*Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China

†Department of Pathology, Eye and ENT Hospital, Fudan University, Shanghai, China

‡Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, China

C.H. and Y.L. contributed equally to this work.

The current study was approved by the Ethics Committee of the Eye & ENT Hospital of Fudan University and performed in strict accordance with the Declaration of Helsinki. All participants in this study signed informed consent documentation.

C.H. and Y.L.: Conceived and designed the experiments; performed the experiments; analyzed and interpreted the data; contributed reagents, materials, analysis tools, or data; wrote the paper. C.H., Y.L., and L.L.: Performed the experiments; analyzed and interpreted the data; and wrote the paper. C.Y., D.M., and Q.H.: Conceived and designed the experiments; reviewed the paper.

Data will be made available on request.

The present study was supported by grants from the Shanghai Sailing Program (No. 23YF1404700) and the Natural Science Foundation of Minhang District, Shanghai (2023MHZ070).

Conflicts of Interest and Source of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article.

Correspondence: Qiang Huang, MD, Department of Otorhinolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, China (e-mail: [email protected]). Duan Ma, PhD, Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China (e-mail: [email protected]), and Cuncun Yuan, MM, Department of Pathology, Eye and ENT Hospital, Fudan University, Shanghai, China (e-mail: [email protected]).