O’Doherty J, Kringelbach ML, Rolls ET, Hornak J, Andrews C. Abstract reward and punishment representations in the human orbitofrontal cortex. Nat Neurosci. 2001;4:95–102.

Article  PubMed  Google Scholar 

Franklin TR, Acton PD, Maldjian JA, Gray JD, Croft JR, Dackis CA, et al. Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. Biol Psychiatry. 2002;51:134–42.

Article  CAS  PubMed  Google Scholar 

Bariselli S, Miyazaki NL, Creed MC, Kravitz AV. Orbitofrontal-striatal potentiation underlies cocaine-induced hyperactivity. Nat Commun. 2020;11:3996.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harada M, Pascoli V, Hiver A, Flakowski J, Luscher C. Corticostriatal activity driving compulsive reward seeking. Biol Psychiatry. 2021;90:808–18.

Article  PubMed  Google Scholar 

Xue AM, Foerde K, Walsh BT, Steinglass JE, Shohamy D, Bakkour A. Neural representations of food-related attributes in the human orbitofrontal cortex during choice deliberation in Anorexia Nervosa. J Neurosci. 2022;42:109–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakao T, Okada K, Kanba S. Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin Neurosci. 2014;68:587–605.

Article  PubMed  Google Scholar 

Pfeffer CK, Xue M, He M, Huang ZJ, Scanziani M. Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons. Nat Neurosci. 2013;16:1068–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campagnola L, Seeman SC, Chartrand T, Kim L, Hoggarth A, Gamlin C, et al. Local connectivity and synaptic dynamics in mouse and human neocortex. Science. 2022;375:eabj5861.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Jeong HY, Tremblay R, Rudy B. Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4. Neuron. 2013;77:155–67.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang W, Zhang L, Liang B, Schroeder D, Zhang ZW, Cox GA, et al. Hyperactive somatostatin interneurons contribute to excitotoxicity in neurodegenerative disorders. Nat Neurosci. 2016;19:557–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu H, Liu L, Tian Y, Wang J, Li J, Zheng J, et al. A disinhibitory microcircuit mediates conditioned social fear in the prefrontal cortex. Neuron. 2019;102:668–682.e665.

Article  CAS  PubMed  Google Scholar 

Zhang W, Daly KM, Liang B, Zhang L, Li X, Li Y, et al. BDNF rescues prefrontal dysfunction elicited by pyramidal neuron-specific DTNBP1 deletion in vivo. J Mol Cell Biol. 2017;9:117–31.

Article  CAS  PubMed  Google Scholar 

Rothman JS, Silver RA. NeuroMatic: an integrated open-source software toolkit for acquisition, analysis and simulation of electrophysiological data. Front Neuroinform. 2018;12:14.

Article  PubMed  PubMed Central  Google Scholar 

Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, et al. Fiji: an open-source platform for biological-image analysis. Nat Methods. 2012;9:676–82.

Article  CAS  PubMed  Google Scholar 

Nentwig TB, Obray JD, Vaughan DT, Chandler LJ. Behavioral and slice electrophysiological assessment of DREADD ligand, deschloroclozapine (DCZ) in rats. Sci Rep. 2022;12:6595.

Article  PubMed  PubMed Central  Google Scholar 

Nagai Y, Miyakawa N, Takuwa H, Hori Y, Oyama K, Ji B, et al. Deschloroclozapine, a potent and selective chemogenetic actuator enables rapid neuronal and behavioral modulations in mice and monkeys. Nat Neurosci. 2020;23:1157–67.

Article  CAS  PubMed  Google Scholar 

Cummings KA, Clem RL. Prefrontal somatostatin interneurons encode fear memory. Nat Neurosci. 2020;23:61–74.

Article  CAS  PubMed  Google Scholar 

Dao NC, Brockway DF, Suresh Nair M, Sicher AR, Crowley NA. Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice. Neuropsychopharmacology. 2021;46:1906–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang C, Wang X, Le Q, Liu P, Liu C, Wang Z, et al. Morphine coordinates SST and PV interneurons in the prelimbic cortex to disinhibit pyramidal neurons and enhance reward. Mol Psychiatry. 2021;26:1178–93.

