Liu L, Shi Z, Ji X, Zhang W, Luan J, Zahr T, et al. Adipokines, adiposity, and atherosclerosis. Cell Mol Life Sci. 2022;79(5):272. https://doi.org/10.1007/s00018-022-04286-2.

Article  CAS  PubMed  Google Scholar 

Bentzon JF, Otsuka F, Virmani R, Falk E. Mechanisms of plaque formation and rupture. Circ Res. 2014;114(12):1852–66. https://doi.org/10.1161/circresaha.114.302721.

Article  CAS  PubMed  Google Scholar 

Montarello NJ, Nguyen MT, Wong DTL, Nicholls SJ, Psaltis PJ. Inflammation in coronary atherosclerosis and its therapeutic implications. Cardiovasc Drugs Ther. 2022;36(2):347–62. https://doi.org/10.1007/s10557-020-07106-6.

Article  CAS  PubMed  Google Scholar 

Bai Y, Sun Q. Macrophage recruitment in obese adipose tissue. Obes Rev. 2015;16(2):127–36. https://doi.org/10.1111/obr.12242.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Maddux BA, See W, Lawrence JC Jr., Goldfine AL, Goldfine ID, Evans JL. Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid. Diabetes. 2001;50(2):404–10. https://doi.org/10.2337/diabetes.50.2.404.

Article  CAS  PubMed  Google Scholar 

Ceriello A, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. 2004;24(5):816–23. https://doi.org/10.1161/01.Atv.0000122852.22604.78.

Article  CAS  PubMed  Google Scholar 

Zhou Y, Wei Y, Wang L, Wang X, Du X, Sun Z, et al. Decreased adiponectin and increased inflammation expression in epicardial adipose tissue in coronary artery disease. Cardiovasc Diabetol. 2011;10:2. https://doi.org/10.1186/1475-2840-10-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kawano J, Arora R. The role of adiponectin in obesity, diabetes, and cardiovascular disease. J Cardiometab Syndr. 2009;4(1):44–9. https://doi.org/10.1111/j.1559-4572.2008.00030.x.

Article  PubMed  Google Scholar 

Zaidi H, Byrkjeland R, Njerve IU, Åkra S, Solheim S, Arnesen H, et al. Adiponectin in relation to exercise and physical performance in patients with type 2 diabetes and coronary artery disease. Adipocyte. 2021;10(1):612–20. https://doi.org/10.1080/21623945.2021.1996699.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fadaei R, Moradi N, Kazemi T, Chamani E, Azdaki N, Moezibady SA, et al. Decreased serum levels of CTRP12/adipolin in patients with coronary artery disease in relation to inflammatory cytokines and insulin resistance. Cytokine. 2019;113:326–31. https://doi.org/10.1016/j.cyto.2018.09.019.

Article  CAS  PubMed  Google Scholar 

Schäffler A, Buechler C. CTRP family: linking immunity to metabolism. Trends Endocrinol Metab. 2012;23(4):194–204. https://doi.org/10.1016/j.tem.2011.12.003.

Article  CAS  PubMed  Google Scholar 

Lei X, Seldin MM, Little HC, Choy N, Klonisch T, Wong GW. C1q/TNF-related protein 6 (CTRP6) links obesity to adipose tissue inflammation and insulin resistance. J Biol Chem. 2017;292(36):14836–50. https://doi.org/10.1074/jbc.M116.766808.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang M, Tang X, Li L, Liu D, Liu H, Zheng H, et al. C1q/TNF-related protein-6 is associated with insulin resistance and the development of diabetes in Chinese population. Acta Diabetol. 2018;55(12):1221–9. https://doi.org/10.1007/s00592-018-1203-2.

Article  CAS  PubMed  Google Scholar 

Zheng WF, Zhang SY, Ma HF, Chang XW, Wang H. C1qTNF-related protein-6 protects against doxorubicin-induced cardiac injury. J Cell Biochem. 2019;120(6):10748–55. https://doi.org/10.1002/jcb.28366.

Article  CAS  PubMed  Google Scholar 

Murayama MA, Kakuta S, Inoue A, Umeda N, Yonezawa T, Maruhashi T, et al. CTRP6 is an endogenous complement regulator that can effectively treat induced arthritis. Nat Commun. 2015;6(1):1–12.

Article  Google Scholar 

Kim MJ, Lee W, Park EJ, Park SY. C1qTNF-related protein-6 increases the expression of interleukin-10 in macrophages. Mol Cells. 2010;30(1):59–64. https://doi.org/10.1007/s10059-010-0088-x.

Article  CAS  PubMed  Google Scholar 

Lei H, Wu D, Wang J-Y, Li L, Zhang C-L, Feng H, et al. C1q/tumor necrosis factor-related protein-6 attenuates post-infarct cardiac fibrosis by targeting RhoA/MRTF-A pathway and inhibiting myofibroblast differentiation. Basic Res Cardiol. 2015;110(4):35. https://doi.org/10.1007/s00395-015-0492-7.

