Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71:209–49.
Villanueva A. Hepatocellular Carcinoma. N Engl J Med. 2019;380:1450–62.
Article CAS PubMed Google Scholar
Galle PR, Tovoli F, Foerster F, Worns MA, Cucchetti A, Bolondi L. The treatment of intermediate stage tumours beyond TACE: from surgery to systemic therapy. J Hepatol. 2017;67:173–83.
Sangro B, Sarobe P, Hervas-Stubbs S, Melero I. Advances in immunotherapy for hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2021;18:525–43.
Article PubMed PubMed Central Google Scholar
Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, et al. Landscape of infiltrating T cells in Liver Cancer revealed by single-cell sequencing. Cell. 2017;169:1342–56. e16.
Article CAS PubMed Google Scholar
Zhang Q, He Y, Luo N, Patel SJ, Han Y, Gao R, Modak M et al. Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma. Cell. 2019;179:829 – 45.e20.
Llovet JM, Castet F, Heikenwalder M, Maini MK, Mazzaferro V, Pinato DJ, Pikarsky E, et al. Immunotherapies for hepatocellular carcinoma. Nat Reviews Clin Oncol. 2021;19:151–72.
Cheng K, Cai N, Zhu J, Yang X, Liang H, Zhang W. Tumor-associated macrophages in liver cancer: from mechanisms to therapy. Cancer Commun (Lond). 2022;42:1112–40.
Yu J, Green MD, Li S, Sun Y, Journey SN, Choi JE, Rizvi SM, et al. Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination. Nat Med. 2021;27:152–64.
Article CAS PubMed PubMed Central Google Scholar
Ho DW, Tsui YM, Chan LK, Sze KM, Zhang X, Cheu JW, Chiu YT, et al. Single-cell RNA sequencing shows the immunosuppressive landscape and tumor heterogeneity of HBV-associated hepatocellular carcinoma. Nat Commun. 2021;12:3684.
Article CAS PubMed PubMed Central Google Scholar
Chen S, Saeed AFUH, Liu Q, Jiang Q, Xu H, Xiao GG, Rao L, et al. Macrophages in immunoregulation and therapeutics. Signal Transduct Target Therapy. 2023;8:207.
Mantovani A, Allavena P, Marchesi F, Garlanda C. Macrophages as tools and targets in cancer therapy. Nat Rev Drug Discov. 2022;21:799–820.
Article CAS PubMed PubMed Central Google Scholar
Li X, Yao W, Yuan Y, Chen P, Li B, Li J, Chu R, et al. Targeting of tumour-infiltrating macrophages via CCL2/CCR2 signalling as a therapeutic strategy against hepatocellular carcinoma. Gut. 2017;66:157–67.
Article CAS PubMed Google Scholar
Gordon SR, Maute RL, Dulken BW, Hutter G, George BM, McCracken MN, Gupta R, et al. PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity. Nature. 2017;545:495–9.
Article CAS PubMed PubMed Central Google Scholar
Lu LG, Zhou ZL, Wang XY, Liu BY, Lu JY, Liu S, Zhang GB et al. PD-L1 blockade liberates intrinsic antitumourigenic properties of glycolytic macrophages in hepatocellular carcinoma. Gut. 2022.
Barkal AA, Brewer RE, Markovic M, Kowarsky M, Barkal SA, Zaro BW, Krishnan V, et al. CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. Nature. 2019;572:392–6.
Article CAS PubMed PubMed Central Google Scholar
Wei R, Zhu W-W, Yu G-Y, Wang X, Gao C, Zhou X, Lin Z-F, et al. S100 calcium-binding protein A9 from tumor-associated macrophage enhances cancer stem cell-like properties of hepatocellular carcinoma. Int J Cancer. 2021;148:1233–44.
Sprinzl MF, Puschnik A, Schlitter AM, Schad A, Ackermann K, Esposito I, Lang H, et al. Sorafenib inhibits macrophage-induced growth of hepatoma cells by interference with insulin-like growth factor-1 secretion. J Hepatol. 2015;62:863–70.
Article CAS PubMed Google Scholar
Chen J, Lin Z, Liu L, Zhang R, Geng Y, Fan M, Zhu W, et al. GOLM1 exacerbates CD8 + T cell suppression in hepatocellular carcinoma by promoting exosomal PD-L1 transport into tumor-associated macrophages. Signal Transduct Target Therapy. 2021;6:397.
Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, et al. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. 2019;68:1653–66.
Article CAS PubMed Google Scholar
Hao X, Zheng Z, Liu H, Zhang Y, Kang J, Kong X, Rong D, et al. Inhibition of APOC1 promotes the transformation of M2 into M1 macrophages via the ferroptosis pathway and enhances anti-PD1 immunotherapy in hepatocellular carcinoma based on single-cell RNA sequencing. Redox Biol. 2022;56:102463.
