Wachtel, E. V., Verma, S. & Mally, P. V. Update on the current management of newborns with neonatal encephalopathy. Curr. Probl. Pediatr. Adolesc. Health Care 49, 100636 (2019).
Northington, F. J. et al. Failure to complete apoptosis following neonatal hypoxia-ischemia manifests as “continuum” phenotype of cell death and occurs with multiple manifestations of mitochondrial dysfunction in rodent forebrain. Neuroscience 149, 822–833 (2007).
Article CAS PubMed Google Scholar
Wassink, G., Gunn, E. R., Drury, P. P., Bennet, L. & Gunn, A. J. The mechanisms and treatment of asphyxial encephalopathy. Front. Neurosci. 8, 40 (2014).
Article PubMed PubMed Central Google Scholar
Edwards, A. D. et al. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial data. BMJ 340, c363 (2010).
Article PubMed PubMed Central Google Scholar
Perlman, J. M., Davis, P., Wyllie, J. & Kattwinkel, J. Therapeutic hypothermia following intrapartum hypoxia-ischemia. An advisory statement from the neonatal task force of the international liaison committee on resuscitation. Resuscitation 81, 1459–1461 (2010).
Shankaran, S. Therapeutic hypothermia for neonatal encephalopathy. Curr. Treat. Options Neurol. 14, 608–619 (2012).
Article PubMed PubMed Central Google Scholar
Committee on Fetus and Newborn; Papile, L.A. et al. Hypothermia and neonatal encephalopathy. Pediatrics 133, 1146–1150 (2014).
Beltempo, M. et al. Variations in practices and outcomes of neonates with hypoxic ischemic encephalopathy treated with therapeutic hypothermia across tertiary NICUs in Canada. J. Perinatol. 42, 898–906 (2022).
Article CAS PubMed Google Scholar
Adams, M. et al. Process variations between Swiss units treating neonates with hypoxic-ischemic encephalopathy and their effect on short-term outcome. J. Perinatol. 41, 2804–2812 (2021).
Article PubMed PubMed Central Google Scholar
Walsh, B. H. et al. Comparison of numerical and standard sarnat grading using the NICHD and SIBEN methods. J. Perinatol. 42, 328–334 (2022).
Walsh, B. H. et al. Differences in standardized neonatal encephalopathy exam criteria may impact therapeutic hypothermia eligibility. Pediatr. Res. 92, 791–798 (2022).
Shankaran, S. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 353, 1574–1584 (2005).
Article CAS PubMed Google Scholar
Chalak, L. F., Adams-Huet, B. & Sant’Anna, G. A total sarnat score in mild hypoxic-ischemic encephalopathy can detect infants at higher risk of disability. J. Pediatr. 214, 217–221.e1 (2019).
Lemyre, B. & Chau, V. Hypothermia for newborns with hypoxic-ischemic encephalopathy. Paediatr. Child Health 23, 285–291 (2018).
Article PubMed PubMed Central Google Scholar
Perez, J. M., Golombek, S. G. & Sola, A. Clinical hypoxic-ischemic encephalopathy score of the Iberoamerican Society of Neonatology (Siben): a new proposal for diagnosis and management. Rev. Assoc. Med. Bras. 63, 64–69 (2017).
Groenendaal, F. & Brouwer, M. Landelijke aanbeveling: Therapeutische hypothermie na perinatale asfyxie [Internet]. 2014 [cited 2023 Dec 31]. Available from: https://neonatology.eu/sites/neonatology.eu/files/hypothermie.pdf.
British Association of Perinatal Medicine (BAPM). Therapeutic Hypothermia for Neonatal Encephalopathy, a framework for practice. Available at (accessed 09 August 2023): https://www.bapm.org/resources/237-therapeutic-hypothermia-for-neonatal-encephalopathy.
San Lazaro Campillo I. et al. on behalf of Neonatal Therapeutic Hypothermia Steering Group. Neonatal Therapeutic Hypothermia in Ireland, Annual Report 2016-2020. Available at: https://www.hse.ie/eng/about/who/acute-hospitals-division/woman-infants/national-reports-on-womens-health/neonatal-therapeutic-hypothermia-in-ireland-annual-report-2020.pdf.
Takenouchi, T., Iwata, O., Nabetani, M. & Tamura, M. Therapeutic hypothermia for neonatal encephalopathy: JSPNM & MHLW Japan Working Group Practice Guidelines Consensus Statement from the Working Group on Therapeutic Hypothermia for Neonatal Encephalopathy, Ministry of Health, Labor and Welfare (MHLW), Japan, and Japan Society for Perinatal and Neonatal Medicine (JSPNM). Brain Dev. 34, 165–170 (2012).
Queensland Clinical Guidelines. Hypoxic ischaemic encephalopathy (HIE). Guideline No. MN21.11-V11-R26. Queensland Health. 2021 Available from: http://www.health.qld.gov.au/qcg.
Hypoxic Ischaemic Encephalopathy in the Newborn. Sydney Children’s Hospitals Network, Newborn and Paediatric Emergency Transport Service (NETS). Date of Publishing: 15 March 2022. accessed 21 September 2023.
Neonatal Encephalopathy Consensus Statement from the Newborn Clinical Network. New Zealand Child and Youth Clinical Networks (NZCYCN). Date last published: 30 October 2019. Available from: Neonatal Encephalopathy Consensus Statement from the Newborn Clinical Network (starship.org.nz).
