van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, et al. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001;7(6):719–24.

Article  PubMed  PubMed Central  Google Scholar 

Karron RA, San Mateo J, Wanionek K, Collins PL, Buchholz UJ. Evaluation of a Live Attenuated Human Metapneumovirus Vaccine in Adults and Children. J Pediatric Infect Dis Soc. 2018;7(1):86–9.

Article  PubMed  Google Scholar 

Divarathna MVM, Rafeek RAM, Noordeen F. A review on epidemiology and impact of human metapneumovirus infections in children using TIAB search strategy on PubMed and PubMed Central articles. Rev Med Virol. 2020;30(1): e2090.

Article  PubMed  Google Scholar 

Wang X, Li Y, Deloria-Knoll M, Madhi SA, Cohen C, Ali A, et al. Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health. 2021;9(1):e33–43.

Article  CAS  PubMed  Google Scholar 

Belingheri M, Paladino ME, Piacenti S, Riva MA. Effects of COVID-19 lockdown on epidemic diseases of childhood. J Med Virol. 2021;93(1):153–4.

Article  CAS  PubMed  Google Scholar 

Izu A, Nunes MC, Solomon F, Baillie V, Serafin N, Verwey C, et al. All-cause and pathogen-specific lower respiratory tract infection hospital admissions in children younger than 5 years during the COVID-19 pandemic (2020–22) compared with the pre-pandemic period (2015–19) in South Africa: an observational study. Lancet Infect Dis. 2023.

Perez A, Lively JY, Curns A, Weinberg GA, Halasa NB, Staat MA, et al. Respiratory Virus Surveillance Among Children with Acute Respiratory Illnesses - New Vaccine Surveillance Network, United States, 2016–2021. MMWR Morb Mortal Wkly Rep. 2022;71(40):1253–9.

Article  PubMed  PubMed Central  Google Scholar 

Hatter L, Eathorne A, Hills T, Bruce P, Beasley R. Respiratory syncytial virus: paying the immunity debt with interest. Lancet Child Adolesc Health. 2021;5(12):e44–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen R, Ashman M, Taha MK, Varon E, Angoulvant F, Levy C, et al. Pediatric Infectious Disease Group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap? Infect Dis Now. 2021;51(5):418–23.

Article  PubMed  PubMed Central  Google Scholar 

Foley DA, Yeoh DK, Minney-Smith CA, Shin C, Hazelton B, Hoeppner T, et al. A surge in human metapneumovirus paediatric respiratory admissions in Western Australia following the reduction of SARS-CoV-2 non-pharmaceutical interventions. J Paediatr Child Health. 2023;59(8):987–91.

Article  PubMed  Google Scholar 

Foley DA, Sikazwe CT, Minney-Smith CA, Ernst T, Moore HC, Nicol MP, et al. An Unusual Resurgence of Human Metapneumovirus in Western Australia Following the Reduction of Non-Pharmaceutical Interventions to Prevent SARS-CoV-2 Transmission. Viruses. 2022;14(10).

Zhao H, Feng Q, Feng Z, Zhu Y, Ai J, Xu B, et al. Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study. Virol Sin. 2022;37(6):874–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Wei T, Ma F, Wang H, Guo J, Chen A, et al. Epidemiology and genotypic diversity of human metapneumovirus in paediatric patients with acute respiratory infection in Beijing, China. Virol J. 2021;18(1):40.

Article  PubMed  PubMed Central  Google Scholar 

Cong S, Wang C, Wei T, Xie Z, Huang Y, Tan J, et al. Human metapneumovirus in hospitalized children with acute respiratory tract infections in Beijing. China Infect Genet Evol. 2022;106: 105386.

Article  CAS  PubMed  Google Scholar 

Zeng SZ, Xiao NG, Zhong LL, Yu T, Zhang B, Duan ZJ. Clinical features of human metapneumovirus genotypes in children with acute lower respiratory tract infection in Changsha. China J Med Virol. 2015;87(11):1839–45.

Article  PubMed  Google Scholar 

Zhang C, Du LN, Zhang ZY, Qin X, Yang X, Liu P, et al. Detection and genetic diversity of human metapneumovirus in hospitalized children with acute respiratory infections in Southwest China. J Clin Microbiol. 2012;50(8):2714–9.

Article  PubMed  PubMed Central  Google Scholar 

Jongbloed M, Leijte WT, Linssen CFM, van den Hoogen BG, van Gorp ECM, de Kruif MD. Clinical impact of human metapneumovirus infections before and during the COVID-19 pandemic. Infect Dis (Lond). 2021;53(7):488–97.

