The Curing Coma Campaign (CCC) and its contributing collaborators identified multiple key areas of knowledge and research gaps in coma and disorders of consciousness (DoC). This step was a crucial effort and essential to prioritize future educational and research efforts. These key areas include defining categories of DoC, assessing DoC using multimodal approach (e.g., behavioral assessment tools, advanced neuroimaging studies), discussing optimal clinical trials' design and exploring computational models to conduct clinical trials in patients with DoC, and establishing common data elements to standardize data collection. Other key areas focused on creating coma care registry and educating clinicians and patients and promoting awareness of DoC to improve care in patients with DoC. The ongoing efforts in these key areas are discussed.

K.K. drafted initial manuscript, provided substantial intellectual contribution, integrated feedback from co-authors, and brought the document to its final form. L.P., J.S., D.O. and C.H. contributed in critical review of the manuscript and provided essential intellectual content.

S.M. Drafted and revised portions of the manuscript, substantial intellectual insights on the overall manuscript, critical review and finalization of the manuscript.

Article published online:
17 April 2024

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