Organocatalytic asymmetric [3+3] cycloaddition underpins the efficient synthesis of chiral six-membered (hetero)cyclic compounds. Various elegant works were exploited to promote the prosperity of this cycloaddition-based methodologies in the past decades. The advantage of this unique strategy lies in great compatibility with flexible catalytic modes and multiple three-atom building blocks. This review summarized the development of organocatalytic asymmetric [3+3] cycloaddition over the past twenty years. Both mechanism study and activation mode of various organocatalytic systems, including (1) chiral amine catalysis, (2) chiral bifunctional catalyst catalysis, (3) chiral N-heterocyclic carbene catalysis, (4) chiral phosphoric acid catalysis, and (5) other asymmetric organocatalysis (isothioureas, phosphine and cooperative catalysis) were discussed in this review. Additionally, in each catalytic pattern, three-atom building blocks for organocatalytic asymmetric [3+3] cycloaddition were classified into all-carbon three-atom, aza- three-atom, oxa-three-atom building blocks and those containing other heteroatoms. This review has not only given a systematic summarization on this topic, but also provided insights on the remaining challenges, which will promote the future development of this field.

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