Granzyme serine proteases in inflammation and rheumatic diseases

Joeckel, L. T. & Bird, P. I. Are all granzymes cytotoxic in vivo? Biol. Chem. 395, 181–202 (2014).

Article  CAS  PubMed  Google Scholar 

Voskoboinik, I., Whisstock, J. C. & Trapani, J. A. Perforin and granzymes: function, dysfunction and human pathology. Nat. Rev. Immunol. 15, 388–400 (2015).

Article  CAS  PubMed  Google Scholar 

Cullen, S. P., Adrain, C., Lüthi, A. U., Duriez, P. J. & Martin, S. J. Human and murine granzyme B exhibit divergent substrate preferences. J. Cell Biol. 176, 435–444 (2007).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Kaiserman, D. et al. The major human and mouse granzymes are structurally and functionally divergent. J. Cell Biol. 175, 619–630 (2006).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Pardo, J. et al. Granzyme B-induced cell death exerted by ex vivo CTL: discriminating requirements for cell death and some of its signs. Cell Death Differ. 15, 567–579 (2008).

Article  CAS  PubMed  Google Scholar 

Thomas, D. A., Scorrano, L., Putcha, G. V., Korsmeyer, S. J. & Ley, T. J. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proc. Natl Acad. Sci. USA 98, 14985–14990 (2001).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Sánchez-Martínez, D. et al. Human NK cells activated by EBV+ lymphoblastoid cells overcome anti-apoptotic mechanisms of drug resistance in haematological cancer cells. Oncoimmunology 4, e991613 (2015).

Article  PubMed Central  PubMed  Google Scholar 

Plasman, K., Demol, H., Bird, P. I., Gevaert, K. & Van Damme, P. Substrate specificities of the granzyme tryptases A and K. J. Proteome Res. 13, 6067–6077 (2014).

Article  CAS  PubMed  Google Scholar 

Plasman, K. et al. Conservation of the extended substrate specificity profiles among homologous granzymes across species. Mol. Cell Proteom. 12, 2921–2934 (2013).

Article  CAS  Google Scholar 

Garzón-Tituaña, M. et al. Granzyme A inhibition reduces inflammation and increases survival during abdominal sepsis. Theranostics 11, 3781–3795 (2021).

Article  PubMed Central  PubMed  Google Scholar 

Metkar, S. S. et al. Human and mouse granzyme A induce a proinflammatory cytokine response. Immunity 29, 720–733 (2008).

Article  CAS  PubMed  Google Scholar 

Hagn, M. et al. Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21. J. Immunol. 183, 1838–1845 (2009).

Article  CAS  PubMed  Google Scholar 

Hink-Schauer, C., Estébanez-Perpiñá, E., Kurschus, F. C., Bode, W. & Jenne, D. E. Crystal structure of the apoptosis-inducing human granzyme A dimer. Nat. Struct. Biol. 10, 535–540 (2003).

Article  CAS  PubMed  Google Scholar 

Bell, J. K. et al. The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity. Nat. Struct. Biol. 10, 527–534 (2003).

Article  CAS  PubMed  Google Scholar 

Lieberman, J. Granzyme A activates another way to die. Immunol. Rev. 235, 93–104 (2010).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Pardo, J. et al. The biology of cytotoxic cell granule exocytosis pathway: granzymes have evolved to induce cell death and inflammation. Microbes Infect. 11, 452–459 (2009).

Article  CAS  PubMed  Google Scholar 

Beresford, P. J. et al. Granzyme A activates an endoplasmic reticulum-associated caspase-independent nuclease to induce single-stranded DNA nicks. J. Biol. Chem. 276, 43285–43293 (2001).

Article  CAS  PubMed  Google Scholar 

Zhou, Z. et al. Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells. Science 368, eaaz7548 (2020).

Article  CAS  PubMed  Google Scholar 

Liu, X., Xia, S., Zhang, Z., Wu, H. & Lieberman, J. Channelling inflammation: gasdermins in physiology and disease. Nat. Rev. Drug Discov. 20, 384–405 (2021).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Isaaz, S., Baetz, K., Olsen, K., Podack, E. & Griffiths, G. M. Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway. Eur. J. Immunol. 25, 1071–1079 (1995).

