An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers an efficient and convenient approach for the rapid assembly of a variety of β-lactams and pyrazolidinones scaffolds with structural and functional importance. Moreover, continuous flow chemistry has also been employed for two photochemical processes and gram-scale synthesis (up to 100 times) with comparable efficiency to the batch conditions in relatively shorten time, which allowed high throughout synthesis and exhibited an increase in productivity.

You have access to this article

Please wait while we load your content... Something went wrong. Try again?