Article CAS PubMed PubMed Central Google Scholar
Zhou S-L, Yin D, Hu Z-Q, Luo C-B, Zhou Z-J, Xin H-Y, Yang X-R et al. A positive Feedback Loop between Cancer Stem-Like cells and Tumor-Associated neutrophils Controls Hepatocellular Carcinoma Progression. Hepatology (Baltimore, Md.). 2019;70:1214–30.
Yu SJ, Ma C, Heinrich B, Brown ZJ, Sandhu M, Zhang Q, Fu Q, et al. Targeting the crosstalk between cytokine-induced killer cells and myeloid-derived suppressor cells in hepatocellular carcinoma. J Hepatol. 2019;70:449–57.
Article CAS PubMed Google Scholar
Geh D, Leslie J, Rumney R, Reeves HL, Bird TG, Mann DA. Neutrophils as potential therapeutic targets in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 2022;19:257–73.
Article CAS PubMed Google Scholar
Wong L, Bozhilov K, Hernandez B, Kwee S, Chan O, Ellis L, LeMarchand L. Underlying liver disease and advanced stage liver cancer are associated with elevated neutrophil-lymphocyte ratio. Clin Mol Hepatol. 2019;25:305–16.
Article PubMed PubMed Central Google Scholar
Veras FP, Pontelli MC, Silva CM, Toller-Kawahisa JE, de Lima M, Nascimento DC, Schneider AH et al. SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology. J Exp Med. 2020;217.
Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol. 2012;189:2689–95.
Article CAS PubMed Google Scholar
Yang L, Liu Q, Zhang X, Liu X, Zhou B, Chen J, Huang D, et al. DNA of neutrophil extracellular traps promotes cancer metastasis via CCDC25. Nature. 2020;583:133–8.
Article CAS PubMed Google Scholar
Xiao Y, Cong M, Li J, He D, Wu Q, Tian P, Wang Y et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell. 2021;39.
van der Windt DJ, Sud V, Zhang H, Varley PR, Goswami J, Yazdani HO, Tohme S, et al. Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis. Hepatology (Baltimore MD). 2018;68:1347–60.
Article CAS PubMed Google Scholar
Yang L-Y, Luo Q, Lu L, Zhu W-W, Sun H-T, Wei R, Lin Z-F, et al. Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response. J Hematol Oncol. 2020;13:3.
Article CAS PubMed PubMed Central Google Scholar
Xue R, Zhang Q, Cao Q, Kong R, Xiang X, Liu H, Feng M, et al. Liver tumour immune microenvironment subtypes and neutrophil heterogeneity. Nature. 2022;612:141–7.
Article CAS PubMed Google Scholar
Wang L, Liu Y, Dai Y, Tang X, Yin T, Wang C, Wang T, et al. Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment. Gut. 2023;72:958–71.
Article CAS PubMed Google Scholar
Meng Y, Ye F, Nie P, Zhao Q, An L, Wang W, Qu S et al. Immunosuppressive CD10 + ALPL + neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells. J Hepatol. 2023.
Gungabeesoon J, Gort-Freitas NA, Kiss M, Bolli E, Messemaker M, Siwicki M, Hicham M et al. A neutrophil response linked to tumor control in immunotherapy. Cell. 2023;186.
Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca JM et al. T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants. Cell. 2023;186.
Del Prete A, Salvi V, Soriani A, Laffranchi M, Sozio F, Bosisio D, Sozzani S. Dendritic cell subsets in cancer immunity and tumor antigen sensing. Cell Mol Immunol. 2023;20:432–47.
Article PubMed PubMed Central Google Scholar
Zhou Z-J, Xin H-Y, Li J, Hu Z-Q, Luo C-B, Zhou S-L. Intratumoral plasmacytoid dendritic cells as a poor prognostic factor for hepatocellular carcinoma following curative resection. Cancer Immunol Immunotherapy: CII. 2019;68:1223–33.
Article PubMed Central Google Scholar
Pang L, Ng KT-P, Liu J, Yeung W-HO, Zhu J, Chiu T-LS, Liu H, et al. Plasmacytoid dendritic cells recruited by HIF-1α/eADO/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma. Cancer Lett. 2021;522:80–92.
Article CAS PubMed Google Scholar
Pedroza-Gonzalez A, Zhou G, Vargas-Mendez E, Boor PP, Mancham S, Verhoef C, Polak WG, et al. Tumor-infiltrating plasmacytoid dendritic cells promote immunosuppression by Tr1 cells in human liver tumors. Oncoimmunology. 2015;4:e1008355.
Article PubMed PubMed Central Google Scholar
Suthen S, Lim CJ, Nguyen PHD, Dutertre CA, Lai HLH, Wasser M, Chua C, et al. Hypoxia-driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC. Hepatology. 2022;76:1329–44.
Article CAS PubMed Google Scholar
Akkaya B, Oya Y, Akkaya M, Al Souz J, Holstein AH, Kamenyeva O, Kabat J, et al. Regulatory T cells mediate specific suppression by depleting peptide-MHC class II from dendritic cells. Nat Immunol. 2019;20:218–31.
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