Vaduganathan M, Mensah GA, Turco JV, Fuster V, Roth GA. The global burden of cardiovascular diseases and risk: a compass for future health. J Am Coll Cardiol. 2022;80:2361–71.

Article  PubMed  Google Scholar 

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. on behalf of the American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S158–90.

Article  CAS  PubMed  Google Scholar 

Sun H, Saeedi P, Karuranga S, Pinkepank M, Ogurtsova K, Duncan BB, et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Res Clin Pract. 2022;183: 109119.

Article  PubMed  Google Scholar 

Heald AH, Stedman M, Davies M, Livingston M, Alshames R, Lunt M, et al. Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data. Cardiovasc Endocrinol Metab. 2020;9:183–5.

Article  PubMed  PubMed Central  Google Scholar 

Succurro E, Fiorentino TV, Miceli S, Perticone M, Sciacqua A, Andreozzi F, Sesti G. Relative risk of cardiovascular disease is higher in women with type 2 diabetes, but not in those with prediabetes, as compared with men. Diabetes Care. 2020;43:3070–8.

Article  PubMed  Google Scholar 

Juutilainen A, Kortelainen S, Lehto S, Rönnemaa T, Pyörälä K, Laakso M. Gender difference in the impact of type 2 diabetes on coronary heart disease risk. Diabetes Care. 2004;27:2898–904.

Article  PubMed  Google Scholar 

Shah AD, Langenber Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1–9 million people. Lancet Diabetes Endocrinol. 2015;3:105–13.

Article  PubMed  PubMed Central  Google Scholar 

Bragg F, Holmes MV, Iona A, Guo Y, Du H, Chen Y, China Kadoorie Biobank Collaborative Group, et al. Association between diabetes and cause-specific mortality in rural and urban areas of China. JAMA. 2017;317:280–9.

Article  PubMed  PubMed Central  Google Scholar 

Peters SA, Huxley RR, Woodward M. Diabetes as risk factor for incident coronary heart disease in women compared with men: a systematic review and meta-analysis of 64 cohorts including 858,507 individuals and 28,203 coronary events. Diabetologia. 2014;57:1542–51.

Article  PubMed  Google Scholar 

Prospective Studies Collaboration and Asia Pacific Cohort Studies Collaboration. Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980793 adults from 68 prospective studies. Lancet Diabetes Endocrinol. 2018;6:538–46.

Article  Google Scholar 

Kautzky-Willer A, Leutner M, Harreiter J. Sex differences in type 2 diabetes. Diabetologia. 2023;66:986–1002.

Article  PubMed  PubMed Central  Google Scholar 

Succurro E, Miceli S, Fiorentino TV, Sciacqua A, Perticone M, Andreozzi F, Sesti G. Sex-specific differences in left ventricular mass and myocardial energetic efficiency in non-diabetic, pre-diabetic and newly diagnosed type 2 diabetic subjects. Cardiovasc Diabetol. 2021;20:60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tramunt B, Smati S, Grandgeorge N, Lenfant F, Arnal JF, Montagner A, et al. Sex differences in metabolic regulation and diabetes susceptibility. Diabetologia. 2020;63:453–61.

Article  PubMed  Google Scholar 

Succurro E, Marini MA, Riccio A, Fiorentino TV, Perticone M, Sciacqua A, et al. Sex-differences in insulin sensitivity and insulin secretion in subjects with impaired fasting glucose and impaired glucose tolerance. Diabetes Res Clin Pract. 2022;194: 110185.

Article  CAS  PubMed  Google Scholar 

Yoshida Y, Chen Z, Baudier RL, Krousel-Wood M, Anderson AH, Fonseca VA, et al. Sex differences in the progression of metabolic risk factors in diabetes development. JAMA Netw Open. 2022;5: e2222070.

Article  PubMed  PubMed Central  Google Scholar 

Wright AK, Kontopantelis E, Emsley R, Buchan I, Mamas MA, Sattar N, Ashcroft DM, et al. Cardiovascular risk and risk factor management in type 2 diabetes mellitus. Circulation. 2019;139:2742–53.

Article  PubMed  Google Scholar 

Iozzo P, Chareonthaitawee P, Dutka D, Betteridge DJ, Ferrannini E, Camici PG. Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance. Diabetes. 2002;51:3020–4.

Article  CAS  PubMed  Google Scholar 

Succurro E, Pedace E, Andreozzi F, Papa A, Vizza P, Fiorentino TV, et al. Reduction in global myocardial glucose metabolism in subjects with 1-hour postload hyperglycemia and impaired glucose tolerance. Diabetes Care. 2020;43:669–76.

Article  CAS  PubMed  Google Scholar 

Ohtake T, Yokoyama I, Watanabe T, Momose T, Serezawa T, Nishikawa J, et al. Myocardial glucose metabolism in noninsulin-dependent diabetes mellitus patients evaluated by FDG-PET. J Nucl Med. 1995;36:456–63.

