M, Hammoud D, Cohade C, Osman MM, Wahl RL. Normal FDG distribution patterns in the head and neck: PET/CT evaluation. Radiology. 2005;234(3):879–85.

Article  PubMed  Google Scholar 

Rosenbaum SJ, Lind T, Antoch G, Bockisch A. False-positive FDG PET uptake–the role of PET/CT. Eur Radiol. 2006;16(5):1054–65.

Article  PubMed  Google Scholar 

Rusthoven KE, Koshy M, Paulino AC. The role of fluorodeoxyglucose positron emission tomography in cervical lymph node metastases from an unknown primary tumor. Cancer. 2004;101(11):2641–9.

Article  PubMed  Google Scholar 

Park JE, Lenter MC, Zimmermann RN, Garin-Chesa P, Old LJ, Rettig WJ. Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts. J Biol Chem. 1999;274(51):36505–12.

Article  CAS  PubMed  Google Scholar 

Zhao L, Chen J, Pang Y, Fu K, Shang Q, Wu H, et al. Fibroblast activation protein-based theranostics in cancer research: a state-of-the-art review. Theranostics. 2022;12(4):1557–69.

Article  CAS  PubMed  Google Scholar 

Lindner T, Loktev A, Altmann A, Giesel F, Kratochwil C, Debus J, et al. Development of Quinoline-Based Theranostic Ligands for the Targeting of Fibroblast Activation Protein. J Nucl Med. 2018;59(9):1415–22.

Article  CAS  PubMed  Google Scholar 

Serfling S, Zhi Y, Schirbel A, Lindner T, Meyer T, Gerhard-Hartmann E, et al. Improved cancer detection in Waldeyer’s tonsillar ring by (68)Ga-FAPI PET/CT imaging. Eur J Nucl Med Mol Imaging. 2021;48(4):1178–87.

Article  CAS  PubMed  Google Scholar 

Al-Ibraheem A, Alyasjeen SF, Abdlkadir AS, Sheikha AA. [(68)Ga]Ga-DOTA-FAPI-04 PET/CT depicts metastases from medullary thyroid cancer that [(68)Ga]Ga-DOTATOC PET/CT missed. Eur J Nucl Med Mol Imaging. 2023;50(13):4112–3.

Article  CAS  PubMed  Google Scholar 

Kratochwil C, Flechsig P, Lindner T, Abderrahim L, Altmann A, Mier W, et al. (68)Ga-FAPI PET/CT: Tracer Uptake in 28 Different Kinds of Cancer. J Nucl Med. 2019;60(6):801–5.

Article  CAS  PubMed  Google Scholar 

Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin. 2017;67(2):122–37.

Article  PubMed  Google Scholar 

Quon A, Fischbein NJ, McDougall IR, Le QT, Loo BW Jr, Pinto H, et al. Clinical role of 18F-FDG PET/CT in the management of squamous cell carcinoma of the head and neck and thyroid carcinoma. J Nucl Med. 2007;48(Suppl 1):58s–67s.

CAS  PubMed  Google Scholar 

Jiang Y, Wen B, Li C, Tian Y, Xiao Z, Xu K, et al. The performance of (68)Ga-FAPI-04 PET/CT in head and neck squamous cell carcinoma: a prospective comparison with (18)F-FDG PET/CT. Eur J Nucl Med Mol Imaging. 2023;50(7):2114–26.

Article  CAS  PubMed  Google Scholar 

Promteangtrong C, Siripongsatian D, Jantarato A, Kunawudhi A, Kiatkittikul P, Yaset S, et al. Head-to-Head Comparison of (68)Ga-FAPI-46 and (18)F-FDG PET/CT for Evaluation of Head and Neck Squamous Cell Carcinoma: A Single-Center Exploratory Study. J Nucl Med. 2022;63(8):1155–61.

Article  CAS  PubMed  Google Scholar 

Chen S, Chen Z, Zou G, Zheng S, Zheng K, Zhang J, et al. Accurate preoperative staging with [(68)Ga]Ga-FAPI PET/CT for patients with oral squamous cell carcinoma: a comparison to 2-[(18)F]FDG PET/CT. Eur Radiol. 2022;32(9):6070–9.

Article  CAS  PubMed  Google Scholar 

Guglielmo P, Alongi P, Baratto L, Abenavoli E, Buschiazzo A, Celesti G, et al. Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature. Life (Basel). 2023;13(9):1821.

CAS  PubMed  Google Scholar 

Windfuhr JP, Alizoti P, Hendricks C. Regional variability of hemorrhage following tonsil surgery in 1,520,234 cases. Eur Arch Otorhinolaryngol. 2020;277(11):3169–77.

Article  PubMed  Google Scholar 

Zheng J, Liu F, Lin K, Zhang L, Huang N, Zheng W, et al. [(68)Ga]Ga-FAPI PET/CT Improves the T Staging of Patients with Newly Diagnosed Nasopharyngeal Carcinoma: A Comparison with [(18)F]F-FDG. Mol Imaging Biol. 2022;24(6):973–85.

Article  CAS  PubMed  Google Scholar 

Fu H, Wu J, Huang J, Sun L, Wu H, Guo W, et al. (68)Ga Fibroblast Activation Protein Inhibitor PET/CT in the Detection of Metastatic Thyroid Cancer: Comparison with (18)F-FDG PET/CT. Radiology. 2022;304(2):397–405.

Article  PubMed  Google Scholar 

Linz C, Brands RC, Herterich T, Hartmann S, Müller-Richter U, Kübler AC, et al. Accuracy of 18-F Fluorodeoxyglucose Positron Emission Tomographic/Computed Tomographic Imaging in Primary Staging of Squamous Cell Carcinoma of the Oral Cavity. JAMA Netw Open. 2021;4(4):e217083.

Article  PubMed  Google Scholar 

Ng SH, Yen TC, Liao CT, Chang JT, Chan SC, Ko SF, et al. 18F-FDG PET and CT/MRI in oral cavity squamous cell carcinoma: a prospective study of 124 patients with histologic correlation. J Nucl Med. 2005;46(7):1136–43.

PubMed  Google Scholar 

Lin P, Min M, Lee M, Holloway L, Forstner D, Bray V, et al. Nodal parameters of FDG PET/CT performed during radiotherapy for locally advanced mucosal primary head and neck squamous cell carcinoma can predict treatment outcomes: SUVmean and response rate are useful imaging biomarkers. Eur J Nucl Med Mol Imaging. 2017;44(5):801–11.

Article  CAS  PubMed  Google Scholar 

Min M, Lin P, Lee MT, Shon IH, Lin M, Forstner D, et al. Prognostic role of metabolic parameters of (18)F-FDG PET-CT scan performed during radiation therapy in locally advanced head and neck squamous cell carcinoma. Eur J Nucl Med Mol Imaging. 2015;42(13):1984–94.

Article  CAS  PubMed  Google Scholar 

Zhang L, Yang L, Xia ZW, Yang SC, Li WH, Liu B, et al. The role of fibroblast activation protein in progression and development of osteosarcoma cells. Clin Exp Med. 2020;20(1):121–30.

Article  CAS  PubMed  Google Scholar 

Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Dahlgren LO, Joneberg J, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int J Cancer. 2006;119(11):2620–3.

Article  CAS