Piaggi P, Vinales KL, Basolo A, Santini F, Krakoff J. Energy expenditure in the etiology of human obesity: spendthrift and thrifty metabolic phenotypes and energy-sensing mechanisms. J Endocrinol Invest. 2018;41:83–9.
Article CAS PubMed Google Scholar
Haslam DW, James WPT. Obesity. Lancet. 2005;366:1197–209.
Yoneshiro T, Aita S, Matsushita M, Kameya T, Nakada K, Kawai Y, et al. Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men. Obesity. 2011;19:13–16.
Saito M, Okamatsu-Ogura Y, Matsushita M, Watanabe K, Yoneshiro T, Nio-Kobayashi J, et al. High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity. Diabetes. 2009;58:1526–31.
Article CAS PubMed PubMed Central Google Scholar
Yoneshiro T, Aita S, Matsushita M, Okamatsu-Ogura Y, Kameya T, Kawai Y, et al. Age-related decrease in cold-activated brown adipose tissue and accumulation of body fat in healthy humans. Obesity. 2011;19:1755–60.
Chernogubova E, Cannon B, Bengtsson T. Norepinephrine increases glucose transport in brown adipocytes via beta3-adrenoceptors through a cAMP, PKA, and PI3-kinase-dependent pathway stimulating conventional and novel PKCs. Endocrinology. 2004;145:269–80.
Article CAS PubMed Google Scholar
Zhao J, Unelius L, Bengtsson T, Cannon B, Nedergaard J. Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells. Am J Physiol. 1994;267:C969–79.
Article CAS PubMed Google Scholar
Warner A, Kjellstedt A, Carreras A, Böttcher G, Peng XR, Seale P, et al. Activation of β3-adrenoceptors increases in vivo free fatty acid uptake and utilization in brown but not white fat depots in high-fat-fed rats. Am J Physiol Endocrinol Metab. 2016;311:E901–10.
Article PubMed PubMed Central Google Scholar
Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS ONE. 2012;7:e49452.
Article CAS PubMed PubMed Central Google Scholar
Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, et al. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med. 2013;19:635–9.
Article CAS PubMed PubMed Central Google Scholar
Langin D, Tavernier G, Lafontan M. Regulation of beta 3-adrenoceptor expression in white fat cells. Fundam Clin Pharm. 1995;9:97–106.
Blondin DP, Nielsen S, Kuipers EN, Severinsen MC, Jensen VH, Miard S, et al. Human brown adipocyte thermogenesis is driven by β2-AR stimulation. Cell Metab. 2020;32:287–300.e7.
Article CAS PubMed Google Scholar
Cypess AM, Weiner LS, Roberts-Toler C, Franquet Elía E, Kessler SH, Kahn PA, et al. Activation of human brown adipose tissue by a β3-adrenergic receptor agonist. Cell Metab. 2015;21:33–8.
Article CAS PubMed PubMed Central Google Scholar
O’Mara AE, Johnson JW, Linderman JD, Brychta RJ, McGehee S, Fletcher LA, et al. Chronic mirabegron treatment increases human brown fat, HDL cholesterol, and insulin sensitivity. J Clin Invest. 2020;130:2209–19.
Article PubMed PubMed Central Google Scholar
Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng YH, Cypess AM. β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis. JCI Insight. 2021;6:e139160.
Article PubMed PubMed Central Google Scholar
Riis-Vestergaard MJ, Richelsen B, Bruun JM, Li W, Hansen JB, Pedersen SB. Beta-1 and not beta-3 adrenergic receptors may be the primary regulator of human brown adipocyte metabolism. J Clin Endocrinol Metab. 2020;105:e994–1005.
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, et al. Identification and importance of brown adipose tissue in adult humans. N Engl J Med. 2009;360:1509–17.
Article CAS PubMed PubMed Central Google Scholar
van Marken Lichtenbelt WD, Vanhommerig JW, Smulders NM, Drossaerts JM, Kemerink GJ, Bouvy ND, et al. Cold-activated brown adipose tissue in healthy men. N Engl J Med. 2009;360:1500–8.
Virtanen KA, Lidell ME, Orava J, Heglind M, Westergren R, Niemi T, et al. Functional brown adipose tissue in healthy adults. N Engl J Med. 2009;360:1518–25.