Eicher, D. J. et al. Moderate hypothermia in neonatal encephalopathy: safety outcomes. Pediatr. Neurol. 32, 18–24 (2005).
Jacobs, S. E. et al. Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial. Arch. Pediatr. Adolesc. Med. 165, 692–700 (2011).
Kim S. H., El-Shibiny H., Inder T., El-Dib M. Therapeutic hypothermia for preterm infants 34-35 weeks gestational age with neonatal encephalopathy. J. Perinatol. https://doi.org/10.1038/s41372-024-01874-x (2024).
Moran P., Sullivan K., Zanelli S. A., Burnsed J. Single-center Experience with Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy in Infants with <36 Weeks’ Gestation. Am. J. Perinatol. https://doi.org/10.1055/a-2251-6317 (2024).
Faix R. et al. The Preemie Hypothermia Sub-Committee of the Neonatal Research. Randomized Trial of Targeted Temperature Management with Whole Body Hypothermia for Moderate and Severe Encephalopathy in Premature Infants 33-35 Weeks Gestation – A Bayesian Study (aka Preemie Hypothermia). Pediatric Academic Societies Annual Meeting, Washington, April 27-May 1 2023. Available at (accessed 09 August 2023): https://neonatal.rti.org/index.cfm?fuseaction=Publications_Public.ff&f=PAS_2023_Abstracts/PAS_2023_Preemie_Hypo.pdf.
Azzopardi, D. et al. Effects of hypothermia for perinatal asphyxia on childhood outcomes. N. Engl. J. Med. 371, 140–149 (2014).
Article CAS PubMed Google Scholar
Gunn, A. J., Bennet, L., Gunning, M. I., Gluckman, P. D. & Gunn, T. R. Cerebral hypothermia is not neuroprotective when started after postischemic seizures in fetal sheep. Pediatr. Res. 46, 274–280 (1999).
Article CAS PubMed Google Scholar
Laptook, A. R. et al. Effect of therapeutic hypothermia initiated after 6 h of age on death or disability among newborns with hypoxic-ischemic encephalopathy: a randomized clinical trial. JAMA 318, 1550–1560 (2017).
Article PubMed PubMed Central Google Scholar
Jacobs, S. E. et al. Cooling for newborns with hypoxic ischaemic encephalopathy. Cochrane Database Syst. Rev. 2013, CD003311 (2013).
PubMed PubMed Central Google Scholar
Sarnat, H. B. & Sarnat, M. S. Neonatal encephalopathy following fetal distress. A clinical and electroencephalographic study. Arch. Neurol. 33, 696–705 (1976).
Article CAS PubMed Google Scholar
Simbruner, G., Mittal, R. A., Rohlmann, F. & Muche, R., neo.nEURO.network Trial Participants. Systemic hypothermia after neonatal encephalopathy: outcomes of neo.nEURO.network RCT. Pediatrics 126, e771–e778 (2010).
Thompson, C. M. et al. The value of a scoring system for hypoxic ischaemic encephalopathy in predicting neurodevelopmental outcome. Acta Paediatr. 86, 757–761 (1997).
Article CAS PubMed Google Scholar
Sarnat, H. B. et al. Sarnat grading scale for neonatal encephalopathy after 45 Years: an update proposal. Pediatr. Neurol. 113, 75–79 (2020).
Gunn, A. J., Gunn, T. R., Gunning, M. I., Williams, C. E. & Gluckman, P. D. Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep. Pediatrics 102, 1098–1106 (1998).
Article CAS PubMed Google Scholar
Azzopardi, D. V. et al. Moderate hypothermia to treat perinatal asphyxial encephalopathy. N. Engl. J. Med. 361, 1349–1358 (2009).
Article CAS PubMed Google Scholar
Thoresen, M. et al. Time is brain: starting therapeutic hypothermia within three hours after birth improves motor outcome in asphyxiated newborns. Neonatology 104, 228–233 (2013).
White, Y. N., Grant, P. E., Soul, J. S., Inder, T. & El-Dib, M. Early exit from neonatal therapeutic hypothermia: a single institution experience using MRI to guide decision-making. J. Neonatal Perinat. Med. 13, 441–447 (2020).
Malone, A. et al. Interobserver agreement in neonatal seizure identification. Epilepsia 50, 2097–2101 (2009).
Pellegrin, S. et al. Neonatal seizures: case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 37, 7596–7609 (2019).
Article PubMed PubMed Central Google Scholar
Lynch, N. E. et al. The temporal characteristics of seizures in neonatal hypoxic ischemic encephalopathy treated with hypothermia. Seizure 33, 60–65 (2015).
Davies, A., Wassink, G., Bennet, L., Gunn, A. J. & Davidson, J. O. Can we further optimize therapeutic hypothermia for hypoxic-ischemic encephalopathy? Neural Regen. Res. 14, 1678–1683 (2019).
Article PubMed PubMed Central Google Scholar
Low, E. et al. Cooling and seizure burden in term neonates: an observational study. Arch. Dis. Child Fetal Neonatal Ed. 97, F267–F272 (2012).
Wyatt, J. S. et al. Determinants of outcomes after head cooling for neonatal encephalopathy. Pediatrics 119, 912–921 (2007).
留言 (0)