Article  CAS  PubMed  Google Scholar 

Li SY, Tong J, Liu Y, Shen W, Hu P. Targeted next generation sequencing is comparable with metagenomic next generation sequencing in adults with pneumonia for pathogenic microorganism detection. J Infection. 2022;85(5):E127–9.

Article  CAS  Google Scholar 

Subspecialty Group of Respiratory Diseases TSoP, Chinese Medical Association The Editorial Board CJoP. [Guidelines for management of community acquired pneumonia in children(the revised edition of 2013) (II)]. Zhonghua Er Ke Za Zhi. 2013;51(11):856-62.

Subspecialty Group of Respiratory Diseases TSoPCMA, Editorial Board CJoP. [Guidelines for management of community acquired pneumonia in children (the revised edition of 2013) (I)]. Zhonghua Er Ke Za Zhi. 2013;51(10):745-52.

Wang X, Li Y, O’Brien KL, Madhi SA, Widdowson MA, Byass P, et al. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study. Lancet Glob Health. 2020;8(4):e497–510.

Article  PubMed  PubMed Central  Google Scholar 

Simon AK, Hollander GA, McMichael A. Evolution of the immune system in humans from infancy to old age. Proc Biol Sci. 1821;2015(282):20143085.

Google Scholar 

Schildgen V, van den Hoogen B, Fouchier R, Tripp RA, Alvarez R, Manoha C, et al. Human Metapneumovirus: lessons learned over the first decade. Clin Microbiol Rev. 2011;24(4):734–54.

Article  PubMed  PubMed Central  Google Scholar 

Coverstone AM, Wang L, Sumino K. Beyond Respiratory Syncytial Virus and Rhinovirus in the Pathogenesis and Exacerbation of Asthma: The Role of Metapneumovirus, Bocavirus and Influenza Virus. Immunol Allergy Clin North Am. 2019;39(3):391–401.

Article  PubMed  PubMed Central  Google Scholar 

Wilkesmann A, Schildgen O, Eis-Hubinger AM, Geikowski T, Glatzel T, Lentze MJ, et al. Human metapneumovirus infections cause similar symptoms and clinical severity as respiratory syncytial virus infections. Eur J Pediatr. 2006;165(7):467–75.

Article  PubMed  Google Scholar 

Cui A, Xie Z, Xu J, Hu K, Zhu R, Li Z, et al. Comparative analysis of the clinical and epidemiological characteristics of human influenza virus versus human respiratory syncytial virus versus human metapneumovirus infection in nine provinces of China during 2009–2021. J Med Virol. 2022;94(12):5894–903.

Article  CAS  PubMed  Google Scholar 

Howard LM, Edwards KM, Zhu Y, Grijalva CG, Self WH, Jain S, et al. Clinical Features of Human Metapneumovirus-Associated Community-acquired Pneumonia Hospitalizations. Clin Infect Dis. 2021;72(1):108–17.

PubMed  Google Scholar 

Zhu Y, Xu B, Li C, Chen Z, Cao L, Fu Z, et al. A Multicenter Study of Viral Aetiology of Community-Acquired Pneumonia in Hospitalized Children in Chinese Mainland. Virol Sin. 2021;36(6):1543–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nickbakhsh S, Mair C, Matthews L, Reeve R, Johnson PCD, Thorburn F, et al. Virus-virus interactions impact the population dynamics of influenza and the common cold. Proc Natl Acad Sci U S A. 2019;116(52):27142–50.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Damania B, Kenney SC, Raab-Traub N. Epstein-Barr virus: Biology and clinical disease. Cell. 2022;185(20):3652–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vandini S, Biagi C, Fischer M, Lanari M. Impact of Rhinovirus Infections in Children. Viruses. 2019;11(6).

Du Y, Li W, Guo Y, Li L, Chen Q, He L, et al. Epidemiology and genetic characterization of human metapneumovirus in pediatric patients from Hangzhou China. J Med Virol. 2022;94(11):5401–8.

Article  CAS  PubMed  Google Scholar 

Moriyama M, Hugentobler WJ, Iwasaki A. Seasonality of Respiratory Viral Infections. Annu Rev Virol. 2020;7(1):83–101.

Article  CAS  PubMed  Google Scholar 

Esposito S, Daleno C, Prunotto G, Scala A, Tagliabue C, Borzani I, et al. Impact of viral infections in children with community-acquired pneumonia: results of a study of 17 respiratory viruses. Influenza Other Respir Viruses. 2013;7(1):18–26.

Article  PubMed  Google Scholar 

Guerrero-Plata A, Casola A, Garofalo RP. Human metapneumovirus induces a profile of lung cytokines distinct from that of respiratory syncytial virus. J Virol. 2005;79(23):14992–7.

Article  CAS  PubMed  PubMed Central  Google Scholar