Angelica sinensis is a perennial herb widely distributed around the world, serving as a traditional food in a variety of cultures. Angelica sinensis is known for its beneficial health effects, and is commonly used as a dietary supplementary in rehabilitation. Angelica polysaccharide (APS) is a polysaccharide derived from the root of Angelica sinensis by selection, water extraction, concentration and drying, which is linked by multiple identical or different monosaccharides with α- or β-glycosidic bonds [1]. APS extracted from different processing methods or different medicinal parts contains approximately the same type of monosaccharides. But there are significant differences in the content and proportion, which may be the main reason for the differences in pharmacological effects [2]. A large number of studies have shown that APS has pharmacological effects such as hematopoiesis, promoting blood circulation, anti-radiation, lowering blood glucose, and enhancing body immunity in a variety of diseases [3]. In recent years, with the continuous innovation of polysaccharide structure analysis, in vivo tracing, pharmacological efficacy and new preparations, APS related research has also made a number of breakthroughs. This narrative review systematically summarizes the effects of different drying methods and extraction sites on the biological activity of APS and the application of APS in the treatment of diseases, in order to provide a scientific and effective theoretical basis for the subsequent in-depth study.