Broad-spectrum activity of membranolytic cationic macrocyclic peptides against multi-drug resistant bacteria and fungi

Keywords

Antimicrobial peptides

Antibiotics

Bacteria

Antifungal peptides

Cyclic peptides

Drug resistance

Peptide-membrane interactions

Membranolytic

Molecular dynamics

Molecular hydrophobicity potential

AbbreviationsDAPI

4′,6-diamidino-2-phenylindole

DIC

N,N-diisopropylcarbodiimide

DOPC

diolylphosphatidylcholine

DOPG

diolylphosphatidylglycerol

HOBt

1-hydroxybenzotriazole

LUVs

large unilamellar vesicles

MHP

molecular hydrophobicity potential

RMSD

root mean square deviation

TFE

2,2,2-trifluoroethanol

XTT

2, 3-bis-(2‑methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide

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