Article  CAS  PubMed  Google Scholar 

Koppe G, Bruckner G, Brauer K, Hartig W, Bigl V. Developmental patterns of proteoglycan-containing extracellular matrix in perineuronal nets and neuropil of the postnatal rat brain. Cell Tissue Res. 1997;288:33–41.

Article  CAS  PubMed  Google Scholar 

Bukalo O, Schachner M, Dityatev A. Hippocampal metaplasticity induced by deficiency in the extracellular matrix glycoprotein tenascin-R. J Neurosci. 2007;27:6019–28.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Faissner A, Pyka M, Geissler M, Sobik T, Frischknecht R, Gundelfinger ED, et al. Contributions of astrocytes to synapse formation and maturation—potential functions of the perisynaptic extracellular matrix. Brain Res. Rev. 2010;63:26–38.

Article  CAS  PubMed  Google Scholar 

Miyata S, Komatsu Y, Yoshimura Y, Taya C, Kitagawa H. Persistent cortical plasticity by upregulation of chondroitin 6-sulfation. Nat. Neurosci. 2012;15:414–22. s411-412

Article  CAS  PubMed  Google Scholar 

Sigal YM, Bae H, Bogart LJ, Hensch TK, Zhuang X. Structural maturation of cortical perineuronal nets and their perforating synapses revealed by superresolution imaging. Proc Natl Acad Sci USA. 2019;116:7071–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gottschling C, Wegrzyn D, Denecke B, Faissner A. Elimination of the four extracellular matrix molecules tenascin-C, tenascin-R, brevican and neurocan alters the ratio of excitatory and inhibitory synapses. Sci Rep. 2019;9:13939.

Article  PubMed  PubMed Central  Google Scholar 

Xue YX, Xue LF, Liu JF, He J, Deng JH, Sun SC, et al. Depletion of perineuronal nets in the amygdala to enhance the erasure of drug memories. J Neurosci. 2014;34:6647–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu Z, Han Y, Hu D, Chen N, Zhang Z, Chen W, et al. Neurocan regulates vulnerability to stress and the anti-depressant effect of ketamine in adolescent rats. Mol Psychiatry. 2022;27:2522–32.

Article  CAS  PubMed  Google Scholar 

Favuzzi E, Marques-Smith A, Deogracias R, Winterflood CM, Sanchez-Aguilera A, Mantoan L, et al. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. Neuron. 2017;95:639–655 e610.

Article  CAS  PubMed  Google Scholar 

Fawcett JW, Oohashi T, Pizzorusso T. The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function. Nat Rev Neurosci. 2019;20:451–65.

Article  CAS  PubMed  Google Scholar 

Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C, et al. Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage. 2003;19:1085–94.

Article  CAS  PubMed  Google Scholar 

Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

Article  PubMed  Google Scholar 

Volkow ND, Fowler JS. Addiction, a disease of compulsion and drive: involvement of the orbitofrontal cortex. Cereb Cortex. 2000;10:318–25.

Article  CAS  PubMed  Google Scholar 

Schoenbaum G, Saddoris MP, Ramus SJ, Shaham Y, Setlow B. Cocaine-experienced rats exhibit learning deficits in a task sensitive to orbitofrontal cortex lesions. Eur J Neurosci. 2004;19:1997–2002.

Article  PubMed  Google Scholar 

Schoenbaum G, Shaham Y. The role of orbitofrontal cortex in drug addiction: a review of preclinical studies. Biol Psychiatry. 2008;63:256–62.

Article  CAS  PubMed  Google Scholar 

Chen Y, Wang G, Zhang W, Han Y, Zhang L, Xu H, et al. An orbitofrontal cortex-anterior insular cortex circuit gates compulsive cocaine use. Sci Adv. 2022;8:eabq5745.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Simmler LD, Van Zessen R, Flakowski J, Wan JX, Deng F, et al. Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science. 2021;373:1252–6.