Siegel RL, Miller KD, Jemal A. Cancer statistics, 2017. CA Cancer J Clin. 2017;67:7–30.
Zarour LR, Anand S, Billingsley KG, Bisson WH, Cercek A, Clarke MF, et al. Colorectal cancer liver metastasis: evolving paradigms and future directions. Cell Mol Gastroenterol Hepatol 2017;3:163–73.
Article PubMed PubMed Central Google Scholar
Manfredi S, Lepage C, Hatem C, Coatmeyr O, Faivre J, Bouvier A. Epidemiology and management of liver metastases from colorectal cancer. Ann Surg 2006;244:254–9.
Article PubMed PubMed Central Google Scholar
Leith JT, Padfield G, Faulkner L, Michelson S. Hypoxic fractions in xenografted human colon tumors. Cancer Res. 1991;51:5139–43.
Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 2012;148:399–408.
Article CAS PubMed PubMed Central Google Scholar
Thiery JP, Acloque H, Huang RYJ, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139:871–90.
Article CAS PubMed Google Scholar
De Bock K, Mazzone M, Carmeliet P. Antiangiogenic therapy, hypoxia, and metastasis: risky liaisons, or not? Nat Rev Clin Oncol 2011;8:393.
Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Investig 2009;119:1420–8.
Article CAS PubMed PubMed Central Google Scholar
Zeisberg M, Neilson EG. Biomarkers for epithelial-mesenchymal transitions. J Clin Investig 2009;119:1429–37.
Article CAS PubMed PubMed Central Google Scholar
Wang GL, Semenza GL. General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proc Natl Acad Sci USA. 1993;90:4304–8.
Article CAS PubMed PubMed Central Google Scholar
Ravenna L, Salvatori L, Russo MA. HIF3α: the little we know. FEBS J. 2016;283:993–1003.
Article CAS PubMed Google Scholar
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases. Cancer Res. 1999;59:5830–5.
Imamura T, Kikuchi H, Herraiz M, Park D, Mizukami Y, Mino-Kenduson M, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer. 2009;124:763–71.
Article CAS PubMed PubMed Central Google Scholar
Nagaraju GP, Bramhachari PV, Raghu G, El-Rayes BF. Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis. Cancer Lett. 2015;366:11–18.
Article CAS PubMed Google Scholar
Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE. 2013;8:e80337.
Article PubMed PubMed Central Google Scholar
Li H, Rokavec M, Jiang L, Horst D, Hermeking H. Antagonistic effects of p53 and HIF1A on microRNA-34a regulation of PPP1R11 and STAT3 and hypoxia-induced epithelial to mesenchymal transition in colorectal cancer cells. Gastroenterology. 2017;153:505–20.
Article CAS PubMed Google Scholar
Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson JK, et al. Hypoxia-inducible factor-2alpha activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 2012;72:2285–93.
Article CAS PubMed PubMed Central Google Scholar
Xue X, Ramakrishnan SK, Shah YM. Activation of HIF-1α does not increase intestinal tumorigenesis. Am J Physiol Gastrointest Liver Physiol 2014;307:G187–95.
Article CAS PubMed PubMed Central Google Scholar
Xue X, Jungles K, Onder G, Samhoun J, Győrffy B, Hardiman K. HIF-3α1 promotes colorectal tumor cell growth by activation of JAK-STAT3 signaling. Oncotarget. 2016;7:11567–79.
Article PubMed PubMed Central Google Scholar
Morales M, Xue X. Targeting iron metabolism in cancer therapy. Theranostics. 2021;11:8412–29.
Article CAS PubMed PubMed Central Google Scholar
Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, et al. Transferrin receptor-mediated iron uptake promotes colon tumorigenesis. Adv Sci. 2023;10:2207693.
Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, et al. Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells. Nat Metab 2021;3:969–82.
Article CAS PubMed PubMed Central Google Scholar
Mehta KJ, Sharp PA. Iron elevates mesenchymal and metastatic biomarkers in HepG2 cells. Sci Rep. 2020;10:21926.
Article CAS PubMed PubMed Central Google Scholar
Xue X, Ramakrishnan S, Weisz K, Triner D, Xie L, Győrffy B, et al. Iron uptake via DMT1 integrates cell cycle with JAK-STAT3 signaling to promote colorectal tumorigenesis. Cell Metab. 2016;24:447–61.
Article CAS PubMed PubMed Central Google Scholar
Triner D, Xue X, Schwartz AJ, Jung I, Colacino JA, Shah YM. Epithelial hypoxia-inducible factor 2α facilitates the progression of colon tumors through recruiting neutrophils. Mol Cell Biol. 2017;37:e00481–16.
Article PubMed PubMed Central Google Scholar
Yin K, Lee J, Liu Z, Kim H, Martin DR, Wu D, et al. Mitophagy protein PINK1 suppresses colon tumor growth by metabolic reprogramming via p53 activation and reducing acetyl-CoA production. Cell Death Differ. 2021;28:2421–35.
Article CAS PubMed PubMed Central Google Scholar
Beltran M, Puig I, Peña C, García JM, Alvarez AB, Peña R, et al. A natural antisense transcript regulates Zeb2/Sip1 gene expression during Snail1-induced epithelial-mesenchymal transition. Genes Dev 2008;22:756–69.
Article CAS PubMed PubMed Central Google Scholar
Xue X, Ramakrishnan S, Anderson E, Taylor M, Zimmermann EM, Spence JR, et al. Endothelial PAS domain protein 1 activates the inflammatory response in the intestinal epithelium to promote colitis in mice. Gastroenterology. 2013;145:831–41.
Article CAS PubMed Google Scholar
Jędroszka D, Orzechowska M, Hamouz R, Górniak K, Bednarek AK. Markers of epithelial-to-mesenchymal transition reflect tumor biology according to patient age and Gleason score in prostate cancer. PLoS ONE. 2017;12:e0188842.
Article PubMed PubMed Central Google Scholar
Higgins DF, Kimura K, Bernhardt WM, Shrimanker N, Akai Y, Hohenstein B, et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to mesenchymal transition. J Clin Investig 2007;117:3810–20.
CAS PubMed PubMed Central Google Scholar
Zhang W, Shi X, Peng Y, Wu M, Zhang P, Xie R, et al. HIF-1α promotes epithelial-mesenchymal transition and metastasis through direct regulation of ZEB1 in colorectal cancer. PLoS ONE. 2015;10:e0129603.
Article PubMed PubMed Central Google Scholar
Bartha Á, Győrffy B. TNMplot.com: a web tool for the comparison of gene expression in normal, tumor and metastatic tissues. Int J Mol Sci. 2021;22:2622.
Article CAS PubMed PubMed Central Google Scholar
Soares KC, Foley K, Olino K, Leubner A, Mayo SC, Jain A, et al. A preclinical murine model of hepatic metastases. J Vis Exp. 2014; https://doi.org/10.3791/51677.
Wang Y, Yu L, Ding J, Chen Y. Iron metabolism in cancer. Int J Mol Sci. 2018;20:95.
Article PubMed PubMed Central Google Scholar
Bhutia YD, Ogura J, Grippo PJ, Torres C, Sato T, Wachtel M, et al. Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer. Asian J Pharm Sci. 2020;15:237–51.
Article PubMed PubMed Central Google Scholar
Bianchi L, Tacchini L, Cairo G. HIF-1-mediated activation of transferrin receptor gene transcription by iron chelation. Nucleic Acids Res. 1999;27:4223–7.
Article CAS PubMed PubMed Central Google Scholar
Fang H-Y, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009;114:844–59.
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