Article  CAS  PubMed  Google Scholar 

Wei C, Liu Y, Xing E, Ding Z, Tian Y, Zhao Z, et al. Association between Novel Pro- and Anti- Inflammatory adipocytokines in patients with Acute Coronary Syndrome. Clin Appl Thromb Hemost. 2022;28:10760296221128021. https://doi.org/10.1177/10760296221128021.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Emamgholipour S, Moradi N, Beigy M, Shabani P, Fadaei R, Poustchi H, et al. The association of circulating levels of complement-C1q TNF-related protein 5 (CTRP5) with nonalcoholic fatty liver disease and type 2 diabetes: a case-control study. Diabetol Metab Syndr. 2015;7:108. https://doi.org/10.1186/s13098-015-0099-z.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fadaei R, Moradi N, Baratchian M, Aghajani H, Malek M, Fazaeli AA, et al. Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 serum levels with coronary artery disease in subjects with and without type 2 diabetes Mellitus. PLoS ONE. 2016;11(12):e0168773. https://doi.org/10.1371/journal.pone.0168773.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bai B, Ban B, Liu Z, Zhang MM, Tan BK, Chen J. Circulating C1q complement/TNF-related protein (CTRP) 1, CTRP9, CTRP12 and CTRP13 concentrations in type 2 diabetes mellitus: in vivo regulation by glucose. PLoS ONE. 2017;12(2):e0172271.

Article  PubMed  PubMed Central  Google Scholar 

Seldin MM, Tan SY, Wong GW. Metabolic function of the CTRP family of hormones. Reviews Endocr Metabolic Disorders. 2014;15(2):111–23. https://doi.org/10.1007/s11154-013-9255-7.

Article  CAS  Google Scholar 

Lu L, Zhang RY, Wang XQ, Liu ZH, Shen Y, Ding FH, et al. C1q/TNF-related protein-1: an adipokine marking and promoting atherosclerosis. Eur Heart J. 2016;37(22):1762–71.

Article  PubMed  Google Scholar 

Moradi N, Fadaei R, Emamgholipour S, Kazemian E, Panahi G, Vahedi S, et al. Association of circulating CTRP9 with soluble adhesion molecules and inflammatory markers in patients with type 2 diabetes mellitus and coronary artery disease. PLoS ONE. 2018;13(1):e0192159.

Article  PubMed  PubMed Central  Google Scholar 

Wong GW, Krawczyk SA, Kitidis-Mitrokostas C, Revett T, Gimeno R, Lodish HF. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. Biochem J. 2008;416(2):161–77. https://doi.org/10.1042/bj20081240.

Article  CAS  PubMed  Google Scholar 

Xu E, Yin C, Yi X, Liu Y. Knockdown of CTRP6 inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells through regulating the Akt/NF‐κB pathway. Clin Exp Pharmacol Physiol. 2020;47(7):1203–11.

Article  CAS  PubMed  Google Scholar 

Lee W, Kim MJ, Park EJ, Choi YJ, Park SY. C1qTNF-related protein-6 mediates fatty acid oxidation via the activation of the AMP-activated protein kinase. FEBS Lett. 2010;584(5):968–72. https://doi.org/10.1016/j.febslet.2010.01.040.

Article  CAS  PubMed  Google Scholar 

Sadeghi A, Fadaei R, Moradi N, Fouani FZ, Roozbehkia M, Zandieh Z et al. Circulating levels of C1q/TNF-α-related protein 6 (CTRP6) in polycystic ovary syndrome. 2020;72(7):1449–59; https://doi.org/10.1002/iub.2272.

Liao X, Liu S, Tang X, Yang D, Liu H, Gao L, et al. Circulating CTRP6 levels are increased in overweight or obese Chinese individuals and Associated with insulin resistance parameters: a pilot study. Experimental and clinical endocrinology & diabetes: official journal. German Soc Endocrinol [and] German Diabetes Association. 2021;129(7):535–41. https://doi.org/10.1055/a-0929-6072.

Article  CAS  Google Scholar 

Wu WJ, Mo DL, Zhao CZ, Zhao C, Chen YS, Pang WJ, et al. Knockdown of CTRP6 inhibits adipogenesis via lipogenic marker genes and Erk1/2 signalling pathway. Cell Biol Int. 2015;39(5):554–62. https://doi.org/10.1002/cbin.10422.

Article  CAS  PubMed  Google Scholar 

Wu W, Sun Y, Zhao C, Zhao C, Chen X, Wang G, et al. Lipogenesis in myoblasts and its regulation of CTRP6 by AdipoR1/Erk/PPARγ signaling pathway. Acta Biochim Biophys Sin. 2016;48(6):509–19.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Y, Sun J, Gu L, Gao X. Protective effect of CTRP6 on cerebral ischemia/reperfusion injury by attenuating inflammation, oxidative stress and apoptosis in PC12 cells. Mol Med Rep. 2020;22(1):344–52. https://doi.org/10.3892/mmr.2020.11108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu E, Yin C, Yi X, Liu Y. Knockdown of CTRP6 inhibits high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation in mesangial cells through regulating the Akt/NF-κB pathway. Clin Exp Pharmacol Physiol. 2020;47(7):1203–11. https://doi.org/10.1111/1440-1681.13289.