Available online 25 April 2024, 100886

Author links open overlay panel, , , , , , AbstractIntroduction

Delayed gastric emptying is a prevalent problem in intensive care unit (ICU) patients on mechanical ventilation receiving enteral nutrition. This study aimed to assess the effect of Mentha spicata essential oil (Supermint oral drops) on gastric residual volume (GRV) in this patient population.

Methods

In this clinical trial study, from 01 May 2020 to 30 January 2021, 60 mechanically ventilated ICU patients were randomly assigned to intervention and control groups. From the first day of their feeding, patients in the intervention and control groups respectively received 20 drops of the Supermint and placebo dissolved in 40 ml of water, three times daily for four days. The GRV was measured at the baseline and during four days of intervention. Data were analyzed using a generalized estimation equation (GEE) regression model.

Results

Of the patients, 58.1 % were female. The mean age of patients was 71.5 (SD=14.2), and 65.5% were hospitalized for Coronavirus disease 2019 (COVID-19). The results of the GEE regression model indicated no significant difference between the two groups in terms of the baseline GRV (p=0.181). There was a significant interaction between time and the treatment group (p < 0.001), which suggested that GRV changes over time was different between the two groups. In the control group, the average GRV increased by 0.07 for each unit increase in time, while in the Supermint group, it decreased significantly by 1.09.

Conclusions

The current study's finding suggested that Mentha spicata essential oil may have the potential to reduce GRV in ICU patients undergoing mechanical ventilation. Further studies are needed to confirm this finding.

Section snippetsBackground

One of the problems faced by most frequent patients admitted to the intensive care unit (ICU) is the inability to maintain their own nutritional needs because of being unable to do oral feeding due to an acute condition and a lack of consciousness. Therefore, nutritional support is one of the main components of care in this ward and serves as a crucial factor in promoting the recovery of patients (Shabanpur et al., 2018, Hasanloei et al., 2021). Administration of feed and fluid for people who

Study Design

This study was a randomized, triple-blinded, parallel-group, placebo-controlled trial conducted in mechanically ventilated ICU patients at Bohlol Hospital, Gonabad, Iran, from 01 May 2020 to 30 January 2021.

Participants and setting

The patients admitted to the intensive care unit of Bohlol Hospital were assessed for eligibility. The inclusion criteria were as follows: 1) age of 18 years or over; 2) moderate level of traumatic brain injuries based on the Glasgow Coma Scale (GSC) instrument (the GCS score between 9 and

Results

Of the 65 enrolled patients, five patients were excluded before randomization due to not meeting inclusion criteria or declining to participate. Sixty patients were randomized to the Supermint and placebo groups. In the Supermint group, 29 participants received the intervention, while one was transferred to another ward and did not receive the intervention. In the placebo group, all 30 participants were intended to receive the intervention; however, one participant passed away before the

Discussion

The present study aimed to assess the effect of Mentha spicata essential oil on GRV in patients admitted to the ICU and undergoing mechanical ventilation.

The results of our study demonstrated a significant improvement in gastric emptying over a four-day intervention period in the intervention group who received Mentha spicata essential oil (referred to as the Supermint group) compared to the control group. Previous research on the effects of Mentha spicata essential oil on GRV is limited. In

Conclusion

The current study's finding suggested that Mentha spicata essential oil may have the potential to reduce GRV in ICU patients undergoing mechanical ventilation. Further studies are needed to confirm this finding.

Ethical statement / Clinical trial registration number / Informed consent

The conscious consent of the parent or legal guardian was taken. The study was approved by the Ethics Committee of Gonabad University of Medical Sciences (Ethical code No: IR.GMU.REC.1398.187, Date: 02/25/2020) and registered at the Iranian Registry of Clinical Trials (IRCT code NO: IRCT20191223045868N1. Date: 03/28/2020).

Uncited references

(Bear et al., 2017, Sharifi et al., 2011)

Funding

This study was conducted with support from the Clinical Research Development Unit, Allameh Bohlool Gonabadi hospital, Gonabad University of Medical Sciences, Gonabad, Iran (No.1398-318).

CRediT authorship contribution statement

Javad Asari–Sani-Mend: Data curation, Visualization. Mohsen Sahebanmaleki: Conceptualization, Funding acquisition, Project administration, Resources, Supervision. Hosein Aalami: Data curation. Mitra Tavakolizadeh: Data curation, Project administration, Validation, Visualization. Sina Sabeti bilondi: Data curation, Funding acquisition, Investigation, Resources. Fatemeh Mohammadzadeh: Software, Validation, Writing – original draft. Ali Delshad Noghabi: Conceptualization, Project administration,

Declaration of Competing Interest

The manuscript is original work of author(s). All data, tables, figures, etc. used in the manuscript are prepared originally by authors, otherwise the sources are cited and reprint permission is attached.

2.

The manuscript has not been and will not be published elsewhere or submitted elsewhere for publication.

3.

Authors mention that there is no conflict of interest in this study.

4.

The paper, the final version of which I enclose, is not substantially the same as any that I/we have already published

Acknowledgements

The authors gratefully acknowledge from the Clinical Research Development Unit, Allameh Bohlool Gonabadi hospital, Gonabad University of Medical Sciences, Gonabad, Iran, and all the patients and her/his family who participated in the study.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

MS, SSB, and ADN conceived the presented idea.FM, MT, and ADN contributed to the design and concepts of the work. Data were collected by JASM, SSB, ADN, and HA. FM analyzed data and

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