Mitochondrial-dependent oxidative phosphorylation is key for postnatal metabolic adaptation of alveolar macrophages in the lung

Keywords

Alveolar macrophages

mitochondrial transcription factor A

Metabolic adaptation

Endoplasmic reticulum stress

AbbreviationsTFAM

mitochondrial transcription factor A

qRT-PCR

quantitative real time −polymerase chain reaction

OXPHOS

oxidative phosphorylation

BOK

B cell lymphoma 2 ovarian killer

pMacs

primitive macrophages

GM-CSF

granulocyte macrophage colony stimulating factor

TGF-β

transforming growth factor-β

TCA

tricarboxylic acid cycle

ETC

electron transport chain

HSC

hematopoietic stem cell

OCR

oxygen consumption rate

ECAR

extracellular acidification rate

MFI

mean fluorescence intensity

PAP

pulmonary alveolar proteinosis

FCCP

fluorocarbonyl cyanide phenylhydrazone

PCA

principal component analysis

DEGs

differentially expressed genes

GSEA

gene set enrichment analysis

mPTP

mitochondrial permeability transition pore

SERCA

sarco/endoplasmic reticulum Ca2+-ATPase

4-PBA

4-phenylbutyric acid

Data availability

Data will be made available on request.

© 2024 The Author(s). Published by Elsevier B.V.

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