TROP2 promotes PINK1-mediated mitophagy and apoptosis to accelerate the progression of senile chronic obstructive pulmonary disease by up-regulating DRP1 expression
AbbreviationsTROP2
trophoblast antigen 2
COPD
chronic obstructive pulmonary disease
ATP
adenosine triphosphate
DRP1
dynamin-related protein 1
PINK1
PTEN-induced putative kinase 1
BALF
bronchoalveolar lavage fluid
MMP
mitochondrial membrane potential
ROS
reactive oxygen species
Keywords
Chronic obstructive pulmonary disease
TROP2
DRP1
PINK1
Mitophagy
Data availability
The labeled dataset used to support the findings of this study are available from the corresponding author upon request.
© 2024 The Authors. Published by Elsevier Inc.
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