CAS  PubMed  Google Scholar 

Hu L, Qiu C, Wang X, Shao X, Wang Y. The association between diabetes mellitus and reduction in myocardial glucose uptake: a population-based 18F-FDG PET/CT study. BMC Cardiovasc Disord. 2018;18:203.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nielsen R, Jorsal A, Iversen P, Tolbod L, Bouchelouche K, Sørensen J, et al. Heart failure patients with prediabetes and newly diagnosed diabetes display abnormalities in myocardial metabolism. J Nucl Cardiol. 2018;25:169–76.

Article  PubMed  Google Scholar 

Succurro E, Vizza P, Papa A, Cicone F, Monea G, Tradigo G, et al. Metabolic syndrome is associated with impaired insulin-stimulated myocardial glucose metabolic rate in individuals with type 2 diabetes: a cardiac dynamic 18 F-FDG-PET study. Front Cardiovasc Med. 2022;9: 924787.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Devesa A, Fuster V, Vazirani R, García-Lunar I, Oliva B, España S, et al. Cardiac insulin resistance in subjects with metabolic syndrome traits and early subclinical atherosclerosis. Diabetes Care. 2023;46:2050–7.

Article  PubMed  PubMed Central  Google Scholar 

Succurro E, Cicone F, Papa A, Miceli S, Vizza P, Fiorentino TV, et al. Impaired insulin-stimulated myocardial glucose metabolic rate is associated with reduced estimated myocardial energetic efficiency in subjects with different degrees of glucose tolerance. Cardiovasc Diabetol. 2023;22:4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kofoed KF, Carstensen S, Hove JD, Freiberg J, Bangsgaard R, Holm S, et al. Low whole-body insulin sensitivity in patients with ischaemic heart disease is associated with impaired myocardial glucose uptake predictive of poor outcome after revascularisation. Eur J Nucl Med Mol Imaging. 2002;29:991–8.

Article  CAS  PubMed  Google Scholar 

Losi MA, Izzo R, Mancusi C, Wang W, Roman MJ, Lee ET, et al. Depressed myocardial energetic efficiency increases risk of incident heart failure: The Strong Heart Study. J Clin Med. 2019;8:1044.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Simone G, Izzo R, Losi MA, Stabile E, Rozza F, Canciello G, et al. Depressed myocardial energetic efficiency is associated with increased cardiovascular risk in hypertensive left ventricular hypertrophy. J Hypertens. 2016;34:1846–53.

Article  PubMed  Google Scholar 

Tang K, Lin J, Ji X, Lin T, Sun D, Zheng X, et al. Non-alcoholic fatty liver disease with reduced myocardial FDG uptake is associated with coronary atherosclerosis. J Nucl Cardiol. 2021;28:610–20.

Article  PubMed  Google Scholar 

Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med. 2007;356:830–40.

Article  CAS  PubMed  Google Scholar 

El Sayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. On behalf of the American Diabetes Association. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes-2023. Diabetes Care. 2023;46(Suppl 1):S19–40.

Google Scholar 

DeFronzo RA, Tobin JD, Andres R. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol. 1979;237:E214–23.

CAS  PubMed  Google Scholar 

Carson RE. Tracer kinetic modeling in PET. In: Positron emission tomography. London: Springer; 2005. p. 127–59.

Chapter  Google Scholar 

Vizza P, Guzzi PH, Veltri P, Papa A, Cascini GL, Sesti G, Succurro E. Experiences on quantitative cardiac pet analysis. In: 2016 IEEE International Conference on Bioinformatics and Biomedicine (BIBM). Shenzen, China, 2016. p. 1148–53.

Kim G, Jo K, Kim KJ, Lee YH, Han E, Yoon HJ, Wang HJ, Kang ES, Yun M. Visceral adiposity is associated with altered myocardial glucose uptake measured by (18)FDG-PET in 346 subjects with normal glucose tolerance, prediabetes, and type 2 diabetes. Cardiovasc Diabetol. 2015;14:148.

Article  PubMed  PubMed Central  Google Scholar 

Tura A, Pacini G, Moro E, Vrbíková J, Bendlová B, Kautzky-Willer A. Sex- and age-related differences of metabolic parameters in impaired glucose metabolism and type 2 diabetes compared to normal glucose tolerance. Diabetes Res Clin Pract. 2018;146:67–75.

Article  CAS  PubMed  Google Scholar 

Tan Y, Zhang Z, Zheng C, Wintergerst KA, Keller BB, Cai L. Mechanisms of diabetic cardiomyopathy and potential therapeutic strategies: preclinical and clinical evidence. Nat Rev Cardiol. 2020;17:585–607.

Article  PubMed  PubMed Central  Google Scholar 

Sesti G. Pathophysiology of insulin resistance. Best Pract Res Clin Endocrinol Metab. 2006;20:665–79.

Article  CAS  PubMed  Google Sc