Article  CAS  PubMed  Google Scholar 

Nakamura, K., Arahata, K., Ishiura, S., Osame, M. & Sugita, H. Degradative activity of granzyme A on skeletal muscle proteins in vitro: a possible molecular mechanism for muscle fiber damage in polymyositis. Neuromuscul. Dis. 3, 303–310 (1993).

Article  CAS  Google Scholar 

Campbell, R. A. et al. Granzyme A in human platelets regulates the synthesis of proinflammatory cytokines by monocytes in aging. J. Immunol. 200, 295–304 (2018).

Article  CAS  PubMed  Google Scholar 

Arias, M. A. et al. Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis. Cell Rep. 8, 420–429 (2014).

Article  CAS  PubMed  Google Scholar 

Santiago, L. et al. Extracellular granzyme A promotes colorectal cancer development by enhancing gut inflammation. Cell Rep. 32, 107847 (2020).

Article  CAS  PubMed  Google Scholar 

Santiago, L. et al. Granzyme A contributes to inflammatory arthritis in mice through stimulation of osteoclastogenesis. Arthritis Rheumatol. 69, 320–334 (2017).

Article  CAS  PubMed  Google Scholar 

Masson, D. & Tschopp, J. Inhibition of lymphocyte protease granzyme A by antithrombin III. Mol. Immunol. 25, 1283–1289 (1988).

Article  CAS  PubMed  Google Scholar 

Simon, M. M., Tran, T., Fruth, U., Gurwitz, D. & Kramer, M. D. Regulation of mouse T cell associated serine proteinase-1 (MTSP-1) by proteinase inhibitors and sulfated polysaccharides. Biol. Chem. Hoppe Seyler 371, 81–87 (1990).

CAS  PubMed  Google Scholar 

Kaiserman, D. et al. Identification of serpinb6b as a species-specific mouse granzyme A inhibitor suggests functional divergence between human and mouse granzyme A. J. Biol. Chem. 289, 9408–9417 (2014).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Aybay, E. et al. Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity. Front. Immunol. 14, 1211295 (2023).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Boivin, W. A., Cooper, D. M., Hiebert, P. R. & Granville, D. J. Intracellular versus extracellular granzyme B in immunity and disease: challenging the dogma. Lab. Invest. 89, 1195–1220 (2009).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Thornberry, N. A. et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B: functional relationships established for key mediators of apoptosis. J. Biol. Chem. 272, 17907–17911 (1997).

Article  CAS  PubMed  Google Scholar 

Zhang, Z. et al. Gasdermin E suppresses tumour growth by activating anti-tumour immunity. Nature 579, 415–420 (2020).

Article  CAS  PubMed Central  PubMed  Google Scholar 

Aubert, A., Lane, M., Jung, K. & Granville, D. J. Granzyme B as a therapeutic target: an update in 2022. Expert Opin. Ther. Targets 26, 979–993 (2022).

Article  CAS  PubMed  Google Scholar 

Richardson, K. C., Jung, K., Pardo, J., Turner, C. T. & Granville, D. J. Noncytotoxic roles of granzymes in health and disease. Physiology 37, 323–348 (2022).

Article  CAS  PubMed  Google Scholar 

Prakash, M. D., Bird, C. H. & Bird, P. I. Active and zymogen forms of granzyme B are constitutively released from cytotoxic lymphocytes in the absence of target cell engagement. Immunol. Cell Biol. 87, 249–254 (2009).

Article  CAS  PubMed  Google Scholar 

Jung, K., Pawluk, M. A., Lane, M., Nabai, L. & Granville, D. J. Granzyme B in epithelial barrier dysfunction and related skin diseases. Am. J. Physiol. Cell Physiol. 323, C170–c189 (2022).

Article  CAS  PubMed  Google Scholar 

留言 (0)

沒有登入
gif