Immunosuppressive microvesicles-mimetic derived from tolerant dendritic cells to target T-lymphocytes for inflammation diseases therapy

Li Z, Feng Y, Zhang S, Li T, Li H, Wang D, et al. A multifunctional nanoparticle mitigating cytokine storm by scavenging multiple inflammatory mediators of sepsis. ACS Nano. 2023;17(9):8551–63.

Article  CAS  PubMed  Google Scholar 

Ha E, Bang SY, Lim J, Yun JH, Kim JM, Bae JB, et al. Genetic variants shape rheumatoid arthritis-specific transcriptomic features in CD4(+) T cells through differential DNA methylation, explaining a substantial proportion of heritability. Ann Rheum Dis. 2021;80(7):876–83.

Article  CAS  PubMed  Google Scholar 

Suthen S, Lim CJ, Nguyen P, Dutertre CA, Lai H, Wasser M, et al. Hypoxia-driven immunosuppression by Treg and type-2 conventional dendritic cells in HCC. Hepatology. 2022;76(5):1329–44.

Article  CAS  PubMed  Google Scholar 

Lin L, Wang M, Zeng J, Mao Y, Qin R, Deng J, et al. Sequence variation of candida albicans Sap2 enhances fungal pathogenicity via complement evasion and macrophage M2-like phenotype induction. Adv Sci. 2023;10(20):e2206713.

Article  Google Scholar 

Passeri L, Andolfi G, Bassi V, Russo F, Giacomini G, Laudisa C, et al. Tolerogenic IL-10-engineered dendritic cell-based therapy to restore antigen-specific tolerance in T cell mediated diseases. J Autoimmun. 2023;138:103051.

Article  CAS  PubMed  Google Scholar 

Ohnmacht C, Pullner A, King SB, Drexler I, Meier S, Brocker T, et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity. J Exp Med. 2009;206(3):549–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gregori S, Tomasoni D, Pacciani V, Scirpoli M, Battaglia M, Magnani CF, et al. Differentiation of type 1 T regulatory cells (Tr1) by tolerogenic DC-10 requires the IL-10-dependent ilt4/hla-g pathway. Blood. 2010;116(6):935–44.

Article  CAS  PubMed  Google Scholar 

Chu CC, Ali N, Karagiannis P, Di Meglio P, Skowera A, Napolitano L, et al. Resident CD141 (bdca3) + dendritic cells in human skin produce IL-10 and induce regulatory T cells that suppress skin inflammation. J Exp Med. 2012;209(5):935–45.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Colonna M, Navarro F, Bellon T, Llano M, Garcia P, Samaridis J, et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. 1997;186(11):1809–18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fanger NA, Maliszewski CR, Schooley K, Griffith TS. Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (trail). J Exp Med. 1999;190(8):1155–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Min Z, Zeng Y, Zhu T, Cui B, Mao R, Jin M, et al. Lipopolysaccharide-activated bone marrow-derived dendritic cells suppress allergic airway inflammation by ameliorating the immune microenvironment. Front Immunol. 2021;12:595369.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Hou C, Yang N, Yang Y, Chen Y, Kong D, et al. Regulatory effect of jak2/stat3 on the immune function of endotoxin-tolerant dendritic cells and its involvement in acute liver failure. J Clin Transl Hepatol. 2022;10(5):879–90.

Article  PubMed  PubMed Central  Google Scholar 

Giannoukakis N, Phillips B, Finegold D, Harnaha J, Trucco M. Phase I (safety) study of autologous tolerogenic dendritic cells in type 1 diabetic patients. Diabetes Care. 2011;34(9):2026–32.

Article  PubMed  PubMed Central  Google Scholar 

Benham H, Nel HJ, Law SC, Mehdi AM, Street S, Ramnoruth N, et al. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients. Sci Transl Med. 2015;7(290):r287–90.

Article  Google Scholar 

Bell GM, Anderson AE, Diboll J, Reece R, Eltherington O, Harry RA, et al. Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis. Ann Rheum Dis. 2017;76(1):227–34.

