Petrick JL, Reeve BB, Kucharska-Newton AM, Foraker RE, Platz EA, Stearns SC, et al. Functional status declines among cancer survivors: Trajectory and contributing factors. J Geriatric Oncol. 2014;5:359–67. https://doi.org/10.1016/j.jgo.2014.06.002.

Article  Google Scholar 

Winters-Stone KM, Medysky ME, Savin MA. Patient-reported and objectively measured physical function in older breast cancer survivors and cancer-free controls. J Geriatric Oncol. 2019;10:311–6. https://doi.org/10.1016/j.jgo.2018.10.006.

Article  Google Scholar 

Bennett JA, Winters-Stone KM, Dobek J, Nail LM. Frailty in Older Breast Cancer Survivors: Age, Prevalence, and Associated Factors. Oncol Nurs Forum. 2013;40:E126–34. https://doi.org/10.1188/13.ONF.E126-E134.

Article  PubMed  PubMed Central  Google Scholar 

Karlsen RV, Frederiksen K, Larsen MB, von Heymann-Horan AB, Appel CW, Christensen J, et al. The impact of a breast cancer diagnosis on health-related quality of life. A prospective comparison among middle-aged to elderly women with and without breast cancer. Acta Oncologica. 2016;55:720–7. https://doi.org/10.3109/0284186X.2015.1127415.

Article  PubMed  Google Scholar 

Weaver KE, Leach CR, Leng X, Danhauer SC, Klepin HD, Vaughan L, et al. Physical Functioning among Women 80 Years of Age and Older With and Without a Cancer History. GERONA. 2016;71:S23-30. https://doi.org/10.1093/gerona/glv073.

Article  Google Scholar 

Sedrak MS, Kirkland JL, Tchkonia T, Kuchel GA. Accelerated aging in older cancer survivors. J Am Geriatr Soc. 2021;69:3077–80. https://doi.org/10.1111/jgs.17461.

Article  PubMed  PubMed Central  Google Scholar 

Amitani M, Oba T, Kiyosawa N, Morikawa H, Chino T, Soma A, et al. Skeletal muscle loss during neoadjuvant chemotherapy predicts poor prognosis in patients with breast cancer. BMC Cancer. 2022;22:327. https://doi.org/10.1186/s12885-022-09443-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guigni BA, Callahan DM, Tourville TW, Miller MS, Fiske B, Voigt T, et al. Skeletal muscle atrophy and dysfunction in breast cancer patients: role for chemotherapy-derived oxidant stress. Am J Physiol Cell Physiol. 2018;315:C744–56. https://doi.org/10.1152/ajpcell.00002.2018.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mandelblatt JS, Zhou X, Small BJ, Ahn J, Zhai W, Ahles T, et al. Deficit Accumulation Frailty Trajectories of Older Breast Cancer Survivors and Non-Cancer Controls: The Thinking and Living With Cancer Study. JNCI: J National Cancer Inst. 2021;113:1053–64. https://doi.org/10.1093/jnci/djab003.

Article  Google Scholar 

Ganz PA, Kwan L, Stanton AL, Bower JE, Belin TR. Physical and Psychosocial Recovery in the Year After Primary Treatment of Breast Cancer. JCO. 2011;29:1101–9. https://doi.org/10.1200/JCO.2010.28.8043.

Article  Google Scholar 

Deimling GT, Arendt JA, Kypriotakis G, Bowman KF. Functioning of Older, Long-Term Cancer Survivors: The Role of Cancer and Comorbidities: CANCER AND COMORBIDITIES. J Am Geriatr Soc. 2009;57:S289–92. https://doi.org/10.1111/j.1532-5415.2009.02515.x.

Article  PubMed  Google Scholar 

Fried TR, Bradley EH, Towle VR, Allore H. Understanding the treatment preferences of seriously ill patients. N Engl J Med. 2002;346:1061–6. https://doi.org/10.1056/NEJMsa012528.