Article CAS PubMed Google Scholar
Yoneshiro T, Ogawa T, Okamoto N, Matsushita M, Aita S, Kameya T, et al. Impact of UCP1 and beta3AR gene polymorphisms on age-related changes in brown adipose tissue and adiposity in humans. Int J Obes. 2013;37:993–8.
Nakayama K, Miyashita H, Yanagisawa Y, Iwamoto S. Seasonal effects of UCP1 gene polymorphism on visceral fat accumulation in Japanese adults. PLoS ONE. 2013;8:e74720.
Article CAS PubMed PubMed Central Google Scholar
Park HS, Shin ES, Lee JE. Genotypes and haplotypes of beta2-adrenergic receptor and parameters of the metabolic syndrome in Korean adolescents. Metabolism. 2008;57:1064–70.
Article CAS PubMed Google Scholar
Gjesing AP, Sparsø T, Borch-Johnsen K, Jørgensen T, Pedersen O, Hansen T, et al. No consistent effect of ADRB2 haplotypes on obesity, hypertension and quantitative traits of body fatness and blood pressure among 6,514 adult Danes. PLoS ONE. 2009;4:e7206.
Article PubMed PubMed Central Google Scholar
Prior SJ, Goldberg AP, Ryan AS. ADRB2 haplotype is associated with glucose tolerance and insulin sensitivity in obese postmenopausal women. Obesity. 2011;19:396–401.
Article CAS PubMed Google Scholar
Pfannenberg C, Werner MK, Ripkens S, Stef I, Deckert A, Schmadl M, et al. Impact of age on the relationships of brown adipose tissue with sex and adiposity in humans. Diabetes. 2010;59:1789–93.
Article CAS PubMed PubMed Central Google Scholar
Yoneshiro T, Matsushita M, Nakae S, Kameya T, Sugie H, Tanaka S, et al. Brown adipose tissue is involved in the seasonal variation of cold-induced thermogenesis in humans. Am J Physiol Regul Integr Comp Physiol. 2016;310:R999–1009.
Matsushita M, Nirengi S, Hibi M, Wakabayashi H, Lee S-I, Domichi M, et al. Diurnal variations of brown fat thermogenesis and fat oxidation in humans. Int J Obes. 2021;45:2499–505.
Nirengi S, Yoneshiro T, Sugie H, Saito M, Hamaoka T. Human brown adipose tissue assessed by simple, noninvasive near-infrared time-resolved spectroscopy. Obesity. 2015;23:973–80.
Article CAS PubMed Google Scholar
Fuse S, Nirengi S, Amagasa S, Homma T, Kime R, Endo T, et al. Brown adipose tissue density measured by near-infrared time-resolved spectroscopy in Japanese, across a wide age range. J Biomed Opt. 2018;23:1–9.
Nirengi S, Wakabayashi H, Matsushita M, Domichi M, Suzuki S, Sukino S, et al. An optimal condition for the evaluation of human brown adipose tissue by infrared thermography. PLoS ONE. 2019;14:e0220574.
Article CAS PubMed PubMed Central Google Scholar
1000 Genomes Project Consortium. A global reference for human genetic variation. Nature. 2015;526:68–74.
Pereira TV, Mingroni-Netto RC, Yamada Y. ADRB2 and LEPR gene polymorphisms: synergistic effects on the risk of obesity in Japanese. Obesity. 2011;19:1523–7.
Article CAS PubMed Google Scholar
Nakayama K, Inaba Y. Genetic variants influencing obesity-related traits in Japanese population. Ann Hum Biol. 2019;46:298–304.
Zhao S, Zhang W, Nie X. Association of β2-adrenergic receptor gene polymorphisms (rs1042713, rs1042714, rs1042711) with asthma risk: a systematic review and updated meta-analysis. BMC Pulm Med. 2019;19:202.
Article PubMed PubMed Central Google Scholar
Ahles A, Engelhardt S. Polymorphic variants of adrenoceptors: pharmacology, physiology, and role in disease. Pharm Rev. 2014;66:598–637.
Ward LD, Kellis M. HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants. Nucleic Acids Res. 2011;40:D930–4.
Article PubMed PubMed Central Google Scholar
Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D, Mann AL, et al. The allelic landscape of human blood cell trait variation and links to common complex disease. Cell. 2016;167:1415–29.e19.
留言 (0)