Article  CAS  PubMed  Google Scholar 

Zubizarreta I, Florez-Grau G, Vila G, Cabezon R, Espana C, Andorra M, et al. Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial. Proc Natl Acad Sci USA. 2019;116(17):8463–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blazar BR, MacDonald K, Hill GR. Immune regulatory cell infusion for graft-versus-host disease prevention and therapy. Blood. 2018;131(24):2651–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu R, Greening DW, Zhu HJ, Takahashi N, Simpson RJ. Extracellular vesicle isolation and characterization: toward clinical application. J Clin Invest. 2016;126(4):1152–62.

Article  PubMed  PubMed Central  Google Scholar 

van Niel G, D’Angelo G, Raposo G. Shedding light on the cell biology of extracellular vesicles. Nat Rev Mol Cell Biol. 2018;19(4):213–28.

Article  PubMed  Google Scholar 

Tang TT, Wang B, Lv LL, Liu BC. Extracellular vesicle-based nanotherapeutics: emerging frontiers in anti-inflammatory therapy. Theranostics. 2020;10(18):8111–29.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jang SC, Kim OY, Yoon CM, Choi DS, Roh TY, Park J, et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors. ACS Nano. 2013;7(9):7698–710.

Article  CAS  PubMed  Google Scholar 

Lee JR, Park BW, Kim J, Choo YW, Kim HY, Yoon JK, et al. Nanovesicles derived from iron oxide nanoparticles-incorporated mesenchymal stem cells for cardiac repair. Sci Adv. 2020;6(18):z952.

Article  Google Scholar 

Zhang G, Huang X, Xiu H, Sun Y, Chen J, Cheng G, et al. Extracellular vesicles: natural liver-accumulating drug delivery vehicles for the treatment of liver diseases. J Extracell Vesicles. 2020;10(2):e12030.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Zhuang X, Greene KS, Si H, Antonyak MA, Druso JE, et al. Cdc42 functions as a regulatory node for tumour-derived microvesicle biogenesis. J Extracell Vesicles. 2021;10(3):e12051.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Antonyak MA, Li B, Boroughs LK, Johnson JL, Druso JE, Bryant KL, et al. Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc Natl Acad Sci USA. 2011;108(12):4852–57.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng Q, Zhang C, Lum D, Druso JE, Blank B, Wilson KF, et al. A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. Nat Commun. 2017;8:14450.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan J, Lee CS, Kim S, Chen C, Aghaloo T, Lee M. Generation of small RNA-modulated exosome mimetics for bone regeneration. ACS Nano. 2020;14(9):11973–84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu F, Fei Z, Dai H, Xu J, Fan Q, Shen S, et al. Mesenchymal stem cell-derived extracellular vesicles with high PD-L1 expression for autoimmune diseases treatment. Adv Mater. 2022;34(1):e2106265.

Article  PubMed  Google Scholar 

Tsai HI, Wu Y, Liu X, Xu Z, Liu L, Wang C, et al. Engineered small extracellular vesicles as a fgl1/PD-L1 dual-targeting delivery system for alleviating immune rejection. Adv Sci. 2022;9(3):e2102634.

Article  Google Scholar 

Riazifar M, Mohammadi MR, Pone EJ, Yeri A, Lasser C, Segaliny AI, et al. Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders. ACS Nano. 2019;13(6):6670–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Efimova I, Catanzaro E, Van der Meeren L, Turubanova VD, Hammad H, Mishchenko TA et al. Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity. J Immunother Cancer. 2020;8(2).

Manni G, Mondanelli G, Scalisi G, Pallotta MT, Nardi D, Padiglioni E, et al. Pharmacologic induction of endotoxin tolerance in dendritic cells by L-kynurenine. Front Immunol. 2020;11:292.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan Z, Zhu P, Zhu Y, Wu K, Li CY, Cheng H. Engineering long-circulating nanomaterial delivery systems. Curr Opin Biotechnol. 2020;66:131–9.

Article  CAS  PubMed  Google Scholar 

Xiao P, Wang J, Zhao Z, Liu X, Sun X, Wang D, et al. Engineering nanoscale artificial antigen-presenting cells by metabolic dendritic cell labeling to potentiate cancer immunotherapy. Nano Lett. 2021;21(5):2094–103.

Article  CAS  PubMed  Google Scholar 

Ruan S, Erwin N, He M. Light-induced high-efficient cellular production of immune functional extracellular vesicles. J Extracell Vesicles. 2022;11(3):e12194.

Article  CAS  PubMed  PubMed Central 

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