Article  PubMed  Google Scholar 

Seghers PALN, Wiersma A, Festen S, Stegmann ME, Soubeyran P, Rostoft S, et al. Patient Preferences for Treatment Outcomes in Oncology with a Focus on the Older Patient-A Systematic Review. Cancers (Basel). 2022;14:1147. https://doi.org/10.3390/cancers14051147.

Article  PubMed  Google Scholar 

Fried TR, Tinetti ME, Iannone L, O’Leary JR, Towle V, Van Ness PH. Health outcome prioritization as a tool for decision making among older persons with multiple chronic conditions. Arch Intern Med. 2011;171:1854–6. https://doi.org/10.1001/archinternmed.2011.424.

Article  PubMed  PubMed Central  Google Scholar 

DuMontier C, Loh KP, Soto-Perez-de-Celis E, Dale W. Decision Making in Older Adults With Cancer. J Clin Oncol. 2021;39:2164–74. https://doi.org/10.1200/JCO.21.00165.

Article  PubMed  PubMed Central  Google Scholar 

Nightingale G, Battisti NML, Loh KP, Puts M, Kenis C, Goldberg A, et al. Perspectives on functional status in older adults with cancer: An interprofessional report from the International Society of Geriatric Oncology (SIOG) nursing and allied health interest group and young SIOG. J Geriatr Oncol. 2021;12:658–65. https://doi.org/10.1016/j.jgo.2020.10.018.

Article  CAS  PubMed  Google Scholar 

Office of Cancer Survivorship. Statistics, Graphs and Definitions. Statistics, Graphs and Definitions n.d. https://cancercontrol.cancer.gov/ocs/statistics (accessed August 23, 2021).

Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, et al. Cancer treatment and survivorship statistics, 2019. CA CANCER J CLIN. 2019;69:24.

Article  Google Scholar 

Guida JL, Ahles TA, Belsky D, Campisi J, Cohen HJ, DeGregori J, et al. Measuring Aging and Identifying Aging Phenotypes in Cancer Survivors. J Natl Cancer Inst. 2019;111:1245–54. https://doi.org/10.1093/jnci/djz136.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guida JL, Agurs-Collins T, Ahles TA, Campisi J, Dale W, Demark-Wahnefried W, et al. Strategies to Prevent or Remediate Cancer and Treatment-Related Aging. JNCI: J Nat Cancer Inst. 2021;113:112–22. https://doi.org/10.1093/jnci/djaa060.

Article  CAS  PubMed  Google Scholar 

Gresham G, Dy SM, Zipunnikov V, Browner IS, Studenski SA, Simonsick EM, et al. Fatigability and endurance performance in cancer survivors: Analyses from the Baltimore Longitudinal Study of Aging: Fatigability in Cancer Survivors. Cancer. 2018;124:1279–87. https://doi.org/10.1002/cncr.31238.

Article  PubMed  Google Scholar 

Cespedes Feliciano EM, Vasan S, Luo J, Binder AM, Chlebowski RT, Quesenberry C, et al. Long-term Trajectories of Physical Function Decline in Women With and Without Cancer. JAMA Oncol. 2023;9:395–403. https://doi.org/10.1001/jamaoncol.2022.6881.

Article  PubMed  PubMed Central  Google Scholar 

Siddique A, Simonsick EM, Gallicchio L. Functional decline among older cancer survivors in the Baltimore longitudinal study of aging. J Am Geriatr Soc. 2021:jgs.17369. https://doi.org/10.1111/jgs.17369.

Michael YL, Wu C, Pan K, Seguin-Fowler RA, Garcia DO, Zaslavsky O, et al. Postmenopausal Breast Cancer and Physical Function Change: A Difference-in-Differences Analysis. J Am Geriatr Soc. 2020;68:1029–36. https://doi.org/10.1111/jgs.16323.

Article  PubMed  Google Scholar 

Hurria A, Soto-Perez-de-Celis E, Allred JB, Cohen HJ, Arsenyan A, Ballman K, et al. Functional Decline and Resilience in Older Women Receiving Adjuvant Chemotherapy for Breast Cancer. J Am Geriatr Soc. 2019;67:920–7. https://doi.org/10.1111/jgs.15493.

Article  PubMed  Google Scholar 

Alfano CM, Peng J, Andridge RR, Lindgren ME, Povoski SP, Lipari AM, et al. Inflammatory Cytokines and Comorbidity Development in Breast Cancer Survivors Versus Noncancer Controls: Evidence for Accelerated Aging? JCO. 2017;35:149–56. https://doi.org/10.1200/JCO.2016.67.1883.

Article  Google Scholar 

Magnuson A, Sedrak MS, Gross CP, Tew WP, Klepin HD, Wildes TM, et al. Development and Validation of a Risk Tool for Predicting Severe Toxicity in Older Adults Receiving Chemotherapy for Early-Stage Breast Cancer. JCO. 2021;39:608–18. https://doi.org/10.1200/JCO.20.02063.

Article  CAS  Google Scholar 

Ji J, Sun C-L, Cohen HJ, Muss HB, Bae M, Sedrak MS. Toxicity risk score and clinical decline after adjuvant chemotherapy in older breast cancer survivors. J Natl Cancer Inst. 2023;115:578–85. https://doi.org/10.1093/jnci/djad029.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji J, Sun C-L, Cohen HJ, Synold T, Muss H, Sedrak MS. Inflammation and Clinical Decline After Adjuvant Chemotherapy in Older Adults With Breast Cancer: Results From the Hurria Older Patients Prospective Study. J Clin Oncol. 2023;41:307–15. https://doi.org/10.1200/JCO.22.01217.

Article  CAS  PubMed  Google Scholar 

Sedrak MS, Sun C-L, Ji J, Cohen HJ, Gross CP, Tew WP, et al. Low-Intensity Adjuvant Chemotherapy for Breast Cancer in Older Women: Results From the Prospective Multicenter HOPE Trial. J Clin Oncol. 2023;41:316–26. https://doi.org/10.1200/JCO.22.01440.

Article  CAS  PubMed  Google Scholar 

Okabe T, Suzuki M, Goto H, Iso N, Cho K, Hirata K, et al. Sex Differences in Age-Related Physical Changes among Community-Dwelling Adults. J Clin Med. 2021;10:4800. https://doi.org/10.3390/jcm10204800.

Article  PubMed  PubMed Central  Google Scholar 

Lin M-H, Chen L-J, Huang S-T, Meng L-C, Lee W-J, Peng L-N, et al. Age and sex differences in associations between self-reported health, physical function, mental function and mortality. Arch Gerontol Geriatr. 2022;98: 104537. https://doi.org/10.1016/j.archger.2021.104537.

Article  PubMed  Google Scholar 

Hurria A, Gupta S, Zauderer M, Zuckerman EL, Cohen HJ, Muss H, et al. Developing a cancer-specific geriatric assessment: A feasibility study. Cancer. 2005;104:1998–2005. https://doi.org/10.1002/cncr.21422.

Article  PubMed  Google Scholar 

Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP, et al. Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol. 2011;29:3457–65. https://doi.org/10.1200/JCO.2011.34.7625.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A, et al. Validation of a Prediction Tool for Chemotherapy Toxicity in Older Adults With Cancer. J Clin Oncol. 2016;34:2366–71. https://doi.org/10.1200/JCO.2015.65.4327.

Article  PubMed  PubMed Central  Google Scholar 

Yates JW, Chalmer B, McKegney FP. Evaluation of patients with advanced cancer using the Karnofsky performance status. Cancer. 1980;45:2220–4. https://doi.org/10.1002/1097-0142(19800415)45:8%3c2220::aid-cncr2820450835%3e3.0.co;2-q.

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